Abstract：
:The perioperative period is supposed to be a vulnerable period for cancer progression. Results of clinical studies indicate that the use of regional anesthesia can influence and improve oncological outcome of cancer patients. Uncontrolled cell proliferation and resistance to apoptotic cell death are important characteristics of solid tumors. The aim of this study was to investigate the effects of the clinically used local anesthetics ropivacaine or bupivacaine and the opioid analgesic sufentanil on cell proliferation, cell cycle distribution and apoptosis of colon (HT 29 and SW 480) and pancreatic (PaTu 8988t and PANC 1) cancer cell lines in vitro. Cell proliferation was measured by Cell Proliferation ELISA BrdU Assay. Apoptosis was analyzed by annexin V staining and cell cycle distribution was detected by flow cytometry. Ropivacaine, bupivacaine and sufentanil did not change apoptosis rate and cell cycle distribution in clinically concentration. Only high concentrations of ropivacaine or bupivacaine revealed antiproliferative potency. Protective effects of epidural anesthesia observed in clinical studies seem not to be based on direct effects of these drugs on cancer cells.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Bundscherer A,Malsy M,Gebhardt K,Metterlein T,Plank C,Wiese CH,Gruber M,Graf BMdoi
10.1016/j.phrs.2015.03.017subject
Has Abstractpub_date
2015-05-01 00:00:00pages
126-31eissn
1043-6618issn
1096-1186pii
S1043-6618(15)00056-0journal_volume
95-96pub_type
杂志文章abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...
journal_title：Pharmacological research
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更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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更新日期：2020-11-16 00:00:00
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更新日期：2012-03-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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更新日期：2020-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2004.05.007
更新日期：2004-11-01 00:00:00
