Cytochrome P450 epoxygenases as EDHF synthase(s).

Abstract:

:The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is not constitutive but is determined by a number of physical (fluid shear stress and cyclic stretch) and pharmacological stimuli which also affect responses attributed to an endothelium-derived hyperpolarizing factor (EDHF). This review summarizes the role played by EETs, and the enzymes that generate and metabolize them, in EDHF-mediated responses.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Fleming I

doi

10.1016/j.phrs.2003.11.016

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

525-33

issue

6

eissn

1043-6618

issn

1096-1186

pii

S1043661803004079

journal_volume

49

pub_type

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