The acute alterations in biochemistry, morphology, and contractility of rat-isolated terminal ileum via increased intra-abdominal pressure.

abstract：:Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like...

journal_title：Pharmacological research

authors： Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L

更新日期：2012-01-01 00:00:00

abstract：:The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin ...

journal_title：Pharmacological research

authors： Sautebin L,Carnuccio R,Ialenti A,Di Rosa M

更新日期：1992-01-01 00:00:00

abstract：:Although calcimimetics were developed to block parathyroid hormone synthesis, some reports suggest that they may also reduce blood pressure by unknown mechanisms. Calcimimetic-induced changes in the synthesis of endothelial vasoactive factors could be involved. Wistar rats were treated with the calcimimetic R-568, and...

journal_title：Pharmacological research

authors： Martínez-Miguel P,Medrano-Andrés D,Lopes-Martín V,Arribas-Gómez I,Rodríguez-Puyol M,Rodríguez-Puyol D,López-Ongil S

更新日期：2013-10-01 00:00:00

abstract：:The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

journal_title：Pharmacological research

authors： Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

更新日期：1999-11-01 00:00:00

abstract：:Kidney injury is one of the main complications of obstructive jaundice (OJ) and its pathogenesis has not been clarified. As an independent risk factor for OJ associated with significant morbidity and mortality, it can be mainly divided into two types of morphological injury and functional injury. We called these dysfu...

journal_title：Pharmacological research

authors： Liu J,Qu J,Chen H,Ge P,Jiang Y,Xu C,Chen H,Shang D,Zhang G

更新日期：2021-01-01 00:00:00

abstract：:A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...

journal_title：Pharmacological research

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-11-01 00:00:00

abstract：:Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the presence of a δ subunit in the receptor complex. δ-Containing receptors respond to low ambient concentrations of GABA, or respond to spillover of GABA from the synapse, and give rise to tonic inhibitory currents. In ce...

journal_title：Pharmacological research

authors： Ahring PK,Bang LH,Jensen ML,Strøbæk D,Hartiadi LY,Chebib M,Absalom N

更新日期：2016-09-01 00:00:00

abstract：:There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

journal_title：Pharmacological research

authors： Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

更新日期：2016-09-01 00:00:00

abstract：:The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

journal_title：Pharmacological research

authors： Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

更新日期：1993-02-01 00:00:00

abstract：:Pulsatilla Decoction (Bai-Tou-Weng-Tang) has been used medically in China for thousands of years for the treatment of diseases caused by bacteria. In recent decades, Pulsatilla Decoction is becoming a well-known formula prescription used for the treatment of ulcerative colitis in traditional Chinese medicine. Pulsatil...

journal_title：Pharmacological research

authors： Li YH,Zou M,Han Q,Deng LR,Weinshilboum RM

更新日期：2020-10-01 00:00:00

abstract：:Bioequivalence studies are mainly required to demonstrate the interchangeability of multisource pharmaceutical products, usually called generics. A pivotal investigation projected and conducted in compliance with specific guidelines allows a replicative company to register a generic drug via an ANDA (abbreviated new d...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1995-10-01 00:00:00

abstract：:Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects...

journal_title：Pharmacological research

authors： Garbarino VR,Santos TA,Nelson AR,Zhang WQ,Smolik CM,Javors MA,Daws LC,Gould GG

更新日期：2019-02-01 00:00:00

abstract：:This brief overview is focused on the inherent duality of immune responses: on the one hand they may induce inflammation and precipitate injury, on the other, a number of examples of participation in organ and tissue repair are growing. These processes will be reviewed from the nephrological stand-point. Specifically,...

journal_title：Pharmacological research

authors： Goligorsky MS

更新日期：2008-08-01 00:00:00

abstract：:Prader-Willi syndrome (PWS), the leading genetic cause of obesity, is characterized by a striking hyperphagic behavior that can lead to obesity, type-2 diabetes, cardiovascular disease and death. The molecular mechanism underlying impaired satiety in PWS is unknown. Oleoylethanolamide (OEA) is a lipid mediator involve...

journal_title：Pharmacological research

authors： Igarashi M,Narayanaswami V,Kimonis V,Galassetti PM,Oveisi F,Jung KM,Piomelli D

更新日期：2017-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...

journal_title：Pharmacological research

authors： Bourre L,Thibaut S,Briffaud A,Lajat Y,Patrice T

更新日期：2002-02-01 00:00:00

abstract：:Some macrolide antibiotics have been shown to produce significant drug-drug interactions through the inhibition of cytochrome P450 (CYP) enzymes. In renal transplant patients these interactions pose potentially serious problems for the safe administration of cyclosporine A (CSA), a substrate of CYP3A4. The effects of ...

journal_title：Pharmacological research

authors： Bachmann K,Jauregui L,Chandra R,Thakker K

更新日期：2003-06-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are used widely for the treatment of acid-related disorders. Despite their excellent efficacy and tolerance, the pharmacodynamics and pharmacokinetics of PPIs are affected by each patient's CYP2C19 and gastric H+,K+-ATPase genotype. The aim of this review was to analyze the effect of gene...

journal_title：Pharmacological research

authors： Zhang HJ,Zhang XH,Liu J,Sun LN,Shen YW,Zhou C,Zhang HW,Xie LJ,Chen J,Liu Y,Wang YQ

