Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.


:Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. induced by oxygen radicals released during inflammation. Thus, administration of HBP as an adjunct to antibiotics increased survival of mice with peritonitis. In the present study, the effects of recombinant HBP as an adjunct to standard antibiotics were examined in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia. Beneficial and possible adverse effects of HBP were evaluated clinically and pathologically as well as by measurement of clinical chemical variables and markers of inflammation (interleukin-6 and C-reactive protein) and oxidative stress (ascorbic acid and alpha-tocopherol). Pigs receiving HBP (0.55 mgkg-1, n=11) as a 6-hourly subcutaneous infusion starting 1-h post-infection had a faster decrease in rectal temperature compared to control animals receiving a carrier-infusion (n=11), with a significant lower temperature at 32 h post-infection (p<0.05). This difference was, however, transient and the temperature curves had a similar course from 38 h and onwards. The transient effect of HBP might be explained by the dosage regimen that was used. No signs of adverse effects of the HBP-infusion were observed. More studies are needed to elucidate of the effects of HBP further and to optimise the dosage regimen for further improvement the efficacy and safety.


Pharmacol Res


Pharmacological research


Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O





Has Abstract


2005-06-01 00:00:00














  • NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodies.

    abstract::Nerve growth factor (NGF) is the prototype of the neurotrophin family and promotes the survival of specific populations of neurons, stimulates their morphological differentiation and regulates neuronal gene expression. Since its discovery, NGF attracted clinicians for its potential application in the treatment of neur...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Lambiase A,Coassin M,Sposato V,Micera A,Sacchetti M,Bonini S,Aloe L

    更新日期:2007-07-01 00:00:00

  • The effects of dexamethasone on lipid peroxidation and nitric oxide levels on the healing of tracheal anastomoses: an experimental study in rats.

    abstract::Corticosteroids are shown to have deleterious effects on wound healing for various tissues. Arginine metabolism and nitric oxide (NO) synthesis play an important role in many aspects of inflammation and wound healing. The study was designed to evaluate the relationship of dexamethasone impaired healing of tracheal ana...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Talas DU,Nayci A,Polat G,Atis S,Comelekoglu U,Bagdatoglu OT,Bagdatoglu C

    更新日期:2002-09-01 00:00:00

  • Circadian clock: Time for novel anticancer strategies?

    abstract::Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi B

    更新日期:2015-10-01 00:00:00

  • Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives.

    abstract::Chrysin, a natural flavone compound found in plants, has anti-inflammatory activity that has been previously explained in part by the suppression of promoter activities of pro-inflammatory enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Here we present evidence that several chrysin deriva...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cho H,Yun CW,Park WK,Kong JY,Kim KS,Park Y,Lee S,Kim BK

    更新日期:2004-01-01 00:00:00

  • Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells.

    abstract::Nebivolol, a third generation selective beta(1)-adrenoceptor (beta(1)-AR) antagonist, has been reported to reduce intracellular oxidative stress and to induce the release of nitric oxide (NO) from the endothelium. Nebivolol is also subjected to a complex metabolic process where glucuronidation, aromatic and alicyclic ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Evangelista S,Garbin U,Pasini AF,Stranieri C,Boccioletti V,Cominacini L

    更新日期:2007-04-01 00:00:00

  • Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice.

    abstract::We compared the protective abilities of Mangifera indica L. stem bark extract (Vimang) 50-250 mgkg(-1), mangiferin 50 mgkg(-1), vitamin C 100 mgkg(-1), vitamin E 100 mgkg(-1)and beta -carotene 50 mgkg(-1)against the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage in serum, liver, brain as well as i...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sánchez GM,Re L,Giuliani A,Núñez-Sellés AJ,Davison GP,León-Fernández OS

    更新日期:2000-12-01 00:00:00

  • Reversible binding of celecoxib and valdecoxib with human serum albumin using fluorescence spectroscopic technique.

    abstract::Mechanism of interaction of non-steroidal anti-inflammatory drugs, celecoxib and valdecoxib with human serum albumin has been studied using fluorescence spectroscopic technique. There was only one high affinity site on serum albumin for both the drugs with association constants of the order of 10(4) in the case of cel...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Seedher N,Bhatia S

    更新日期:2006-08-01 00:00:00

  • Cholinesterase inhibitors: new roles and therapeutic alternatives.

    abstract::An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Giacobini E

    更新日期:2004-10-01 00:00:00

  • Cyproterone acetate and reversal of the impaired endometrial decidualization in streptozotocin-diabetic pseudopregnant rats.

