Abstract:
:The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decrease in catalase activity and glutathione (GSH) level, are the salient features observed in tissues of hyperoxaluric rats. Free radical toxicity in the glycollate fed rats is effectively counteracted by lipoic acid administration. Lipoic acid administration brought about a significant decrease in peroxidative levels with an increase in catalase activity and glutathione level. These observations highlight the antioxidant property of alpha-lipoic acid and its cytoprotective action against experimental hyperoxaluria.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Sumathi R,Jayanthi S,Kalpanadevi V,Varalakshmi Pdoi
10.1006/phrs.1993.1031subject
Has Abstractpub_date
1993-05-01 00:00:00pages
309-18issue
4eissn
1043-6618issn
1096-1186pii
S1043-6618(83)71031-5journal_volume
27pub_type
杂志文章abstract::Green tea (Camellia sinensis, Theaceace) is the second most popular beverage in the world and has been extensively studied for its putative disease preventive effects. Green tea is characterized by the presence of a high concentrations of polyphenolic compounds known as catechins, with (-)-epigallocatechin-3-gallate (...
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journal_title:Pharmacological research
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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