Abstract：
:The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Pini A,Obara I,Battell E,Chazot PL,Rosa ACdoi
10.1016/j.phrs.2016.06.021subject
Has Abstractpub_date
2016-09-01 00:00:00pages
316-324eissn
1043-6618issn
1096-1186pii
S1043-6618(16)30595-3journal_volume
111pub_type
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