Is the clinical relevance of drug-food and drug-herb interactions limited to grapefruit juice and Saint-John's Wort?

abstract：:Hydrogen sulfide (H2S) is an endogenously produced signaling molecule synthesized by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). Given that H2S exerts significant effects on bioenergetics and metabolism, the goal of the current study was to determine th...

journal_title：Pharmacological research

authors： Katsouda A,Szabo C,Papapetropoulos A

更新日期：2018-02-01 00:00:00

abstract：:We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CB1 antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 a...

journal_title：Pharmacological research

authors： Mastinu A,Pira M,Pinna GA,Pisu C,Casu MA,Reali R,Marcello S,Murineddu G,Lazzari P

更新日期：2013-08-01 00:00:00

abstract：:The study was undertaken using selected pharmacodynamic parameters to describe the effects of porcine galanin(1-29)-NH2; porcine galanin fragments; galantide; porcine galanin(1-14)-[alpha-aminobutyric acid8]scyliorhinin-I and the analogues of the latter peptides on rat isolated gastric fundus muscle. All tested peptid...

journal_title：Pharmacological research

authors： Korolkiewicz R,Sliwiński W,Rekowski P,Halama-Borowiec A,Mucha P,Szczurowicz A,Korolkiewicz KZ

更新日期：1997-01-01 00:00:00

abstract：:Ranolazine has characteristic properties of a selective inhibitor of the inward sodium current. It is primarily indicated as an anti-anginal agent in patients with coronary artery disease and chronic stable angina. Recently, ranolazine has been noted to possibly impart beneficial effects in various other cardiac condi...

journal_title：Pharmacological research

authors： Mihos CG,Krishna RK,Kherada N,Larrauri-Reyes M,Tolentino A,Santana O

更新日期：2016-01-01 00:00:00

abstract：:Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

journal_title：Pharmacological research

authors： Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

更新日期：2005-03-01 00:00:00

abstract：:Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphor...

journal_title：Pharmacological research

authors： Lee C,Rhee I

更新日期：2019-06-01 00:00:00

abstract：:We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...

journal_title：Pharmacological research

authors： Villa V,Thellung S,Bajetto A,Gatta E,Robello M,Novelli F,Tasso B,Tonelli M,Florio T

更新日期：2016-11-01 00:00:00

abstract：:Asthma and COPD make up the majority of obstructive airways diseases (OADs), which affects ∼11 % of the population. The main drugs used to treat OADs have not changed in the past five decades, with advancements mainly comprising variations on existing treatments. The recent biologics are beneficial to only specific su...

journal_title：Pharmacological research

authors： Chapman DG,King GG,Robinson PD,Farah CS,Thamrin C

更新日期：2020-09-01 00:00:00

abstract：:Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over decades, only a few drugs were approved by Food and Drug Administration (FDA) and most ended in failure. The lessons learned have switched the strategy of drug discovery from designing highly selective ligands to a network pharm...

journal_title：Pharmacological research

authors： Huang L,Wang S,Ma F,Zhang Y,Peng Y,Xing C,Feng Y,Wang X,Peng Y

更新日期：2018-09-01 00:00:00

abstract：:A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...

journal_title：Pharmacological research

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-11-01 00:00:00

abstract：:Perfusion of all mammalian heart muscle except hamster with Ca(2+)-free Tyrode and thereafter reperfusion with normal Tyrode causes irreversible damage, the calcium paradox. Our study aims at deciphering the role of creatine kinase, high energy phosphates and Ca(2+)influx in the genesis of myocardial injury in the rat...

journal_title：Pharmacological research

authors： Ray M,Roy R,Chowdhury PD,Srivastava S,Dubey MP

更新日期：2000-03-01 00:00:00

abstract：:In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted a...

journal_title：Pharmacological research

authors： Pistollato F,Forbes-Hernández TY,Calderón Iglesias R,Ruiz R,Elexpuru Zabaleta M,Cianciosi D,Giampieri F,Battino M

更新日期：2020-02-01 00:00:00

abstract：:Though the AMPA receptor has been implicated in several neurodegenerative processes (epilepsy, ischemia, spasticity), its role in cognition is yet to be clarified. The aim of this study was to assess in the rat the effects of the AMPA receptor antagonist NBQX (3.5, 7, 10, 20 and 30 mgkg(-1), i.p.) on learning and memo...

journal_title：Pharmacological research

authors： Pitsikas N,Rigamonti AE,Cella SG,Muller EE

更新日期：2002-01-01 00:00:00

abstract：:The present study was designed to investigate the ameliorative potential of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, in tibial and sural nerve transection-induced neuropathic pain in rats. The pinprick, cold immersion, hot plate and hot immersion tests were performed to a...

journal_title：Pharmacological research

authors： Jain V,Jaggi AS,Singh N

更新日期：2009-06-01 00:00:00

abstract：:Tissue subjected to a period of ischemia undergoes functional and morphological damage that increases during the reperfusion phase. In this study, the protective effect of aprotinin, which is a protease inhibitor, was assessed in a rabbit unilateral renal ischemia-reperfusion (I/R) model. New Zealand rabbits, weighing...

