Relationship between constitutive nitric oxide synthase activity and mucus level in the gastric mucosa of rats with stress.

abstract：:We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition me...

journal_title：Pharmacological research

authors： Winnicka MM,Braszko JJ,Wiśniewski K

更新日期：1997-11-01 00:00:00

abstract：:QiShenYiQi Pills (QSYQ) is a compound Chinese medicine widely used in China for treatment of cardiovascular disease. However, limited data are available regarding the anti-fibrotic role of QSYQ after ischemia/reperfusion (I/R) injury. This study aimed to investigate the effect of post-treatment with QSYQ on myocardial...

journal_title：Pharmacological research

authors： Zheng QN,Wei XH,Pan CS,Li Q,Liu YY,Fan JY,Han JY

更新日期：2019-08-01 00:00:00

abstract：:The study was undertaken using selected pharmacodynamic parameters to describe the effects of porcine galanin(1-29)-NH2; porcine galanin fragments; galantide; porcine galanin(1-14)-[alpha-aminobutyric acid8]scyliorhinin-I and the analogues of the latter peptides on rat isolated gastric fundus muscle. All tested peptid...

journal_title：Pharmacological research

authors： Korolkiewicz R,Sliwiński W,Rekowski P,Halama-Borowiec A,Mucha P,Szczurowicz A,Korolkiewicz KZ

更新日期：1997-01-01 00:00:00

abstract：:Progressive neuronal death is the key pathogenic event leading to clinical symptoms in neurodegenerative disorders (NDDs). Neuroprotective treatments are virtually unavailable, partly because of the marked internal heterogeneity of the mechanisms underlying pathology. Targeted neuroprotection would require deep mechan...

journal_title：Pharmacological research

authors： Masi A,Narducci R,Mannaioni G

更新日期：2019-09-01 00:00:00

abstract：:This paper discusses the discovery of ligands for orphan receptors and the identification of the natural endogenous ligands for those receptors in physiology. The central thesis is that orphan seven transmembrane receptors (7TMRs) are allosteric conduits of chemical information exchange from extracellular ligands to i...

journal_title：Pharmacological research

authors： Kenakin TP

更新日期：2016-12-01 00:00:00

abstract：:The rationale underlying therapeutic strategies designed to inhibit the action of endogenous sex hormones in malignant breast cells is provided by the demonstration of their involvement in supporting the development and growth of breast carcinoma. The surgical removal of steroid-secreting glands, in order to reduce th...

journal_title：Pharmacological research

authors： de Cupis A,Schettini G,Favoni RE

更新日期：1999-05-01 00:00:00

abstract：:The mechanisms involved in enhanced cough induced by central and inhaled NGF in guinea pigs were investigated. Cough and airway function were assessed by plethysmography following inhaled or intracerebroventricular (i.c.v.) NGF treatment. Expression of TrkA and/or TRPV1 was determined in bronchi and/or brainstem by re...

journal_title：Pharmacological research

authors： El-Hashim AZ,Jaffal SM,Al-Rashidi FT,Luqmani YA,Akhtar S

更新日期：2013-08-01 00:00:00

abstract：:The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decreas...

journal_title：Pharmacological research

authors： Sumathi R,Jayanthi S,Kalpanadevi V,Varalakshmi P

更新日期：1993-05-01 00:00:00

abstract：:Gamma-vinyl GABA (vigabatrin; VGB), an irreversible inhibitor of GABA-transaminase, was evaluated for its effect on the contractile responses to PGE(2) or its precursor arachidonic acid (AA) in guinea pig ileum (GPI) and non-pregnant rat uterus. Rationale behind this study was the rise in gamma-aminobutyric acid (GABA...

journal_title：Pharmacological research

authors： Raza M,Al-Shabanah OA

更新日期：2003-06-01 00:00:00

abstract：:Neuroinflammation plays an important role in the progression of various neurodegenerative diseases. In this study, we investigated the anti-inflammatory effects of lonchocarpine, a natural compound isolated from Abrus precatorius, under in vitro and in vivo neuroinflammatory conditions induced by challenge with lipopo...

journal_title：Pharmacological research

authors： Jeong YH,Park JS,Kim DH,Kang JL,Kim HS

更新日期：2017-05-01 00:00:00

abstract：:We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa multiple ascending dose study (0.25, 0.75, 2.0, and 6.0 mg/kg/day) enrolled 48 boys with Duchenne muscular dystrophy (4 to <7 years), with ...

journal_title：Pharmacological research

authors： Conklin LS,Damsker JM,Hoffman EP,Jusko WJ,Mavroudis PD,Schwartz BD,Mengle-Gaw LJ,Smith EC,Mah JK,Guglieri M,Nevo Y,Kuntz N,McDonald CM,Tulinius M,Ryan MM,Webster R,Castro D,Finkel RS,Smith AL,Morgenroth LP,Arrieta

更新日期：2018-10-01 00:00:00

abstract：:Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

journal_title：Pharmacological research

authors： Mougenot N,Médiani O,Lechat P

更新日期：2005-04-01 00:00:00

abstract：:Endocannabinoids exhibit vasodilatory properties and reduce blood pressure in vivo. However, the influence and mechanism of action of the prominent endocannabinoid, anandamide (AEA), in pulmonary arteries are not known. The present study determined the vascular response to AEA in isolated rat pulmonary arteries. AEA r...

journal_title：Pharmacological research

authors： Baranowska-Kuczko M,MacLean MR,Kozłowska H,Malinowska B

更新日期：2012-09-01 00:00:00

abstract：:Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

journal_title：Pharmacological research

authors： Epstein AN

更新日期：1992-02-01 00:00:00

abstract：:Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the con...

