Abstract:
:In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335 inhibited the passive cutaneous anaphylaxis (PCA) reactions in rats in a dose-dependent manner (0.5-10 mg kg-1 p.o.) by 47-90%. There was a 70-87% protection of mast cell degranulation induced by compound 48/80 with peptide 94-335 at 0.5-1.5 mg kg-1 p.o. in rats. This peptide also inhibited antigen- induced contraction in sensitised guinea pig ileum. There was 18 and 72% protection to bronchoconstriction induced by histamine and egg albumin, respectively, in an aerosol test in guinea pigs. These effects of compound 94-335 were comparable with that of the clinically-used antiallergic drug disodium cromoglycate (DSCG). The results suggest that peptide 94-335 possesses potent antiallergic activity.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Singh R,Nath A,Gupta PP,Shulka M,Khare SK,Kundu Bdoi
10.1006/phrs.1998.0302subject
Has Abstractpub_date
1998-05-01 00:00:00pages
353-6issue
5eissn
1043-6618issn
1096-1186pii
S1043-6618(98)90302-4journal_volume
37pub_type
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