    abstract::Reproductive dysfunction in the female diabetic rat is associated with impaired hypothalamic-hypophyseal system, anovulation, insufficiency of ovarian steroidogenesis and spontaneous failure of pregnancy. Formation of decidua, the highly modified endometrium of pregnancy and pseudopregnancy could only be achieved when...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zakaria R,Ismail Z,Chatterjee A

    更新日期:2000-08-01 00:00:00

  • A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19).

    abstract::The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization (WHO), and its harm degree is defined as a global "pandemic". At present, the efforts of various countries focus on the rapid di...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Huang F,Li Y,Leung EL,Liu X,Liu K,Wang Q,Lan Y,Li X,Yu H,Cui L,Luo H,Luo L

    更新日期:2020-08-01 00:00:00

  • Dopaminergic projection to the septum mediates facilitatory effect of angiotensins on recognition memory in rats.

    abstract::We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition me...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Winnicka MM,Braszko JJ,Wiśniewski K

    更新日期:1997-11-01 00:00:00

  • Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives.

    abstract::Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gambardella A,Labate A,Cifelli P,Ruffolo G,Mumoli L,Aronica E,Palma E

    更新日期:2016-11-01 00:00:00

  • Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice.

    abstract::Our goal was to establish the requirement of β3 adrenoceptor (β3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and β3Adr knockout (KO) male mice fed with a standard diet or a high-fat diet (HFD/16 weeks) treated or not with GT (0.5 g/kg of body weig...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sousa-Filho CPB,Faria HOF,Esposito JC,Melo A,Ribeiro MO,Otton R

    更新日期:2020-09-01 00:00:00

  • A2BP1 gene polymorphisms association with olanzapine-induced weight gain.

    abstract::The ataxin-2 binding protein 1 (A2BP1) gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity. The aim of this study was to explore the association of A2BP1 gene polymorphisms with antipsychotic induced weight gain (AIWG) in Chinese Han population. Three hundred and twenty-eight p...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Dong L,Yan H,Huang X,Hu X,Yang Y,Ma C,Du B,Lu T,Jin C,Wang L,Yu H,Dong Z,Li W,Ruan Y,Zhang H,Zhang H,Mi W,Ma W,Li K,Lv L,Zhang D,Yue W

    更新日期:2015-09-01 00:00:00

  • Pharmacological characterization of isoproterenol-treated medaka fish.

    abstract::The transparent bodies of see-through medaka fish has led to their use as models for in vivo cell and tissue imaging. However, these fish may also prove useful as models for pathological processes. Accumulating reports show that pathology in fish is similar to that in mammals, including humans. In this study, patholog...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kawasaki T,Saito K,Deguchi T,Fujimori K,Tadokoro M,Yuba S,Ohgushi H,Kawarabayasi Y

    更新日期:2008-11-01 00:00:00

  • Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle.

    abstract::Sepsis induced myocardial dysfunction (SIMD) results in high morbidity and mortality. However, the effective therapeutic strategies for SIMD treatment remain limited. Sirt3 is the main mitochondrial Sirtuin member and is a key modulator of mitochondrial metabolism and function. In this study, we aimed to investigate t...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xu Y,Zhang S,Rong J,Lin Y,Du L,Wang Y,Zhang Z

    更新日期:2020-09-01 00:00:00

  • Co-administration of raltegravir reduces daily darunavir exposure in HIV-1 infected patients.

    abstract::The potential drug-to-drug interaction between darunavir and raltegravir in the setting of HIV infection is a highly debated issue still unresolved. In the present study we have evaluated the pharmacokinetics of darunavir and ritonavir in 53 HIV-1 infected patients with or without concomitant raltegravir administratio...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Cattaneo D,Gervasoni C,Cozzi V,Baldelli S,Fucile S,Meraviglia P,Landonio S,Boreggio G,Rizzardini G,Clementi E

    更新日期:2012-02-01 00:00:00

  • Effect of anti-tumor necrosis factor-alpha therapies on body mass index in patients with psoriasis.

    abstract::Psoriasis is a lifelong, chronic and immune-mediated skin disease affecting approximately 1-3% of the Caucasian population. Pathogenesis of psoriasis is associated with an increased expression of tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a pro-inflammatory cytokine and important mediator of cachexia. Anti-...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Saraceno R,Schipani C,Mazzotta A,Esposito M,Di Renzo L,De Lorenzo A,Chimenti S

    更新日期:2008-04-01 00:00:00

  • Behavioural activity of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors.

    abstract::The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly att...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zalewska-Wińska A,Wiśniewski K

    更新日期:2000-09-01 00:00:00

  • Nerve growth factor enhances cough via a central mechanism of action.