更新日期：2020-02-01 00:00:00

abstract：:The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied. The results show that EEP and WSD led to decreased levels of blood glucose (FBG), fructosamine (FRU), malonaldehyde (MDA), nitric oxi...

journal_title：Pharmacological research

authors： Fuliang HU,Hepburn HR,Xuan H,Chen M,Daya S,Radloff SE

更新日期：2005-02-01 00:00:00

abstract：:Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In th...

journal_title：Pharmacological research

authors： Genario R,Cipolla-Neto J,Bueno AA,Santos HO

更新日期：2021-01-01 00:00:00

abstract：:Vascular responses to hypoxia are heterogeneous and involve the release of vasodilators substances such as nitric oxide (NO) and prostacyclin (PGI(2)). In vitro studies have shown that Vitamin K(1) modulates the release of arachidonic acid (AA) in vascular cells, and thus inhibits the capacity of blood vessels to synt...

journal_title：Pharmacological research

authors： Tirapelli CR,Mingatto FE,De Godoy MA,Ferreira R,De Oliviera AM

更新日期：2002-12-01 00:00:00

abstract：:Ocotea quixos essential oil was shown to possess significant inhibitory activity of platelet aggregation and clot retraction in rodent plasma. This study is aimed at fully characterizing the antiplatelet activity of the whole essential oil and its main components trans-cinnamaldehyde and methyl cinnamate also in human...

journal_title：Pharmacological research

authors： Ballabeni V,Tognolini M,Bertoni S,Bruni R,Guerrini A,Rueda GM,Barocelli E

更新日期：2007-01-01 00:00:00

abstract：:Aminoglycoside antibiotics are employed clinically because of their potent bactericidal activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs belong to this class are well-known to cause nephrotoxicity, which limits their frequent clinical exploitation. Gentamicin, a commonly used...

journal_title：Pharmacological research

authors： Balakumar P,Rohilla A,Thangathirupathi A

更新日期：2010-09-01 00:00:00

abstract：:Apoptosis of tissues may contribute to ischaemia-reperfusion injury. The aim of the present study was to determine whether administration of a colloid solution would prevent apoptosis after liver ischaemia-reperfusion. New Zealand rabbits, weighing 1.5-2 kg, were randomized to receive either 4% SG (20 ml kg (-1)h(-1) ...

journal_title：Pharmacological research

authors： Altunkan A,Aydin O,Ozer Z,Colak T,Bilgin E,Oral U

更新日期：2002-06-01 00:00:00

abstract：AIM:To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation. METHODS:We enrolled 532 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of...

journal_title：Pharmacological research

authors： Derosa G,Maffioli P,Scelsi L,Bestetti A,Vanasia M,Cicero AFG,Spinardi L,Bentivenga C,Esposti DD,Caprio M,Borghi C,Pitt B,Cosentino E

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF THE RESEARCH:Overexpression of the human dimethylarginine dimethylaminohydrolase type 1 (hDDAH1) gene was reported to have beneficial cardiovascular effects in mice. To date, it is unclear whether these effects are related to enhanced metabolic clearance of asymmetric dimethylarginine (ADMA) and l-N(G)-mono-...

journal_title：Pharmacological research

authors： Schwedhelm E,von Leitner EC,Atzler D,Schmitz C,Jacobi J,Meinertz T,Münzel T,Baldus S,Cooke JP,Böger RH,Maas R,Sydow K

更新日期：2009-12-01 00:00:00

abstract：:Major depressive disorder is a worrying mental health problem and obtaining remission from treatment resistant depression (TRD) remains an important clinical issue. Twenty patients (14 women, 6 men) considered as treatment resistant after the fourth step of a seven-step treatment algorithm to obtain remission in major...

journal_title：Pharmacological research

authors： Gervasoni N,Aubry JM,Gex-Fabry M,Bertschy G,Bondolfi G

更新日期：2009-03-01 00:00:00

abstract：:The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus is reviewed. The involvement of these receptors in the hippocampus is suggested by data that ATP is released from hippocampal slices [1] and that it also induces fast synaptic currents in cultured hippocampal neuro...

journal_title：Pharmacological research

authors： Inoue K

更新日期：1998-11-01 00:00:00

abstract：:Macroscale delivery systems that can be locally implanted on the tumor tissue as well as avoid all the complications associated to the systemic delivery of therapeutics have captured researchers' attention, in recent years. Particularly, the microneedle-based devices can be used to efficiently deliver both small and m...

journal_title：Pharmacological research

authors： Moreira AF,Rodrigues CF,Jacinto TA,Miguel SP,Costa EC,Correia IJ

更新日期：2019-10-01 00:00:00

abstract：:Exposure to ionizing radiation causes damage to living tissues; however, only a small number of agents have been approved for use in radiation injuries. Radioprotector is the primary countermeasure to radiation injury and none radioprotector has indeed reached the drug development stage. Repurposing the long list of a...

journal_title：Pharmacological research

authors： Ren L,Xie D,Li P,Qu X,Zhang X,Xing Y,Zhou P,Bo X,Zhou Z,Wang S

更新日期：2016-11-01 00:00:00

abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

journal_title：Pharmacological research

authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

更新日期：2007-12-01 00:00:00