Lean body weight is the best scale for venous thromboprophylaxis algorithm in severely obese patients undergoing bariatric surgery.

abstract：:The survey was carried out, between September 1995 and May 1996, in order to describe the prescriptive behaviour among Sicilian general practitioners (GPs) in choosing an empirical antibiotic regimen for LRTIs in adult patients and begin an educational process which involves the same GPs in decisions regarding their p...

journal_title：Pharmacological research

authors： Mazzaglia G,Arcoraci V,Greco S,Cucinotta G,Cazzola M,Caputi AP

更新日期：1999-07-01 00:00:00

abstract：:DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

journal_title：Pharmacological research

authors： Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

更新日期：2010-02-01 00:00:00

abstract：:There is evidence that hydrazine, a metabolite of isoniazid, plays an important role in the mechanism of isoniazid-induced hepatotoxicity. Hydrazine has been reported to be metabolised by NADPH cytochrome P-450 reductase (reductase) to reactive and potentially toxic intermediates. The present study was designed, using...

journal_title：Pharmacological research

authors： Sarich TC,Adams SP,Wright JM

更新日期：1998-09-01 00:00:00

abstract：:The gut microbiota and its short chain fatty acid (SCFA) metabolites have been established to play an important protective role against neurodegenerative diseases. Our previous study demonstrated that cerebral ischemic stroke triggers dysfunctional gut microbiota and increased intestinal permeability. In this study, w...

journal_title：Pharmacological research

authors： Chen R,Xu Y,Wu P,Zhou H,Lasanajak Y,Fang Y,Tang L,Ye L,Li X,Cai Z,Zhao J

更新日期：2019-10-01 00:00:00

abstract：:The present study was aimed at investigating the role of endogenous nitric oxide (NO) in regulating Na,K-ATPase activity in the kidney. The expression of alpha-1 and beta-1 subunits; and the enzymatic activity of Na,K-ATPase were determined in the kidney of rats treated with an NO synthase inhibitor, N(G)-nitro-L-argi...

journal_title：Pharmacological research

authors： Kang DG,Kim JW,Lee J

更新日期：2000-01-01 00:00:00

abstract：:This study was performed in order to investigate the cholinomimetic response of seminal vesicles isolated from rats treated with hydrocortisone acetate during perinatal life. At the adult phase, the body weight and the wet weight of the seminal vesicle of these animals were unchanged. However, these male rats exhibite...

journal_title：Pharmacological research

authors： Pereira OC,Yasuhara F,Arena AC

更新日期：2003-07-01 00:00:00

abstract：:The aim of the present pilot study was to characterise the renal elimination of betalains after consumption of red beet juice (RBJ). Six healthy, non-smoking female volunteers were given a single oral dose of either 500 mL of a commercial RBJ containing 362.7 mg of betalains and 500 mL of tap water, respectively, in a...

journal_title：Pharmacological research

authors： Frank T,Stintzing FC,Carle R,Bitsch I,Quaas D,Strass G,Bitsch R,Netzel M

更新日期：2005-10-01 00:00:00

abstract：:TMEM16A plays critical roles in physiological process and may serve as drug targets for diverse diseases. Recently, TMEM16A has started to be regarded as potential primary lung adenocarcinoma targets. Here, we identified that arctigenin, a natural compound, is a novel TMEM16A inhibitor, and it can suppress lung adenoc...

journal_title：Pharmacological research

authors： Guo S,Chen Y,Shi S,Wang X,Zhang H,Zhan Y,An H

更新日期：2020-05-01 00:00:00

abstract：:Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...

journal_title：Pharmacological research

authors： Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

更新日期：2001-03-01 00:00:00

abstract：:In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABA(A)receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [(3)H]MK-801 binding, and the GABA(A)receptor bindings we...

journal_title：Pharmacological research

authors： Kim HS,Hwang SL,Nah SY,Oh S

更新日期：2001-05-01 00:00:00

abstract：:Quiescent hepatic stellate cell (HSC) activation and subsequent conversion into myofibroblasts is the central event in hepatic fibrosis pathogenesis. Epithelial-mesenchymal transition (EMT), another vital participant in liver fibrosis, has the potential to initiate HSC activation, which promotes abundant myofibroblast...

journal_title：Pharmacological research

authors： Zhao H,Wang Z,Tang F,Zhao Y,Feng D,Li Y,Hu Y,Wang C,Zhou J,Tian X,Yao J

更新日期：2018-02-01 00:00:00

abstract：:Folic acid-conjugated albumin nanospheres (FA-AN) have been developed to provide an actively targetable drug delivery system for improved drug targeting of cancer cells with reduced side effects. The nanospheres were prepared by conjugating folic acid onto the surface of albumin nanospheres using 1-ethyl-3-(3-dimethyl...

journal_title：Pharmacological research

authors： Shen Z,Li Y,Kohama K,Oneill B,Bi J

更新日期：2011-01-01 00:00:00

abstract：:Several studies have demonstrated that any beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins), of which simvastatin (Merck Sharp & Dohme) is an example, on coronary events are linked to their hypocholesterolemic properties. The in vivo effects of simvastatin treatment ...

