Biochemical and hematological side effects of clofazimine in leprosy patients.

Abstract:

:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses currently employed in therapy have not been sufficiently documented. We therefore investigated the correlation between CFZ plasma concentration and biochemical (transaminases, bilirubins, alkaline phosphatase, gamma-glutamyltransferase, amylase, urea, creatinine, and potassium plasma levels) as well as hematological changes blood and reticulocyte counts, osmotic fragility, detection of Heinz bodies and methemoglobinemia (MHM), following in two regimes of treatment: CFZ as a single drug and CFZ as part of multidrug (MDT) therapy, in combination with dapsone and rifampicin. MHM and hemolytic anemia were detected in the MDT group only. Eosinophilia was found in patients of either group. Determination of hepatic, pancreatic and renal biochemical parameters showed rare, occasional changes of apparently no clinical significance. We conclude that CFZ is a generally well tolerated and safe drug when given as a daily dose of 50mg, which is currently used in leprosy patients.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Costa Queiroz RH,de Souza AM,Sampaio SV,Melchior E Jr

doi

10.1016/s1043-6618(02)00086-5

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

191-4

issue

2

eissn

1043-6618

issn

1096-1186

pii

S1043661802000865

journal_volume

46

pub_type

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