Abstract：
:Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CM and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections of CM in 450 and 900 mg kg(-1) doses resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. CM administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect of CM in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure CM.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Hunter KW Jr,Gault RA,Stehouwer JS,Tam-Chang SWdoi
10.1016/s1043-6618(02)00239-6keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
43-7issue
1eissn
1043-6618issn
1096-1186pii
S1043661802002396journal_volume
47pub_type
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