Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes.


:The aim of this study was to investigate effect of antiemetics on G6PD and antioxidant enzymes. Antiemetics are currently being used to reduce or prevent nausea and vomiting in patients. This is the first study to show effect of antiemetics on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities. For in vitro studies, G6PD was purified from human erythrocyte, 10, 26-fold in a yield of 51.3% by using ammonium sulphate precipitation and 2',5'-ADP-Sepharose 4B affinity gel. The purified enzyme showed a single band on sodium dodecyl sulfate-polyacrilamide gel electrophoresis (SDS-PAGE). The effects of four different antiemetics (granisetron hydrochloride, ondansetron hydrochloride, metoclopramide hydrochloride, trimethobenzamide hydrochloride) were investigated on the purified enzyme. Granisetron hydrochloride and ondansetron hydrochloride inhibited the enzyme activity (Ki values; 5.05 mM and 0.034 mM, I50 values; 3.9 mM and 0.036 mM, respectively). Metoclopramide hydrochloride, trimethobenzamide hydrochloride showed no inhibition effects. In addition, in vivo studies, effects of ondansetron hydrochloride on the G6PD, glutathione reductase (GR), glutathione peroxidase (GPx) and catalase (CAT) were examined in the rat erythrocytes. G6PD (49% of control), GR (55% of control), CAT (60% of control) activities in erythrocytes were significantly decreased whereas GPx (183% of control) was significantly increased. A marked alteration in these enzymes may be result of oxidative stress in the rats receiving ondansetron hydrochloride.


Pharmacol Res


Pharmacological research


Ozmen I,Küfrevioglu OI





Has Abstract


2004-11-01 00:00:00














  • Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury.

    abstract::Advanced glycation end products (AGEs) and their receptor (RAGE) axis contributes to diabetic nephropathy. An oral hypoglycemic agent, metformin may have a potential effect on the inhibition of glycation reactions. Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ishibashi Y,Matsui T,Takeuchi M,Yamagishi S

    更新日期:2012-03-01 00:00:00

  • A2BP1 gene polymorphisms association with olanzapine-induced weight gain.

    abstract::The ataxin-2 binding protein 1 (A2BP1) gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity. The aim of this study was to explore the association of A2BP1 gene polymorphisms with antipsychotic induced weight gain (AIWG) in Chinese Han population. Three hundred and twenty-eight p...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Dong L,Yan H,Huang X,Hu X,Yang Y,Ma C,Du B,Lu T,Jin C,Wang L,Yu H,Dong Z,Li W,Ruan Y,Zhang H,Zhang H,Mi W,Ma W,Li K,Lv L,Zhang D,Yue W

    更新日期:2015-09-01 00:00:00

  • A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment.

    abstract::A traditional Chinese medicine (TCM) formula (SL) comprising Sophorae Flos and Lonicerae Japonicae Flos was used for treating melanoma in ancient China. We have previously shown that an ethanolic extract of SL (SLE) possesses anti-melanoma effects and suppresses STAT3 signaling in vitro and in vivo. STAT3 has been lin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Liu YX,Bai JX,Li T,Fu XQ,Guo H,Zhu PL,Chan YC,Chou JY,Yin CL,Li JK,Wang YP,Chen YJ,Yu ZL

    更新日期:2019-04-01 00:00:00

  • Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.

    abstract::Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a corr...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Israelyan N,Margolis KG

    更新日期:2018-06-01 00:00:00

  • Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial.

    abstract::The polyphenol resveratrol is considered to exert many beneficial actions, such as antioxidant, anti-inflammatory, insulin-sensitizer and anticancer effects. Its benefits in patients with type 2 diabetes mellitus (T2DM) are controversial. Our aims were to determine whether resveratrol supplementation at two different ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,随机对照试验


    authors: Bo S,Ponzo V,Ciccone G,Evangelista A,Saba F,Goitre I,Procopio M,Pagano GF,Cassader M,Gambino R

    更新日期:2016-09-01 00:00:00

  • Simvastatin improves the attenuated heart rate recovery of type 2 diabetics.