journal_title：Pharmacological research

authors： de Leon J

更新日期：2009-02-01 00:00:00

abstract：:The Janus kinase (JAK) family of non-receptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (tyrosine kinase-2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that regulates the adjacent protein kinase domain (JH1). JAK1/2 and TYK2 are ubiquitously expressed whereas JAK3 is...

journal_title：Pharmacological research

authors： Roskoski R Jr

更新日期：2016-09-01 00:00:00

abstract：:DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

journal_title：Pharmacological research

authors： Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

更新日期：2010-02-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is being sold as a panacea that has the capability of reducing or eliminating cancer, preventing heart disease, improving immune function, and altering body composition to treat obesity or build lean body mass. Unfortunately, there has been very little published human research on CLA. Th...

journal_title：Pharmacological research

authors： Whigham LD,Cook ME,Atkinson RL

更新日期：2000-12-01 00:00:00

abstract：:This study was performed in order to investigate the cholinomimetic response of seminal vesicles isolated from rats treated with hydrocortisone acetate during perinatal life. At the adult phase, the body weight and the wet weight of the seminal vesicle of these animals were unchanged. However, these male rats exhibite...

journal_title：Pharmacological research

authors： Pereira OC,Yasuhara F,Arena AC

更新日期：2003-07-01 00:00:00

abstract：:Although calcimimetics were developed to block parathyroid hormone synthesis, some reports suggest that they may also reduce blood pressure by unknown mechanisms. Calcimimetic-induced changes in the synthesis of endothelial vasoactive factors could be involved. Wistar rats were treated with the calcimimetic R-568, and...

journal_title：Pharmacological research

authors： Martínez-Miguel P,Medrano-Andrés D,Lopes-Martín V,Arribas-Gómez I,Rodríguez-Puyol M,Rodríguez-Puyol D,López-Ongil S

更新日期：2013-10-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of ...

journal_title：Pharmacological research

authors： Huber G,Schuster F,Raasch W

更新日期：2017-11-01 00:00:00

abstract：:A pharmacokinetic study of the metabolic profile of resveratrol has been performed in healthy men after moderate red wine (RW) consumption. The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ing...

journal_title：Pharmacological research

authors： Rotches-Ribalta M,Andres-Lacueva C,Estruch R,Escribano E,Urpi-Sarda M

更新日期：2012-11-01 00:00:00

abstract：:Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patient...

journal_title：Pharmacological research

authors： Ahaneku JE,Sakata K,Urano T,Takada Y,Takada A

更新日期：2000-01-01 00:00:00

abstract：:Kidney injury is one of the main complications of obstructive jaundice (OJ) and its pathogenesis has not been clarified. As an independent risk factor for OJ associated with significant morbidity and mortality, it can be mainly divided into two types of morphological injury and functional injury. We called these dysfu...

journal_title：Pharmacological research

authors： Liu J,Qu J,Chen H,Ge P,Jiang Y,Xu C,Chen H,Shang D,Zhang G

更新日期：2021-01-01 00:00:00

abstract：:The present study examines the effect of benzyl isothiocyanate (BITC) on uterine contraction in vitro. BITC (10-320 microM) caused irreversible, concentration-dependent inhibition of the spontaneous, prostaglandin F(2alpha) (PGF(2alpha)) and oxytocin-induced force of gravid and non-gravid rat uterine contractions in c...

journal_title：Pharmacological research

authors： Adebiyi A,Adaikan PG,Prasad RN

更新日期：2004-05-01 00:00:00

abstract：:Cytophotometric measurement of the effect of praziquantel (500 mg/kg for 2 days) versus hycanthone (60 mg/kg for 3 days) on hepatocyte nuclear deoxyribonucleic acid (DNA) content was evaluated in Schistosoma mansoni infected mice. Drugs were given 8 weeks post-infection and repeated weekly for 4 weeks. DNA values of i...

journal_title：Pharmacological research

authors： Botros SS

更新日期：1990-03-01 00:00:00

abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

journal_title：Pharmacological research

authors： Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

更新日期：2000-01-01 00:00:00

abstract：:Sesquiterpene lactones (SL) are natural bioactive molecules indicated as potential scaffolds for anti-inflammatory and analgesic drug design. However, their anti-inflammatory applicability remains underestimated since the impact of SL on inflammatory nociception and tissue repair are overlooked. Thus, we used an integ...

journal_title：Pharmacological research

authors： Silva LP,Santos EC,Borges BA,Veloso MP,Chagas-Paula DA,Gonçalves RV,Novaes RD

更新日期：2020-11-16 00:00:00

abstract：:The endogenous gasotransmitter hydrogen sulphide (H2S) is an important regulator of the cardiovascular system, particularly of myocardial function. Moreover, H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury, and is considered an important mediator of "ischemic preconditioning...

journal_title：Pharmacological research

authors： Testai L,Marino A,Piano I,Brancaleone V,Tomita K,Di Cesare Mannelli L,Martelli A,Citi V,Breschi MC,Levi R,Gargini C,Bucci M,Cirino G,Ghelardini C,Calderone V

更新日期：2016-11-01 00:00:00

abstract：:Regulatory T cells (Tregs) modulate ongoing immune responses to prevent autoimmunity in healthy bodies and inhibit effective anti-tumor immunity responses in tumor patients, leading to tumor progression. The function of Tregs in tumor immunity suggests that elimination of Tregs in the host may enhance the anti-tumor i...

journal_title：Pharmacological research

authors： Wei T,Zhong W,Li Q

更新日期：2020-03-01 00:00:00