Cytochrome P450 epoxygenases as EDHF synthase(s).


:The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is not constitutive but is determined by a number of physical (fluid shear stress and cyclic stretch) and pharmacological stimuli which also affect responses attributed to an endothelium-derived hyperpolarizing factor (EDHF). This review summarizes the role played by EETs, and the enzymes that generate and metabolize them, in EDHF-mediated responses.


Pharmacol Res


Pharmacological research


Fleming I





Has Abstract


2004-06-01 00:00:00














  • ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis.

    abstract::The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart and kidney homeostasis, but also plays an important role in the pathophysiology of heart and kidney diseases. Recently, new components of the RAS have been discovered, including angiotensin converting enzyme 2 (ACE2), Angiotensin(Ang)-(1-...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Simões E Silva AC,Teixeira MM

    更新日期:2016-05-01 00:00:00

  • Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions.

    abstract::The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Jeong HJ,Yi JM,Hong SH,Kong JY,Kim KS,Won JH,Cho KH,Shin TY,Kim HS,Kim HM

    更新日期:2002-11-01 00:00:00

  • Postmenopausal exogenous hormone therapy and Melanoma risk in women: A systematic review and time-response meta-analysis.

    abstract::A favourable option to management symptoms during menopausal transition is menopausal hormone therapy (MHT) but relation among MHT and risk of melanoma is controversial. This study aims to identify, analyse and present the evidence surrounding post-menopausal exogenous hormone therapy and the risk for melanoma in wome...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Tang X,Zhang H,Cui Y,Wang L,Wang Z,Zhang Y,Huo J,Cai J,Rinaldi G,Bhagavathula AS,Xiaopeng Y

    更新日期:2020-10-01 00:00:00

  • Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.

    abstract::Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. However resistance to anti-BRAF therapy usually develops within a few months and conseque...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Oliveira ÉA,Lima DS,Cardozo LE,Souza GF,de Souza N,Alves-Fernandes DK,Faião-Flores F,Quincoces JAP,Barros SBM,Nakaya HI,Monteiro G,Maria-Engler SS

    更新日期:2017-11-01 00:00:00

  • Strengths, weaknesses and future challenges of biosimilars' development. An opinion on how to improve the knowledge and use of biosimilars in clinical practice.

    abstract::Biosimilars started receiving the marketing authorization by European Medicine Agency since 2006. The development of biosimilars follows a well-defined step-wise approach, the so-called comparability exercise, which aims to compare non-clinical (mainly quality features and biological activity) and clinical (efficacy a...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Scavone C,Rafaniello C,Berrino L,Rossi F,Capuano A

    更新日期:2017-12-01 00:00:00

  • Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader.

    abstract::Breast cancer, the most prevalent cancer in women, remains the second in the list of cancer mortality, the majority of these fatalities resulted from estrogen receptor alpha (ERα) positive disease. ERα is well known for its function on breast cancer initiation and development and has become the most successful biomark...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao Y,Zhao C,Lu J,Wu J,Li C,Hu Z,Tian W,Yang L,Xiang J,Zhou H,Deng Z,Huang J,Hong K

    更新日期:2019-08-01 00:00:00

  • Circadian clock: Time for novel anticancer strategies?

    abstract::Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi B

    更新日期:2015-10-01 00:00:00

  • Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions.

    abstract::Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of pulmonary function, rapidly leading to death. While its clinical role as an anticancer agent is limited, its use in experimental settings is...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Della Latta V,Cecchettini A,Del Ry S,Morales MA

    更新日期:2015-07-01 00:00:00

  • Cholinergic responses of seminal vesicles isolated from rats exposed perinatally to hydrocortisone.

    abstract::This study was performed in order to investigate the cholinomimetic response of seminal vesicles isolated from rats treated with hydrocortisone acetate during perinatal life. At the adult phase, the body weight and the wet weight of the seminal vesicle of these animals were unchanged. However, these male rats exhibite...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pereira OC,Yasuhara F,Arena AC

