Back to the heart: the protective role of adiponectin.


:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic diseases, exerts anti-diabetic, anti-atherogenic and anti-inflammatory activities. Due to these positive actions, the role of adiponectin in cardiovascular protection has been evaluated in recent years. In particular, for its potential therapeutic benefits in humans, adiponectin has become the subject of intense preclinical research. In the cardiovascular context, understanding of the cellular and molecular mechanisms underlying the adiponectin system, throughout its secretion, regulation and signaling, is critical for designing new drugs that target adiponectin system molecules. This review focused on recent advances regarding molecular mechanisms related to protective effects of the adiponectin system on both cardiac and vascular compartments and its potential use as a target for therapeutic intervention of CVD.


Pharmacol Res


Pharmacological research


Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi D




Has Abstract


2014-04-01 00:00:00












  • Viral G protein-coupled receptors as modulators of cancer hallmarks.

    abstract::Herpesviruses encode transmembrane G protein-coupled receptors (GPCRs), which share structural homology to human chemokine receptors. These viral GPCRs include KSHV-encoded ORF74, EBV-encoded BILF1, and HCMV-encoded US28, UL33, UL78 and US27. Viral GPCRs hijack various signaling pathways and cellular networks, includi...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: van Senten JR,Fan TS,Siderius M,Smit MJ

    更新日期:2020-06-01 00:00:00

  • Reversible binding of celecoxib and valdecoxib with human serum albumin using fluorescence spectroscopic technique.

    abstract::Mechanism of interaction of non-steroidal anti-inflammatory drugs, celecoxib and valdecoxib with human serum albumin has been studied using fluorescence spectroscopic technique. There was only one high affinity site on serum albumin for both the drugs with association constants of the order of 10(4) in the case of cel...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Seedher N,Bhatia S

    更新日期:2006-08-01 00:00:00

  • Anti-cancerous efficacy and pharmacokinetics of 6-mercaptopurine loaded chitosan nanoparticles.

    abstract::6-Mercaptopurine is a cytotoxic and immunosuppressant drug. The use of this drug is limited due to its poor bioavailability and short plasma half-life. In order to nullify these drawbacks, 6-mercaptopurine-chitosan nanoparticles (6-MP-CNPs) were prepared and evaluated to study the influence of preparation conditions o...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kumar GP,Sanganal JS,Phani AR,Manohara C,Tripathi SM,Raghavendra HL,Janardhana PB,Amaresha S,Swamy KB,Prasad RG

    更新日期:2015-10-01 00:00:00

  • Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.

    abstract::Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increas...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zheng L,Han X,Hu Y,Zhao X,Yin L,Xu L,Qi Y,Xu Y,Han X,Liu K,Peng J

    更新日期:2019-01-01 00:00:00

  • Pharmacokinetics of doxycycline after administration as a single intravenous bolus and intramuscular doses to non-lactating Egyptian goats.

    abstract::The pharmacokinetics of doxycycline hydrochloride (DoxHcl) at a dose of 5 mg kg-1 BW was studied after an intravenous (i.v.) bolus and intramuscular (i.m.) injections in non lactating goats. A microbiological assay employing Bacillus subtilis as the test organism was used to measure its concentrations in serum and uri...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Abd El-Aty AM,Goudah A,Zhou HH

    更新日期:2004-05-01 00:00:00

  • Therapeutic effects of I(f) blockade: evidence and perspective.

    abstract::Heart rate slowing has been accepted for decades as a primary therapeutic approach to prevention (and even to treatment) of angina pectoris. Pure heart rate slowing has not been achieved with previously available rate-slowing pharmacological agents (beta adrenergic blockers, certain calcium channel blockers), all of w...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Borer JS

    更新日期:2006-05-01 00:00:00

  • Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus.

    abstract::The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied. The results show that EEP and WSD led to decreased levels of blood glucose (FBG), fructosamine (FRU), malonaldehyde (MDA), nitric oxi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Fuliang HU,Hepburn HR,Xuan H,Chen M,Daya S,Radloff SE

    更新日期:2005-02-01 00:00:00

  • Behavioural activity of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors.

    abstract::The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly att...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zalewska-Wińska A,Wiśniewski K

    更新日期:2000-09-01 00:00:00

  • More than just an enzyme: Dipeptidyl peptidase-4 (DPP-4) and its association with diabetic kidney remodelling.

    abstract:PURPOSE OF THE REVIEW:This review article discusses recent advances in the mechanism of dipeptidyl peptidase-4 (DPP-4) actions in renal diseases, especially diabetic kidney fibrosis, and summarizes anti-fibrotic functions of various DPP-4 inhibitors in diabetic nephropathy (DN). RECENT FINDINGS:DN is a common complica...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gupta S,Sen U

    更新日期:2019-09-01 00:00:00

  • The role of PPARs in modulating cardiac metabolism in diabetes.

    abstract::Diabetes mellitus is an important risk factor for the development of cardiovascular disease. The impact of diabetes on the heart in part resides in the changes in metabolic fuel availability evoked by lack of insulin or resistance to its action. This review addresses how the metabolic abnormalities associated with poo...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Holness MJ,Samsuddin S,Sugden MC

    更新日期:2009-09-01 00:00:00

  • Meta-analysis on outcome-worsening comorbidities of COVID-19 and related potential drug-drug interactions.

    abstract::Drug-drug interactions (DDI) potentially occurring between medications used in the course of COVID-19 infection and medications prescribed for the management of underlying comorbidities may cause adverse drug reactions (ADRs) contributing to worsening of the clinical outcome in affected patients. First, we conducted a...