    abstract::Heart rate recovery at 1min (HRR1) is a strong predictor of all-cause mortality. The effects of statins on the autonomic nervous system may account for their beneficial effects in survival. Our aim was to determine if statin therapy improves heart rate recovery in hypercholesterolemic patients with type 2 diabetes mel...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Tekin G,Tekin A,Canatar T,Sipahi I,Unsal A,Katircibaşi T,Koçum T,Erol T,Yiğit F,Demircan S,Ermiş N,Sezgin AT,Müderrisoğlu H

    更新日期:2006-12-01 00:00:00

  • P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil.

    abstract::Digoxin, which has a very narrow therapeutic window, is one of the most commonly prescribed drugs in the treatment of congestive heart failure. In some cases of atrial fibrillation digoxin is used in combination with verapamil. Verapamil can increase the plasma concentration of digoxin up to 60-90%. So far the precise...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Verschraagen M,Koks CH,Schellens JH,Beijnen JH

    更新日期:1999-10-01 00:00:00

  • Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system.

    abstract::Coronavirus Disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a crude case fatality rate of about 0.5-10 % depending on locality. A few clinically approved drugs, such as remdesivir, chloroquine, hydroxychloroquine, nafamostat, camostat, and ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yuan S,Chan JFW,Chik KKH,Chan CCY,Tsang JOL,Liang R,Cao J,Tang K,Chen LL,Wen K,Cai JP,Ye ZW,Lu G,Chu H,Jin DY,Yuen KY

    更新日期:2020-09-01 00:00:00

  • The distribution of catecholamines between plasma and platelets in cyclosporin A-induced hypertensive rats.

    abstract::One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Reis F,Tavares P,Teixeira F

    更新日期:2000-02-01 00:00:00

  • To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling.

    abstract::Sphingosine 1-phosphate (S1P) is an extracellular lipid signaling molecule that acts as a selective, high-affinity ligand for a family of five G protein-coupled receptors. This signaling system was first identified twenty years ago, and has since been shown to regulate a diverse range of physiological processes and di...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Chew WS,Wang W,Herr DR

    更新日期:2016-11-01 00:00:00

  • The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.

    abstract::In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining. Moreover, the relationship between Bcl-2, iNOS expression, and serum nitrate (NO(3)(-)) ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cinel I,Buyukafsar K,Cinel L,Polat A,Atici S,Tamer L,Oral U

    更新日期:2002-08-01 00:00:00

  • Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia.

    abstract::CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

    更新日期:2014-03-01 00:00:00

  • High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients.

    abstract::Moderate wine consumption has been shown to reduce cardiovascular (CV) risk, due to alcohol and polyphenolic compounds, such as resveratrol. We investigated the associations between total urinary resveratrol metabolites (TRMs) as biomarkers of wine and resveratrol consumption and CV risk factors in a large cross-secti...

    journal_title:Pharmacological research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zamora-Ros R,Urpi-Sarda M,Lamuela-Raventós RM,Martínez-González MÁ,Salas-Salvadó J,Arós F,Fitó M,Lapetra J,Estruch R,Andres-Lacueva C,PREDIMED Study Investigators.

    更新日期:2012-06-01 00:00:00

  • Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways.

    abstract::Osteopontin (OPN) is known as an active player in the progression of vascular remodeling diseases, however, the precise role in the proliferation of vascular smooth muscle cells (VSMC) is unclear. Thus, this study investigated the role of OPN in VSMC proliferation induced by 4-hydroxynonenal (HNE), and identified the ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lee SJ,Baek SE,Jang MA,Kim CD

    更新日期:2016-06-01 00:00:00

  • Bisoprolol and hydrochlorothiazide effects on cardiovascular remodeling in spontaneously hypertensive rats.

    abstract::Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mougenot N,Médiani O,Lechat P

    更新日期:2005-04-01 00:00:00

  • Pediatric drug development in China: Reforms and challenges.

    abstract::In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study,we introduced the current ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Wu W,Tang Z,Chen J,Gao Y

    更新日期:2019-10-01 00:00:00

  • Pharmacological studies of cardamom oil in animals.

    abstract::Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: al-Zuhair H,el-Sayeh B,Ameen HA,al-Shoora H

    更新日期:1996-07-01 00:00:00

  • Anti-inflammatory activity of monomethoxypolyethylene glycol superoxide dismutase on adjuvant arthritis in rats.

