Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.

Abstract:

:Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multi-function of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Zheng P,Wang Q,Teng J,Chen J

doi

10.1016/j.phrs.2015.05.001

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

11-5

eissn

1043-6618

issn

1096-1186

pii

S1043-6618(15)00084-5

journal_volume

99

pub_type

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