Effect of DL alpha-lipoic acid on tissue lipid peroxidation and antioxidant systems in normal and glycollate treated rats.


:The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decrease in catalase activity and glutathione (GSH) level, are the salient features observed in tissues of hyperoxaluric rats. Free radical toxicity in the glycollate fed rats is effectively counteracted by lipoic acid administration. Lipoic acid administration brought about a significant decrease in peroxidative levels with an increase in catalase activity and glutathione level. These observations highlight the antioxidant property of alpha-lipoic acid and its cytoprotective action against experimental hyperoxaluria.


Pharmacol Res


Pharmacological research


Sumathi R,Jayanthi S,Kalpanadevi V,Varalakshmi P




Has Abstract


1993-05-01 00:00:00














  • Antiretroviral drugs in HIV-infected children.

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    journal_title:Pharmacological research

    pub_type: 社论,评审


    authors: Viganò A,Manfredini V,Penagini F,Giacomet V,Zuccotti GV

    更新日期:2011-07-01 00:00:00

  • Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation.

    abstract::Mast cells take part of armamentarium immunologic for host defense against parasitic and bacterial infections. They are derived from bone marrow progenitors and can be activated by immunological and chemical stimuli in order to get its degranulation. The activation of mast cells generates a signalling cascade leaded t...

    journal_title:Pharmacological research

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    更新日期:2010-09-01 00:00:00

  • Biosimilars in rheumatology.

    abstract::Biotechnologicals are an invaluable resource in the treatment of patients with inflammatory rheumatic diseases (IRD) non-responsive or intolerant to conventional therapies. However, they are the main driver for increase in direct costs and represent a significant economic burden to healthcare systems worldwide. Since ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Araújo FC,Gonçalves J,Fonseca JE

    更新日期:2019-11-01 00:00:00

  • Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats.

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    journal_title:Pharmacological research

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    authors: Quirós Y,Blanco-Gozalo V,Sanchez-Gallego JI,López-Hernandez FJ,Ruiz J,Perez de Obanos MP,López-Novoa JM

    更新日期:2016-05-01 00:00:00


    abstract:BACKGROUND:Many flavonoids have various beneficial actions like anti-inflammatory, anti-carcinogenic properties and many other clinical conditions. Astilbin is one such flavanoid compound having many physiological as well as pharmacological actions. PURPOSE:To summarize the important findings from the research conduct...

    journal_title:Pharmacological research

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    authors: Sharma A,Gupta S,Chauhan S,Nair A,Sharma P

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  • Anti-arrhythmic drug therapy in implantable cardioverter-defibrillator recipients.

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    journal_title:Pharmacological research

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    authors: Tan BWQ,Sim WL,Cheong JK,Kuan WS,Tran T,Lim HF

    更新日期:2020-10-01 00:00:00

  • Inhibition of poly(ADP-ribose) polymerase prevents vascular hyporesponsiveness induced by lipopolysaccharide in isolated rat aorta.

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    authors: Tasatargil A,Dalaklioglu S,Sadan G

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  • Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes.

    abstract::The aim of this study was to investigate effect of antiemetics on G6PD and antioxidant enzymes. Antiemetics are currently being used to reduce or prevent nausea and vomiting in patients. This is the first study to show effect of antiemetics on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities....

    journal_title:Pharmacological research

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    authors: Ozmen I,Küfrevioglu OI

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  • Short-term effects of Poly(I:C) on gut permeability.

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    journal_title:Pharmacological research

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    authors: Speisky H,Cassels BK

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Cosentino M,Marino F,Ferrari M,Rasini E,Bombelli R,Luini A,Legnaro M,Delle Canne MG,Luzzani M,Crema F,Paracchini S,Lecchini S

    更新日期:2007-08-01 00:00:00

  • The effect of morbid obesity on morphine glucuronidation.

    abstract::The purpose of the present work was to study the change in morphine metabolic ratio in obese subjects before and after Roux-en-Y Gastric Bypass (RYGB) and to identify clinical and/or biological factors associated with this change. The pharmacokinetics (PK) of oral morphine (30mg), morphine-3-glucuronide (M3G) and morp...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lloret-Linares C,Luo H,Rouquette A,Labat L,Poitou C,Tordjman J,Bouillot JL,Mouly S,Scherrmann JM,Bergmann JF,Declèves X

    更新日期:2017-04-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Bryła J,Lietz T,Jarzyna R,Michalik M,Pietkiewicz J

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    pub_type: 历史文章,杂志文章,评审


    authors: Guidotti A,Grayson DR

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