Abstract：
:Asthma and COPD make up the majority of obstructive airways diseases (OADs), which affects ∼11 % of the population. The main drugs used to treat OADs have not changed in the past five decades, with advancements mainly comprising variations on existing treatments. The recent biologics are beneficial to only specific subsets of patients. Part of this may lie in our inability to adequately characterise the tremendous heterogeneity in every aspect of OAD. The field is currently moving towards the concept of personalised medicine, based on a focus on treatable traits that are objective, measurable and modifiable. We propose extending this concept via the use of emerging clinical tools for comprehensive physiological phenotyping. We describe, based on published data, the evidence for the use of functional imaging, gas washout techniques and oscillometry, as well as potential future applications, to more comprehensively assess and predict treatment response in OADs. In this way, we hope to demonstrate how physiological phenotyping tools will improve the way in which drugs are prescribed, but most importantly, will facilitate development of new drugs for OADs.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Chapman DG,King GG,Robinson PD,Farah CS,Thamrin Cdoi
10.1016/j.phrs.2020.105029subject
Has Abstractpub_date
2020-09-01 00:00:00pages
105029eissn
1043-6618issn
1096-1186pii
S1043-6618(20)31337-2journal_volume
159pub_type
杂志文章abstract：:A major focus of contemporary drug screening strategies is the identification of novel anticancer compounds, which often results in underutilization of resources. Current drug evaluation involves in vivo tumor (xenograft) regression as proof-of-principle for cytotoxicity (POC). However, this end-point lacks any assess...
journal_title：Pharmacological research
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journal_title：Pharmacological research
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更新日期：2015-05-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2002-02-01 00:00:00
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更新日期：2010-02-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2004-11-01 00:00:00
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更新日期：2016-08-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2016-11-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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更新日期：2010-11-01 00:00:00
abstract：:The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...
journal_title：Pharmacological research
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更新日期：2003-10-01 00:00:00
