Biochemical and hematological side effects of clofazimine in leprosy patients.


:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses currently employed in therapy have not been sufficiently documented. We therefore investigated the correlation between CFZ plasma concentration and biochemical (transaminases, bilirubins, alkaline phosphatase, gamma-glutamyltransferase, amylase, urea, creatinine, and potassium plasma levels) as well as hematological changes blood and reticulocyte counts, osmotic fragility, detection of Heinz bodies and methemoglobinemia (MHM), following in two regimes of treatment: CFZ as a single drug and CFZ as part of multidrug (MDT) therapy, in combination with dapsone and rifampicin. MHM and hemolytic anemia were detected in the MDT group only. Eosinophilia was found in patients of either group. Determination of hepatic, pancreatic and renal biochemical parameters showed rare, occasional changes of apparently no clinical significance. We conclude that CFZ is a generally well tolerated and safe drug when given as a daily dose of 50mg, which is currently used in leprosy patients.


Pharmacol Res


Pharmacological research


Costa Queiroz RH,de Souza AM,Sampaio SV,Melchior E Jr





Has Abstract


2002-08-01 00:00:00














  • New perspectives in melatonin uses.

    abstract::This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potent...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Carpentieri A,Díaz de Barboza G,Areco V,Peralta López M,Tolosa de Talamoni N

    更新日期:2012-04-01 00:00:00

  • The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder.

    abstract::Some bladder disorders, such as obstructive bladder and hyperactivity, may be caused partly by ischemia/reperfusion injury (I/R). The neuroprotective effects of estrogens were demonstrated in in vitro studies and a great interest in soy isoflavones (genistein and daidzein) as alternative to the synthetic estrogen rece...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Valeri A,Fiorenzani P,Rossi R,Aloisi AM,Valoti M,Pessina F

    更新日期:2012-10-01 00:00:00

  • Microalgae-derived oxylipins decrease inflammatory mediators by regulating the subcellular location of NFκB and PPAR-γ.

    abstract::Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ávila-Román J,Talero E,de Los Reyes C,García-Mauriño S,Motilva V

    更新日期:2018-02-01 00:00:00

  • Microarray analysis of vanillin-regulated gene expression profile in human hepatocarcinoma cells.

    abstract::Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

    更新日期:2007-12-01 00:00:00

  • Anticholinergic action of clonidine in rats with sinoaortic denervation.

    abstract::A study was carried out relating to the anticholinergic action of clonidine on the cardiovascular responses to i.c.v. injection of neostigmine, a quaternary anticholinesterase, in conscious sham-operated animals and rats with sinoaortic denervation, 7 days after the corresponding operation. Neostigmine (0.1-1 microgra...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Taira CA

    更新日期:1998-04-01 00:00:00

  • Palmitoylation in Alzheimer's disease and other neurodegenerative diseases.

    abstract::Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulati...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Cho E,Park M

    更新日期:2016-09-01 00:00:00

  • Weight control and prevention of metabolic syndrome by green tea.

    abstract::Green tea (Camellia sinensis, Theaceace) is the second most popular beverage in the world and has been extensively studied for its putative disease preventive effects. Green tea is characterized by the presence of a high concentrations of polyphenolic compounds known as catechins, with (-)-epigallocatechin-3-gallate (...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sae-tan S,Grove KA,Lambert JD

    更新日期:2011-08-01 00:00:00

  • Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives.

    abstract::Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gambardella A,Labate A,Cifelli P,Ruffolo G,Mumoli L,Aronica E,Palma E

    更新日期:2016-11-01 00:00:00

  • Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets.

    abstract::A pharmacokinetic study of the metabolic profile of resveratrol has been performed in healthy men after moderate red wine (RW) consumption. The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ing...

    journal_title:Pharmacological research

    pub_type: 杂志文章,随机对照试验


    authors: Rotches-Ribalta M,Andres-Lacueva C,Estruch R,Escribano E,Urpi-Sarda M

    更新日期:2012-11-01 00:00:00

  • ApoA-IMilano phospholipid complex (ETC-216) infusion in human volunteers. Insights into the phenotypic characteristics of ApoA-IMilano carriers.

    abstract::Epidemiological studies support an inverse correlation between HDL-C and cardiovascular disease. However, low HDL-C levels do not always segregate with premature disease. These include, LCAT deficiency and the apolipoproteinA-IMilano (AIM) variant. AIM has a cysteine for arginine at position 173 in the otherwise cyste...