    abstract::In previous studies we observed an enhanced anti-inflammatory activity of MPEG-SOD derivatives in acute inflammation in rat. To assess the activity in chronic inflammation we tested the compound with longer half-life (MPEG-SOD 18) in complete adjuvant arthritis in rat. According to the prophylactic schedule of treatme...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Conforti A,Caliceti P,Sartore L,Schiavon O,Veronese F,Velo GP

    更新日期:1991-01-01 00:00:00

  • Effect of vitamins C and E on cognitive function in mouse.

    abstract::The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Arzi A,Hemmati AA,Razian A

    更新日期:2004-03-01 00:00:00

  • Direct inotropic effects of propofol and adenosine on rat atrial muscle: possible mechanisms.

    abstract::Experiments were designed to evaluate the mechanisms of propofol and adenosine in rat atrial muscle. Atria were suspended in the isolated organ bath system for isometric tension recording and response to propofol and adenosine were tested in the absence and presence of glibenclamide, N(G)-nitro-arginine-methyl-ester (...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cinel I,Gür S

    更新日期:2000-08-01 00:00:00

  • The potentiation of the histamine release induced by adenosine in mast cells from guinea pig lung and heart: sharp dependence on the time of preincubation.

    abstract::We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Campos BG,Ferreira RR,Gomes JC

    更新日期:2000-03-01 00:00:00

  • Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.

    abstract::Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increas...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zheng L,Han X,Hu Y,Zhao X,Yin L,Xu L,Qi Y,Xu Y,Han X,Liu K,Peng J

    更新日期:2019-01-01 00:00:00

  • The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain.

    abstract::There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

    更新日期:2016-09-01 00:00:00

  • Redundant down-regulation pathways for p53.

    abstract::The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and ac...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Cinelli M,Magnelli L,Chiarugi V

    更新日期:1998-02-01 00:00:00

  • Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader.

    abstract::Breast cancer, the most prevalent cancer in women, remains the second in the list of cancer mortality, the majority of these fatalities resulted from estrogen receptor alpha (ERα) positive disease. ERα is well known for its function on breast cancer initiation and development and has become the most successful biomark...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao Y,Zhao C,Lu J,Wu J,Li C,Hu Z,Tian W,Yang L,Xiang J,Zhou H,Deng Z,Huang J,Hong K

    更新日期:2019-08-01 00:00:00

  • Boosting immunity to treat parasitic infections: Asaia bacteria expressing a protein from Wolbachia determine M1 macrophage activation and killing of Leishmania protozoans.

    abstract::Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

    更新日期:2020-11-01 00:00:00

  • Possible involvement of opioid receptors in moclobemide-induced hypothermia in mice.

    abstract::Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ginawi OT

    更新日期:2003-09-01 00:00:00

  • Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives.

    abstract::Chrysin, a natural flavone compound found in plants, has anti-inflammatory activity that has been previously explained in part by the suppression of promoter activities of pro-inflammatory enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Here we present evidence that several chrysin deriva...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cho H,Yun CW,Park WK,Kong JY,Kim KS,Park Y,Lee S,Kim BK

    更新日期:2004-01-01 00:00:00

  • Diabetes differentially modulated receptor- and non-receptor-mediated relaxation in rat renal artery.

    abstract::In this study, we have investigated the vasodilator response to acetylcholine under diabetic conditions in isolated renal arteries of Wistar rats. The effect of nitric oxide synthase (NOS) inhibition on acetylcholine-induced vasodilator response was investigated. We have also examined the effects of two endothelium-de...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yousif MH

    更新日期:2003-09-01 00:00:00

  • Testicular toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q10 and L-carnitine in mice.

    abstract::The protective effect of L-carnitine or coenzyme Q10 (CoQ10) against high magnetic field (20 mT) induced testicular toxicity in mice were evaluated. Animals were injected with L-carnitine (200 mg kg(-1), i.p.) or CoQ10 (200 mg kg(-1), p.o.) 1h before exposure to fractionated doses (30 min per day, three times per week...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ramadan LA,Abd-Allah AR,Aly HA,Saad-el-Din AA

    更新日期:2002-10-01 00:00:00