Abstract：
:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic diseases, exerts anti-diabetic, anti-atherogenic and anti-inflammatory activities. Due to these positive actions, the role of adiponectin in cardiovascular protection has been evaluated in recent years. In particular, for its potential therapeutic benefits in humans, adiponectin has become the subject of intense preclinical research. In the cardiovascular context, understanding of the cellular and molecular mechanisms underlying the adiponectin system, throughout its secretion, regulation and signaling, is critical for designing new drugs that target adiponectin system molecules. This review focused on recent advances regarding molecular mechanisms related to protective effects of the adiponectin system on both cardiac and vascular compartments and its potential use as a target for therapeutic intervention of CVD.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi Ddoi
10.1016/j.phrs.2014.03.003subject
Has Abstractpub_date
2014-04-01 00:00:00pages
9-20eissn
1043-6618issn
1096-1186pii
S1043-6618(14)00026-7journal_volume
82pub_type
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pub_type： 杂志文章,评审
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更新日期：1991-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