    journal_title:Pharmacological research

    pub_type: 杂志文章,随机对照试验


    authors: Bisgaier CL,Ackermann R,Rea T,Rodrigueza WV,Hartman D

    更新日期:2016-09-01 00:00:00

  • Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease.

    abstract::Accumulation of amyloid-β peptides (Aβ) within brain is a major pathogenic hallmark of Alzheimer's disease (AD). Emerging evidence suggests that autophagy, an important intracellular catabolic process, is involved in Aβ clearance. Here, we investigated whether temsirolimus, a newly developed compound approved by Food ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Jiang T,Yu JT,Zhu XC,Tan MS,Wang HF,Cao L,Zhang QQ,Shi JQ,Gao L,Qin H,Zhang YD,Tan L

    更新日期:2014-03-01 00:00:00

  • Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

    abstract::This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent wi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Koutsoviti-Papadopoulou M,Nikolaidis E,Kounenis G

    更新日期:2001-09-01 00:00:00

  • Hydralazine improves ischemia-induced neovasculogenesis via xanthine-oxidase inhibition in chronic renal insufficiency.

    abstract::Oxidative stress is related to the progression of renal diseases and modulation of oxidative stress can lead to a reduction in vascular events in patients with chronic renal insufficiency (CRI). Indoxyl sulfate (IS) and xanthine oxidase (XO) are related to impaired neovasculogenesis in CRI. Hydralazine is suggested fo...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Chang TT,Chen JW

    更新日期:2020-01-01 00:00:00

  • More than just an enzyme: Dipeptidyl peptidase-4 (DPP-4) and its association with diabetic kidney remodelling.

    abstract:PURPOSE OF THE REVIEW:This review article discusses recent advances in the mechanism of dipeptidyl peptidase-4 (DPP-4) actions in renal diseases, especially diabetic kidney fibrosis, and summarizes anti-fibrotic functions of various DPP-4 inhibitors in diabetic nephropathy (DN). RECENT FINDINGS:DN is a common complica...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gupta S,Sen U

    更新日期:2019-09-01 00:00:00

  • Dual role of betel leaf extract on thyroid function in male mice.

    abstract::The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panda S,Kar A

    更新日期:1998-12-01 00:00:00

  • Endothelin-1 (ET-1) and vein graft failure and the therapeutic potential of ET-1 receptor antagonists.

    abstract::Despite the exploration of a large number of disparate drugs in animal models and clinical trials, no pharmacological intervention, with the exception of aggressive lipid lowering therapy has reduced late vein graft failure in man. The importance of devising more effective strategies is exemplified by the enormous eco...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Jeremy JY,Shukla N,Angelini GD,Wan S

    更新日期:2011-06-01 00:00:00

  • Pharmacokinetics of fructose-1,6-diphosphate after intraperitoneal and oral administration to adult rats.

    abstract::Exogenously administered fructose-1,6-diphosphate (FDP) has been studied for its ability to protect tissue during hypoxia or ischemia. Recently, a clear effect of FDP on the central nervous system has raised the question whether FDP can get into the brain. FDP levels were measured in blood, brain, liver, kidney, muscl...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xu K,Stringer JL

    更新日期:2008-03-01 00:00:00

  • Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.

    abstract::Metastatic and primary bone cancers are usually accompanied by severe pain that is difficult to manage. In light of the adverse side effects of opioids, manipulation of the endocannabinoid system may provide an effective alternative for the treatment of cancer pain. The present study determined that a local, periphera...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Khasabova IA,Chandiramani A,Harding-Rose C,Simone DA,Seybold VS

    更新日期:2011-07-01 00:00:00

  • Brain microRNAs dysregulation: Implication for missplicing and abnormal post-translational modifications of tau protein in Alzheimer's disease and related tauopathies.

    abstract::MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression by targeting specific mRNAs for degradation or translation repression. Changes in miRNAs expression profiles have been reported in several neurodegenerative disorders such as Alzheimer's disease (AD) and related tauopathies...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Bazrgar M,Khodabakhsh P,Mohagheghi F,Prudencio M,Ahmadiani A

    更新日期:2020-05-01 00:00:00

  • Chasing c-Kit through the heart: Taking a broader view.