journal_title：Pharmacological research

authors： Ozer Z,Sucu N,Düşmez D,Tamer L,Altunkan AA,DIkmengIl M,Oral U

更新日期：2001-12-01 00:00:00

abstract：:Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

journal_title：Pharmacological research

authors： Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

更新日期：2005-06-01 00:00:00

abstract：:Since the regenerative capacity of the adult mammalian heart is limited, cardiac injury leads to the formation of scar tissue and thereby increases the risk of developing compensatory heart failure. Stem cell therapy is a promising therapeutic approach but is facing problems with engraftment and clinical feasibility. ...

journal_title：Pharmacological research

authors： Smits AM,Dronkers E,Goumans MJ

更新日期：2018-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (...

journal_title：Pharmacological research

authors： Mei D,Tan WSD,Liao W,Heng CKM,Wong WSF

更新日期：2020-11-01 00:00:00

abstract：:We compared the protective abilities of Mangifera indica L. stem bark extract (Vimang) 50-250 mgkg(-1), mangiferin 50 mgkg(-1), vitamin C 100 mgkg(-1), vitamin E 100 mgkg(-1)and beta -carotene 50 mgkg(-1)against the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage in serum, liver, brain as well as i...

journal_title：Pharmacological research

authors： Sánchez GM,Re L,Giuliani A,Núñez-Sellés AJ,Davison GP,León-Fernández OS

更新日期：2000-12-01 00:00:00

abstract：:The mechanism for the pathological increase in cell death in various disease states e.g. HIV immunodefficiency or even ageing or Alzheimer's disease, occurs by complex and as yet undefined mechanism(s) related to immunological, virological or biochemical disturbances (i.e. energy depletion, oxidative stress, increased...

journal_title：Pharmacological research

authors： Virmani MA,Biselli R,Spadoni A,Rossi S,Corsico N,Calvani M,Fattorossi A,De Simone C,Arrigoni-Martelli E

更新日期：1995-12-01 00:00:00

abstract：:The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faec...

journal_title：Pharmacological research

authors： Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

更新日期：1993-01-01 00:00:00

abstract：:Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

journal_title：Pharmacological research

authors： Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

更新日期：2020-11-01 00:00:00

abstract：:Etifoxine (EFX) is a non-benzodiazepine psychoactive drug which exhibits anxiolytic effects through a dual mechanism, by directly binding to GABAA receptors (GABAARs) and to the mitochondrial 18-kDa translocator protein, resulting in the potentiation of the GABAergic function. The β subunit subtype plays a key role in...

journal_title：Pharmacological research

authors： Mattei C,Taly A,Soualah Z,Saulais O,Henrion D,Guérineau NC,Verleye M,Legros C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...

journal_title：Pharmacological research

authors： Korolkiewicz RP,Tashima K,Fujita A,Kato S,Takeuchi K

更新日期：2000-02-01 00:00:00

abstract：:Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...

journal_title：Pharmacological research

authors： Xu L,Li Y,Dai Y,Peng J

更新日期：2018-04-01 00:00:00

abstract：:Oxidative stress is an important contributor to the risk of chronic diseases. Dietary guidelines recommend increased consumption of fruits and vegetables to combat the incidence of human diseases such as cancer, cardiovascular disease, osteoporosis and diabetes. Fruits and vegetables are good sources of antioxidant ph...

journal_title：Pharmacological research

authors： Rao AV,Rao LG

更新日期：2007-03-01 00:00:00

abstract：:The activity of short porcine galanin (Gal) analogues was tested in vitro using rat gastric fundus strips. The peptides contracted longitudinal smooth muscle in a concentration-dependent manner with the following order of potency: Gal(1-29) >[Cit(14)]Gal(1- 15) >[Asp(14)]Gal(1- 15) >[Dab(14)]Gal(1- 15) >[Nle(14)] Gal(...

journal_title：Pharmacological research

authors： Korolkiewicz RP,Konstański Z,Rekowski P,Ruczyński J,Szyk A,Dabkowski J,Ujda M,Korolkiewicz KZ,Petrusewicz J

更新日期：2001-07-01 00:00:00

abstract：:Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

journal_title：Pharmacological research

authors： Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

更新日期：2000-07-01 00:00:00

abstract：:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses c...

journal_title：Pharmacological research

authors： Costa Queiroz RH,de Souza AM,Sampaio SV,Melchior E Jr

更新日期：2002-08-01 00:00:00

abstract：:As a function of the structural modification of the steroid nucleus, the inhibitory interaction of 11 progesterone derivatives with human Na/K-ATPase (Na+/K(+)-transporting ATPase, EC 3.6.1.37), through C3-O-rhamnosylation, is either much decreased or weakly up to strongly increased, so that the rhamnosyl residue cont...

journal_title：Pharmacological research

authors： Weiland J,Schönfeld W,Menke KH,Repke KR

更新日期：1991-01-01 00:00:00