    abstract::The mechanisms involved in enhanced cough induced by central and inhaled NGF in guinea pigs were investigated. Cough and airway function were assessed by plethysmography following inhaled or intracerebroventricular (i.c.v.) NGF treatment. Expression of TrkA and/or TRPV1 was determined in bronchi and/or brainstem by re...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: El-Hashim AZ,Jaffal SM,Al-Rashidi FT,Luqmani YA,Akhtar S

    更新日期:2013-08-01 00:00:00

  • Effect of ursodeoxycholic acid administration on bile acid composition in hamster bile.

    abstract::The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Matejka M,Vescina C,Carducci CN,Alayón A,Dios A,Scarlatto E,Mamianetti A

    更新日期:1990-05-01 00:00:00

  • The pathogenesis of renal injury in obstructive jaundice: A review of underlying mechanisms, inducible agents and therapeutic strategies.

    abstract::Kidney injury is one of the main complications of obstructive jaundice (OJ) and its pathogenesis has not been clarified. As an independent risk factor for OJ associated with significant morbidity and mortality, it can be mainly divided into two types of morphological injury and functional injury. We called these dysfu...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Liu J,Qu J,Chen H,Ge P,Jiang Y,Xu C,Chen H,Shang D,Zhang G

    更新日期:2021-01-01 00:00:00

  • Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?

    abstract::Carbon-based nanomaterials have unique physicochemical properties relevant to the diagnosis and treatment of various diseases. There have been many reports indicating that carbon nanomaterials (CNMs) can interact and perturb biomolecules such as proteins and amyloid structures. This review is an attempt to reflect the...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mohajeri M,Behnam B,Barreto GE,Sahebkar A

    更新日期:2019-05-01 00:00:00

  • Increased urinary coproporphyrin excretion observed in patients with differently staged Hodgkin's disease treated with chemotherapy.

    abstract::It has been reported that patients with Hodgkin's disease (HD) show altered porphyrin metabolism, and suggested that the cause is the neoplastic process itself. If this is true, disease progression should be associated with higher levels of porphyrin excretion. The aim of this study was to evaluate urinary coproporphy...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pinelli A,Mussini C,Buratti M,Parmiggiani-Venezia M,Trivulzio S

    更新日期:2005-03-01 00:00:00

  • Effect of sodium-glucose co-transporter 2 inhibitors on lipid profile: A systematic review and meta-analysis of 48 randomized controlled trials.

    abstract::Previous studies have suggested additional beneficial effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors including the lipid-lowering effect; however, results on lipid profile are controversial. Thus, this meta-analysis aimed to determine the effect of SGLT2 inhibitors treatment on lipid levels in patients ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sánchez-García A,Simental-Mendía M,Millán-Alanís JM,Simental-Mendía LE

    更新日期:2020-10-01 00:00:00

  • Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression.

    abstract::The suppression of the abnormal systemic immune response constitutes a primary strategy for treatment of rheumatoid arthritis (RA); toward this end, the identification of natural compounds with immunosuppressive activity represents a promising strategy for RA drug discovery. Cinnamtannin D1 (CTD-1), a polyphenolic com...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Shi C,Zhang H,Wang X,Jin B,Jia Q,Li Y,Yang Y

    更新日期:2020-01-01 00:00:00

  • Thiamin status in furosemide-treated rats.

    abstract::Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg(-1)day(-1)for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ali BH,Al-Qarawi AA

    更新日期:2000-07-01 00:00:00

  • Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo.

    abstract::Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an onco-embryonic antigen presented on chronic lymphocytic leukemia (CLL), but not on normal adult tissues, which promotes CLL-cell survival. Here, ROR1 was identified as a new client of Heat Shock Protein 90 (HSP90) via a mass spectrometry-based screen for ROR...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Liu Z,Liu J,Zhang T,Shi M,Chen X,Chen Y,Yu J

    更新日期:2020-01-01 00:00:00

  • Dosing ribavirin in hepatitis E-infected solid organ transplant recipients.

    abstract::Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries. In the majority of cases, HEV causes a self-limiting hepatitis. GT3 and GT4 can be responsib...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: De Winter BCM,Hesselink DA,Kamar N

    更新日期:2018-04-01 00:00:00


    abstract:BACKGROUND:Many flavonoids have various beneficial actions like anti-inflammatory, anti-carcinogenic properties and many other clinical conditions. Astilbin is one such flavanoid compound having many physiological as well as pharmacological actions. PURPOSE:To summarize the important findings from the research conduct...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sharma A,Gupta S,Chauhan S,Nair A,Sharma P

    更新日期:2020-08-01 00:00:00