    更新日期:2003-07-01 00:00:00

  • Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.

    abstract::Baroreflex plays a crucial role in regulation of arterial blood pressure (BP). Recently, Piezo1 and Piezo2, the mechanically-activated (MA) ion channels, have been identified as baroreceptors. However, the underlying molecular mechanism for regulating these baroreceptors in hypertension remains unknown. In this study,...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Huo L,Gao Y,Zhang D,Wang S,Han Y,Men H,Yang Z,Qin X,Wang R,Kong D,Bai H,Zhang H,Zhang W,Jia Z

    更新日期:2020-12-19 00:00:00

  • Study of the evolution of blood and striatal levels of methyldopa: a microdialysis study in sinaortic denervated rats.

    abstract::Pharmacokinetic of methyldopa (50 mg kg(-1)i.p.) was studied in anesthetized sham operated and sinoaortic denervated (SAD) rats by using the microdialysis technique. Vascular shunt probe was inserted into the carotid artery and concentric probe was placed in the striatum. Levels of methyldopa were measured by HPLC-EC....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Opezzo JA,Höcht C,Taira CA,Bramuglia GF

    更新日期:2000-04-01 00:00:00

  • Long noncoding RNA AK039312 and AK079370 inhibits bone formation via miR-199b-5p.

    abstract::Osteoporosis caused by aging and menopause had become an emerging threat to human health. The reduction of osteoblast differentiation has been considered to be an essential cause of osteoporosis. Osteoblast differentiation could be regulated by LncRNAs, and increasing evidences have proved that LncRNAs may be adopted ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yin C,Tian Y,Yu Y,Li D,Miao Z,Su P,Zhao Y,Wang X,Pei J,Zhang K,Qian A

    更新日期:2021-01-01 00:00:00

  • Effect of sodium-glucose co-transporter 2 inhibitors on lipid profile: A systematic review and meta-analysis of 48 randomized controlled trials.

    abstract::Previous studies have suggested additional beneficial effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors including the lipid-lowering effect; however, results on lipid profile are controversial. Thus, this meta-analysis aimed to determine the effect of SGLT2 inhibitors treatment on lipid levels in patients ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sánchez-García A,Simental-Mendía M,Millán-Alanís JM,Simental-Mendía LE

    更新日期:2020-10-01 00:00:00

  • Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

    abstract::This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent wi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Koutsoviti-Papadopoulou M,Nikolaidis E,Kounenis G

    更新日期:2001-09-01 00:00:00

  • Gastrointestinal effects of single and repeated doses of ferrous sulphate in rats.

    abstract::The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faec...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

    更新日期:1993-01-01 00:00:00

  • Investigation of cancer drug resistance mechanisms by phosphoproteomics.

    abstract::Cancer cell mutations can be identified by genomic and transcriptomic techniques. However, they are not sufficient to understand the full complexity of cancer heterogeneity. Analyses of proteins expressed in cancers and their modification profiles show how these mutations could be translated at the functional level. P...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Boulos JC,Yousof Idres MR,Efferth T

    更新日期:2020-10-01 00:00:00

  • Prochlorperazine induces central antinociception mediated by the muscarinic system.

    abstract::The antinociceptive effect of the D(2) antagonist prochlorperazine was examined in the mouse hot-plate and abdominal constriction tests. Prochlorperazine (1-2 mg kg(-1) s.c./i.p.) produced an increase of the pain threshold in the mouse hot-plate test. The antinociception produced by prochlorperazine was prevented by t...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ghelardini C,Galeotti N,Uslenghi C,Grazioli I,Bartolini A

    更新日期:2004-09-01 00:00:00

  • Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice.

    abstract::Our goal was to establish the requirement of β3 adrenoceptor (β3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and β3Adr knockout (KO) male mice fed with a standard diet or a high-fat diet (HFD/16 weeks) treated or not with GT (0.5 g/kg of body weig...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sousa-Filho CPB,Faria HOF,Esposito JC,Melo A,Ribeiro MO,Otton R