    abstract::Stem cell mediated cardiac repair is an exciting and controversial area of cardiovascular research that holds the potential to produce novel, revolutionary therapies for the treatment of heart disease. Extensive investigation to define cell types contributing to cardiac formation, homeostasis and regeneration has prod...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gude NA,Sussman MA

    更新日期:2018-01-01 00:00:00

  • The acute alterations in biochemistry, morphology, and contractility of rat-isolated terminal ileum via increased intra-abdominal pressure.

    abstract:AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Unsal MA,Imamoglu M,Kadioglu M,Aydin S,Ulku C,Kesim M,Alver A,Kalyoncu NI,Yaris E,Bozkaya H

    更新日期:2006-02-01 00:00:00

  • Stereoselective biotransformation of cicletanine in cultured rat and human hepatocytes.

    abstract::Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

    更新日期:2000-07-01 00:00:00

  • The development of medicines for children. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

    abstract::The lack of availability of appropriate medicines for children is an extensive and well known problem. As a consequence off label or unlicensed administration of medicinal products in every day paediatric practice is frequent. A variety of obstacles hinder the development of paediatric indications for drugs primarily ...

    journal_title:Pharmacological research

    pub_type: 社论,评审


    authors: Rocchi F,Tomasi P

    更新日期:2011-09-01 00:00:00

  • Anti-diabetic effects of Gymnema yunnanense extract.

    abstract::In this study, we evaluated anti-hyperglycemic effect and body weight reduction activity of Gymnema yunnanense extract in obese ob/ob and diabetic db/db mice. Animals received daily intraperitoneal injections of the extract 100 mg/kg for 12 days. On Day 5, the extract-treated ob/ob mice had significantly lower fasting...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xie JT,Wang A,Mehendale S,Wu J,Aung HH,Dey L,Qiu S,Yuan CS

    更新日期:2003-04-01 00:00:00

  • Antibody modulation: Limiting the efficacy of therapeutic antibodies.

    abstract::Monoclonal antibodies (mAb) have revolutionised the way in which we treat disease. From cancer to autoimmunity, antibody therapy has been responsible for some of the most impressive clinical responses observed in the last 2 decades. A key component of this success has been their generally low levels of toxicity, and u...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Vaughan AT,Cragg MS,Beers SA

    更新日期:2015-09-01 00:00:00

  • Protein kinase C and alcohol addiction.

    abstract::Alcohol abuse and addiction are serious global health problems. Tackling these disorders requires an understanding of how ethanol produces its effects. Early cell culture studies implicated the protein kinase C (PKC) family of serine-threonine kinases in mediating both acute and chronic responses to ethanol exposure. ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Newton PM,Ron D

    更新日期:2007-06-01 00:00:00

  • Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized by gradual loss of cognitive functions. In the last decade, numerous research works were undertaken to investigate the pathogenesis of A...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sadhukhan P,Saha S,Dutta S,Mahalanobish S,Sil PC

    更新日期:2018-03-01 00:00:00

  • Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.

    abstract::Cannabinoids have emerged as promising neuroprotective agents due to their capability to activate specific targets, which are involved in the control of neuronal homeostasis and survival. Specifically, those ligands that selectively target and activate the CB2 receptor may be useful for their anti-inflammatory and neu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gómez-Cañas M,Morales P,García-Toscano L,Navarrete C,Muñoz E,Jagerovic N,Fernández-Ruiz J,García-Arencibia M,Pazos MR

    更新日期:2016-08-01 00:00:00

  • Funny channels in the control of cardiac rhythm and mode of action of selective blockers.

    abstract::"Funny" (f) channels underlie the cardiac "pacemaker"I(f) current, originally described as an inward current activated on hyperpolarization to the diastolic range of voltages in sino-atrial node myocytes [Brown, HF, DiFrancesco, D, Noble, SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236]. The invo...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: DiFrancesco D

    更新日期:2006-05-01 00:00:00

  • Interactions of gut microbiota with functional food components and nutraceuticals.

    abstract::The human gut is populated by an array of bacterial species, which develop important metabolic and immune functions, with a marked effect on the nutritional and health status of the host. Dietary component also play beneficial roles beyond basic nutrition, leading to the development of the functional food concept and ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Laparra JM,Sanz Y

    更新日期:2010-03-01 00:00:00