Abstract:
:A new class of methylfuroxans and methylfurazans arylthio, arylsulphinyl and arylsulphonyl substituted, characterized by vasodilating and antiaggregatory properties, is described. Vasodilating activity, tested on rabbit aortic rings percontracted with 1 microM noradrenaline, is enhanced by N-oxidation of the furazan ring and is maximized by increase of the sulphur atom oxidation level. Compounds 4-methyl-3-(p-methoxyphenylsulphonyl) furoxan 6c, 3-phenyl-4-phenylsulphonylfuroxan 10, 4-phenyl-3-phenylsulphonylfuroxan 11 and 3,4-bis(phenyl-sulphonyl)furoxan 12 (EC50 values ranging between 0.055-1.07 microM), seem to be promising since they show the highest potency as well as maximal efficacy, causing complete reversal of noradrenaline induced contraction. The structure-activity relationship, observed in the platelet aggregation test, is substantially similar to that reported for the vasodilating activity, in line with the general profile of these drugs as putative NO-mimetic derivatives.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Ferioli R,Fazzini A,Folco GC,Fruttero R,Calvino R,Gasco A,Bongrani S,Civelli Mdoi
10.1006/phrs.1993.1123subject
Has Abstractpub_date
1993-10-01 00:00:00pages
203-12issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(83)71123-0journal_volume
28pub_type
杂志文章abstract::We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...
journal_title:Pharmacological research
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doi:10.1016/s1043-6618(05)80067-2
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journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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doi:10.1016/j.phrs.2004.02.005
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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doi:10.1006/phrs.1999.0610
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abstract::In 1996, Dr. Costa was invited by Prof. Boris Astrachan, Chairman of the Department of Psychiatry at the University of Illinois at Chicago, to direct the research of the "Psychiatric Institute, Department of Psychiatry, School of Medicine, at the University of Illinois at Chicago." He was asked to develop a seminal re...
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pub_type: 历史文章,杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2007.09.009
更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Pharmacological research
pub_type: 临床试验,杂志文章
doi:10.1006/phrs.1998.0370
更新日期:1998-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2020.104659
更新日期:2020-03-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2016.09.019
更新日期:2016-11-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2003.12.016
更新日期:2004-07-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2015.12.024
更新日期:2016-02-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2017.11.025
更新日期:2018-03-01 00:00:00