Abstract：
:(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg-1, 30 min before the test, significantly decreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg-1) diminished the protective activity of diphenylhydantoin, phenobarbital and valproate, but not that of carbamazepine against maximal electroshock. The effect of 3-PPP upon the electroconvulsive threshold and the 3-PPP-induced inhibition of the protective action of antiepileptics was reversed by haloperidol (0.5 mg kg-1). Moreover, 3-PPP did not alter the total and free plasma levels of antiepileptic drugs, so a pharmacokinetic interaction is not probable. The combined treatment of 3-PPP with antiepileptic drugs, providing a 50% protection against maximal electroshock, did not affect motor performance in mice, although resulted in significant long-term memory deficits. Our data indicate that sigma receptor-mediated events may play some role in seizure processes in the central nervous system and can modulate the protective activity of some conventional antiepileptic drugs.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Borowicz KK,Kleinrok Z,Czuczwar SJdoi
10.1006/phrs.1999.0548keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
509-16issue
6eissn
1043-6618issn
1096-1186pii
S1043-6618(99)90548-0journal_volume
40pub_type
杂志文章abstract：:Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p.o.). In the same dose range, oxaceprol was comparable to indomethacin (3 mg/kg p.o.) as an inhibitor of yeast hyperalgaesia an...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0051
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journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
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pub_type： 杂志文章
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0026
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更新日期：2015-05-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2008-11-01 00:00:00
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更新日期：2007-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2004.02.008
更新日期：2004-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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doi：10.1016/1043-6618(94)80041-3
更新日期：1994-02-01 00:00:00
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更新日期：2016-12-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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更新日期：2017-04-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2016-09-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2020-04-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：1995-09-01 00:00:00
abstract：:Despite the exploration of a large number of disparate drugs in animal models and clinical trials, no pharmacological intervention, with the exception of aggressive lipid lowering therapy has reduced late vein graft failure in man. The importance of devising more effective strategies is exemplified by the enormous eco...
journal_title：Pharmacological research
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更新日期：2018-01-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2018-09-01 00:00:00
abstract：:It is a consensus view that a strategy to increase heart resistance to ischaemia-reperfusion is a warranted. Here, based on our previous study, we have hypothesized that a nicotinamide-rich diet could increase myocardial resistance to ischaemia-reperfusion. Therefore, the purpose of this study was to determine whether...
journal_title：Pharmacological research
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更新日期：2010-06-01 00:00:00
abstract：:Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...
journal_title：Pharmacological research
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更新日期：2003-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
abstract：:Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over decades, only a few drugs were approved by Food and Drug Administration (FDA) and most ended in failure. The lessons learned have switched the strategy of drug discovery from designing highly selective ligands to a network pharm...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
abstract：:Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1006/phrs.1997.0254
更新日期：1997-12-01 00:00:00
