Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.

Abstract:

:Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 receptors (H3R) in a series of major cortical and basal ganglia structures in human DLB and Alzheimer's (AD) post-mortem cases using the highly selective radioligand, [3H] GSK189254. In the main, the levels of H3 receptor were largely preserved in DLB cases when compared with aged-matched controls. However, we provide new evidence showing variable levels in the globus pallidus, and, moreover, raised levels of Pallidum H3 correlated with positive psychotic symptoms, in particular delusions and visual hallucinations, but not symptoms associated with depression. Furthermore, no correlation was detected for H3 receptor levels to MMSE or IUPRS symptom severity. This study suggests that H3R antagonists have scope for treating the psychotic symptomologies in DLB and other human brain disorders.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Lethbridge NL,Chazot PL

doi

10.1016/j.phrs.2016.08.034

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

245-256

issue

Pt A

eissn

1043-6618

issn

1096-1186

pii

S1043-6618(16)30869-6

journal_volume

113

pub_type

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