journal_title：Pharmacological research

authors： Pioruńska-Stolzmann M,Pioruńska-Mikołajczak A

更新日期：2001-04-01 00:00:00

abstract：:N-acetyl penicillamine (NAP), a derivative of penicillamine and copper chelator has been employed as a potential protector of host stress organ injury during Plasmodium berghei infection in mice. Intramuscular injection of NAP (60 mg kg-1 body wt for 10 days) to P. berghei mice was able to restrict the hepato- and spl...

journal_title：Pharmacological research

authors： Srivastava P,Arif AJ,Singh C,Pandey VC

更新日期：1997-10-01 00:00:00

abstract：:Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphor...

journal_title：Pharmacological research

authors： Lee C,Rhee I

更新日期：2019-06-01 00:00:00

abstract：:Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6....

journal_title：Pharmacological research

authors： Chae HJ,Kim SC,Chae SW,An NH,Kim HH,Lee ZH,Kim HR

更新日期：2001-03-01 00:00:00

abstract：:Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-beta-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to influence halothane...

journal_title：Pharmacological research

authors： Harrison GG,Dyer RA,Llewellyn RL,James MF

更新日期：1999-02-01 00:00:00

abstract：:Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia (CML). In the present study, we conducted a systematic review and meta-analysis of published studies to estimate the impac...

journal_title：Pharmacological research

authors： Cargnin S,Ravegnini G,Soverini S,Angelini S,Terrazzino S

更新日期：2018-05-01 00:00:00

abstract：:Male Swiss Webster mice exhibited antinociception, hypothermia and Straub tail 3h following a 75mg morphine pellet implantation. These signs disappeared by 72h, and the morphine-pelleted mice were indistinguishable from placebo-pelleted ones, although brain morphine concentrations ranged from 200 to 400ng/gm. We previ...

journal_title：Pharmacological research

authors： Smith FL,Javed RR,Smith PA,Dewey WL,Gabra BH

更新日期：2006-12-01 00:00:00

abstract：:An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

journal_title：Pharmacological research

authors： Giacobini E

更新日期：2004-10-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR. Unfortunately, due to the secondary mutation in EGFR, eventual drug-resistance is inevitable. Therefore, to overcome the resistance, new agent is urgen...

journal_title：Pharmacological research

authors： Xie YJ,Gao WN,Wu QB,Yao XJ,Jiang ZB,Wang YW,Wang WJ,Li W,Hussain S,Liu L,Leung EL,Fan XX

更新日期：2020-09-01 00:00:00

abstract：:In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335...

journal_title：Pharmacological research

authors： Singh R,Nath A,Gupta PP,Shulka M,Khare SK,Kundu B

更新日期：1998-05-01 00:00:00

abstract：:Kindling represents an accepted model of human epileptogenesis. Furthermore, it has been demonstrated that kindled rats show a diminished learning performance in an active avoidance task. In our study we administered different nootropic drugs to kindled rats to test their effects on learning a two-way active avoidance...

journal_title：Pharmacological research

authors： Becker A,Grecksch G

更新日期：1995-09-01 00:00:00

abstract：:Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which is a hallmark of cancer. The altered energy metabolism not only provides cancer cell with ATP for cellular energy, but also generate essen...

journal_title：Pharmacological research

authors： Abdel-Wahab AF,Mahmoud W,Al-Harizy RM

更新日期：2019-12-01 00:00:00

abstract：:Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack...

journal_title：Pharmacological research

authors： Wu T,Yu GY,Xiao J,Yan C,Kurihara H,Li YF,So KF,He RR

更新日期：2018-07-01 00:00:00

abstract：:Flt3 is expressed by early myeloid and lymphoid progenitor cells and it regulates the proliferation and differentiation of hematopoietic cells. Flt3 is activated by the Flt3 ligand, the monomeric form of which is a polypeptide of about 200 amino acid residues. Both membrane-associated and soluble Flt3 ligands, which a...

journal_title：Pharmacological research

authors： Roskoski R Jr

更新日期：2020-05-01 00:00:00

abstract：:Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

journal_title：Pharmacological research

authors： Mougenot N,Médiani O,Lechat P

更新日期：2005-04-01 00:00:00

abstract：:Growth differentiation factor 11 (GDF11) is a novel factor with controversial effects on cardiac hypertrophy both in vivo and in vitro. Although recent evidence has corroborated that GDF11 prevents the development of cardiac hypertrophy, its molecular mechanism remains unclear. In our previous work, we showed that nor...

journal_title：Pharmacological research

authors： Garrido-Moreno V,Díaz-Vegas A,López-Crisosto C,Troncoso MF,Navarro-Marquez M,García L,Estrada M,Cifuentes M,Lavandero S

更新日期：2019-08-01 00:00:00

abstract：:Fish represent the oldest and most diverse classes of vertebrates, comprising around the 48% of the known member species in the subphylum Vertebrata. There are many scientific fields that use fish as models in research, including respiratory and cardiovascular research, cell culture, ecotoxicology, ageing, pharmacolog...

journal_title：Pharmacological research

authors： Bolis CL,Piccolella M,Dalla Valle AZ,Rankin JC

更新日期：2001-10-01 00:00:00

abstract：:The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening the cytoskeleton of ASM. Although the underlying mechanism is not entirely cle...

journal_title：Pharmacological research

authors： Wang L,Chitano P,Seow CY

更新日期：2020-09-01 00:00:00