    更新日期:2020-09-01 00:00:00

  • The use of ranolazine in non-anginal cardiovascular disorders: A review of current data and ongoing randomized clinical trials.

    abstract::Ranolazine has characteristic properties of a selective inhibitor of the inward sodium current. It is primarily indicated as an anti-anginal agent in patients with coronary artery disease and chronic stable angina. Recently, ranolazine has been noted to possibly impart beneficial effects in various other cardiac condi...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mihos CG,Krishna RK,Kherada N,Larrauri-Reyes M,Tolentino A,Santana O

    更新日期:2016-01-01 00:00:00

  • Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety.

    abstract::Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

    更新日期:2017-08-01 00:00:00

  • Pyridoxol L,2-pyrrolidon-5 carboxylate prevents active fibroplasia in CCl4-treated rats.

    abstract::In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

    更新日期:1992-01-01 00:00:00

  • Clinical effectiveness of zinc supplementation on the biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Oxidative stress plays an important role in the occurrence of chronic diseases. Zinc supplementation is also known to be an antioxidant agent. While, there is no review on the effects of zinc supplementation on oxidative stress, this study aimed to systematically summarize randomized clinical trials (RCTs) w...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mousavi SM,Hajishafiee M,Clark CCT,Borges do Nascimento IJ,Milajerdi A,Amini MR,Esmaillzadeh A

    更新日期:2020-11-01 00:00:00

  • Exogenous insulin-like growth factor (IGF)-1 improves the impaired healing of gastric mucosal lesions in diabetic rats.

    abstract:BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Korolkiewicz RP,Tashima K,Fujita A,Kato S,Takeuchi K

    更新日期:2000-02-01 00:00:00

  • Dosing ribavirin in hepatitis E-infected solid organ transplant recipients.

    abstract::Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries. In the majority of cases, HEV causes a self-limiting hepatitis. GT3 and GT4 can be responsib...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: De Winter BCM,Hesselink DA,Kamar N

    更新日期:2018-04-01 00:00:00

  • Boosting immunity to treat parasitic infections: Asaia bacteria expressing a protein from Wolbachia determine M1 macrophage activation and killing of Leishmania protozoans.

    abstract::Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

    更新日期:2020-11-01 00:00:00

  • Pediatric drug development in China: Reforms and challenges.

    abstract::In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study,we introduced the current ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Wu W,Tang Z,Chen J,Gao Y

    更新日期:2019-10-01 00:00:00

  • Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

    abstract::Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhu Y,Zhu C,Yang H,Deng J,Fan D

    更新日期:2020-05-01 00:00:00

  • Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B.

    abstract::Monoamine oxidases (MAO) are mitochondrial enzymes that catalyze the oxidation of monoamines in multiple tissues, including the brain. Elevated MAO activity has long been implicated in the etiology of depression, anxiety, and neurodegenerative disease, fuelling the search for inhibitors in the prevention and treatment...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Dreiseitel A,Korte G,Schreier P,Oehme A,Locher S,Domani M,Hajak G,Sand PG

    更新日期:2009-05-01 00:00:00

  • Influence of albendazole on the disposition kinetics and milk antimicrobial equivalent activity of enrofloxacin in lactating goats.

    abstract::The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Abo El Sooud K

    更新日期:2003-10-01 00:00:00

  • Extensive characterization of the human DDAH1 transgenic mice.

    abstract:PURPOSE OF THE RESEARCH:Overexpression of the human dimethylarginine dimethylaminohydrolase type 1 (hDDAH1) gene was reported to have beneficial cardiovascular effects in mice. To date, it is unclear whether these effects are related to enhanced metabolic clearance of asymmetric dimethylarginine (ADMA) and l-N(G)-mono-...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Schwedhelm E,von Leitner EC,Atzler D,Schmitz C,Jacobi J,Meinertz T,Münzel T,Baldus S,Cooke JP,Böger RH,Maas R,Sydow K

    更新日期:2009-12-01 00:00:00