Abstract：
:Duchenne muscular dystrophy (DMD) is a severe muscle disease of known etiology without effective, or generally applicable therapy. Mitochondria are affected by the disease in animal models but whether mitochondrial dysfunction is part of the pathogenesis in patients remains unclear. We show that primary cultures obtained from muscle biopsies of DMD patients display a decrease of the respiratory reserve, a consequence of inappropriate opening of the permeability transition pore (PTP). Treatment with the cyclophilin inhibitor alisporivir - a cyclosporin A derivative that desensitizes the PTP but does not inhibit calcineurin - largely restored the maximal respiratory capacity without affecting basal oxygen consumption in cells from patients, thus reinstating a normal respiratory reserve. Treatment with alisporivir, but not with cyclosporin A, led to a substantial recovery of respiratory function matching improved muscle ultrastructure and survival of sapje zebrafish, a severe model of DMD where muscle defects are close to those of DMD patients. Alisporivir was generally well tolerated in HCV patients and could be used for the treatment of DMD.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Schiavone M,Zulian A,Menazza S,Petronilli V,Argenton F,Merlini L,Sabatelli P,Bernardi Pdoi
10.1016/j.phrs.2017.09.001subject
Has Abstractpub_date
2017-11-01 00:00:00pages
122-131issue
Pt Beissn
1043-6618issn
1096-1186pii
S1043-6618(17)30938-6journal_volume
125pub_type
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journal_title：Pharmacological research
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