Relationship between constitutive nitric oxide synthase activity and mucus level in the gastric mucosa of rats with stress.


:A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and adherent mucus concentrations were enhanced with a further decrease in gastric mucosal cNOS activity by pretreatment with NG-monomethyl L-arginine, a non-selective NOS inhibitor, but were prevented with maintenance of the gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective inducible NO synthase inhibitor. In all WIR-stressed rats used in this study, gastric mucosal cNOS activity was well correlated with either gastric mucosal hexosamine or adherent mucus concentration (r=0.717 or 0.739, respectively). These results indicate that in the gastric mucosa of WIR-stressed rats, a decrease in cNOS activity is closely related to a decrease in mucus level due to impairment of its synthesis and secretion. (c) 1998 The Italian Pharmacological Society.


Pharmacol Res


Pharmacological research


Nishida K,Ohta Y,Ishiguro I




Has Abstract


1998-11-01 00:00:00














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    abstract::In recent clinical observation, the growth of endothelial tumors, such as hemangiomas of infancy, was repressed by the non-selective beta-adrenergic antagonist propranolol possibly through targeting of the vascular endothelial compartment. As human brain microvascular endothelial cells (HBMEC) play an essential role a...

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  • Antinociceptive and antiinflammatory activities of Artemisia copa extracts.

    abstract::The aqueous extract from aerial parts of Artemisia copa Phil. (Compositae), was evaluated for antinociceptive activity using writhing, formalin, and hot-plate tests in mice. A dose-related antinociceptive response was obtained in the writhing test at doses of 500 and 1000 mg/kg p.o. (percentage of inhibition 23.3 and ...

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  • Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system.

    abstract:AIM:Acute myocardial infarction and subsequent post-infarction heart failure are among the leading causes of mortality worldwide. The endocannabinoid system has emerged as an important modulator of cardiovascular disease, however the role of endocannabinoid metabolic enzymes in heart failure is still elusive. Herein, w...

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    authors: Martínez-Miguel P,Medrano-Andrés D,Lopes-Martín V,Arribas-Gómez I,Rodríguez-Puyol M,Rodríguez-Puyol D,López-Ongil S

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  • The effects of doxazosin on plasma lipid and lipoprotein levels in hypertensive patients.

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    pub_type: 临床试验,杂志文章


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    pub_type: 杂志文章


    authors: Rastogi L,Patnaik GK,Dikshit M

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    authors: Malfitano AM,Marasco G,Proto MC,Laezza C,Gazzerro P,Bifulco M

    更新日期:2014-10-01 00:00:00

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    abstract::Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

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    pub_type: 杂志文章


    authors: Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

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    pub_type: 杂志文章,meta分析,评审


    authors: Dinca M,Serban MC,Sahebkar A,Mikhailidis DP,Toth PP,Martin SS,Blaha MJ,Blüher M,Gurban C,Penson P,Michos ED,Hernandez AV,Jones SR,Banach M,for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

    更新日期:2016-05-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Lacal PM,Graziani G

    更新日期:2018-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

    更新日期:1993-01-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zheng P,Wang Q,Teng J,Chen J

    更新日期:2015-09-01 00:00:00