    journal_title:Pharmacological research

    pub_type: 杂志文章,meta分析


    authors: Awortwe C,Cascorbi I

    更新日期:2020-11-01 00:00:00

  • Role of heterogeneous regulatory T cells in the tumor microenvironment.

    abstract::Regulatory T cells (Tregs) modulate ongoing immune responses to prevent autoimmunity in healthy bodies and inhibit effective anti-tumor immunity responses in tumor patients, leading to tumor progression. The function of Tregs in tumor immunity suggests that elimination of Tregs in the host may enhance the anti-tumor i...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Wei T,Zhong W,Li Q

    更新日期:2020-03-01 00:00:00

  • Activation of angiotensin II type-2 receptor protects against cigarette smoke-induced COPD.

    abstract::Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mei D,Tan WSD,Liao W,Heng CKM,Wong WSF

    更新日期:2020-11-01 00:00:00

  • Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions.

    abstract::Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Shimomura Y,Kitaura Y

    更新日期:2018-07-01 00:00:00

  • Risk of bradyarrhythmia related to ticagrelor: A systematic review and meta-analysis.

    abstract:CONTEXT:Ticagrelor was related to bradycardia in DISPERSE-II trial. This risk has been integrated into the European risk-management plan, and its use is warned in at-risk patients. Nevertheless, this risk was not systematically assessed nor measured. OBJECTIVES:To estimate the risk of bradyarrhythmia associated with t...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pujade I,Perino J,Mathieu C,Arnaud M,Raschi E,Gatti M,Bezin J,Salvo F

    更新日期:2020-10-01 00:00:00

  • Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.

    abstract::Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

    更新日期:2005-06-01 00:00:00

  • Heart remodeling induced by adjuvant trastuzumab-containing chemotherapy for breast cancer overexpressing human epidermal growth factor receptor type 2: a prospective study.

    abstract::We aimed to investigate the cardiac changes in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with trastuzumab in an adjuvant setting. Two hundred and fifty-three women with HER2-positive breast cancer were included. The assessment of cardiovascular system and echocardiogr...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Piotrowski G,Gawor R,Bourge RC,Stasiak A,Potemski P,Gawor Z,Nanda NC,Banach M

    更新日期:2013-12-01 00:00:00

  • Newer agents for coronary thrombolysis. Perspectives from clinical studies.

    abstract::Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

    更新日期:1989-03-01 00:00:00

  • Advances into Understanding the Vital Role of the Mitochondrial Citrate Carrier (CIC) in Metabolic Diseases.

    abstract::The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found i...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Peng R,Zhang M,Wang H,Lin J,Wang H,Wang F,Liu L,Zhao Q,Liu J

    更新日期:2020-11-01 00:00:00

  • Funny channels in the control of cardiac rhythm and mode of action of selective blockers.

    abstract::"Funny" (f) channels underlie the cardiac "pacemaker"I(f) current, originally described as an inward current activated on hyperpolarization to the diastolic range of voltages in sino-atrial node myocytes [Brown, HF, DiFrancesco, D, Noble, SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236]. The invo...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: DiFrancesco D

    更新日期:2006-05-01 00:00:00

  • The future (or lack of future) of personalized prescription in psychiatry.

    abstract::Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the con...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: de Leon J

    更新日期:2009-02-01 00:00:00

  • Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.

    abstract::Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphor...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Lee C,Rhee I

    更新日期:2019-06-01 00:00:00

  • Effects of nifedipine and Bay K 8644 on the R-PIA and caffeine-induced changes in the locomotor activity of rats.

    abstract::Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Eroglu L,Tuna R,Caglayan B

    更新日期:1996-02-01 00:00:00

  • Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia.

    abstract::CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

    更新日期:2014-03-01 00:00:00

  • Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader.

    abstract::Breast cancer, the most prevalent cancer in women, remains the second in the list of cancer mortality, the majority of these fatalities resulted from estrogen receptor alpha (ERα) positive disease. ERα is well known for its function on breast cancer initiation and development and has become the most successful biomark...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao Y,Zhao C,Lu J,Wu J,Li C,Hu Z,Tian W,Yang L,Xiang J,Zhou H,Deng Z,Huang J,Hong K

    更新日期:2019-08-01 00:00:00

  • Notch in fibrosis and as a target of anti-fibrotic therapy.

    abstract::The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseas...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Hu B,Phan SH

    更新日期:2016-06-01 00:00:00

  • Cytochrome P450 epoxygenases as EDHF synthase(s).

    abstract::The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is n...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Fleming I

    更新日期:2004-06-01 00:00:00

  • Possible involvement of opioid receptors in moclobemide-induced hypothermia in mice.

    abstract::Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ginawi OT

    更新日期:2003-09-01 00:00:00

  • Allosteric modulation of sigma receptors by BH3 mimetics ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax).

    abstract::ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax) are under intensive preclinical and clinical investigation as treatments for hematologic and other malignancies. These small molecules mimic pro-death B-cell lymphoma-2 (Bcl-2) Homology 3 (BH3) domain-only proteins. They also bear a structural resemblance to certa...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lever JR,Fergason-Cantrell EA

    更新日期:2019-04-01 00:00:00

  • The pharmacokinetics of tricyclic antidepressant drugs in the elderly.

    abstract::Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Furlanut M,Benetello P

    更新日期:1990-01-01 00:00:00