Lipocortin and vasocortin: two species of anti-inflammatory proteins mimicking the effects of glucocorticoids.

abstract：:The survey was carried out, between September 1995 and May 1996, in order to describe the prescriptive behaviour among Sicilian general practitioners (GPs) in choosing an empirical antibiotic regimen for LRTIs in adult patients and begin an educational process which involves the same GPs in decisions regarding their p...

journal_title：Pharmacological research

authors： Mazzaglia G,Arcoraci V,Greco S,Cucinotta G,Cazzola M,Caputi AP

更新日期：1999-07-01 00:00:00

abstract：:Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow (P. notoginseng) is a highly valued Chinese materia medica having a hemostatic effect and mainly used for the treatment of trauma and ischemic cardiovascular diseases. Stringent growth requirements, weak resistance to insect pests and plant diseases, arsenic contami...

journal_title：Pharmacological research

authors： Yang BR,Yuen SC,Fan GY,Cong WH,Leung SW,Lee SM

更新日期：2018-08-01 00:00:00

abstract：:Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

journal_title：Pharmacological research

authors： Epstein AN

更新日期：1992-02-01 00:00:00

abstract：:In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study,we introduced the current ...

journal_title：Pharmacological research

authors： Wu W,Tang Z,Chen J,Gao Y

更新日期：2019-10-01 00:00:00

abstract：:Postnatal bone marrow contains a subtype of unique progenitor cells that have the capacity to differentiate into functional endothelial cells. Hence, these cells have been termed endothelial progenitor cells (EPCs). In general, circulating EPCs were characterized by the expression of CD133, CD34 and the vascular endot...

journal_title：Pharmacological research

authors： Hristov M,Weber C

更新日期：2008-08-01 00:00:00

abstract：:The effects of trans-resveratrol (RSV) combined with ethanol (EtOH) were evaluated by (31)P NMR on total ATP and sn-glycerol-3-phosphate (sn-G3P) contents measured in real time in isolated and perfused whole liver of the rat. Mitochondrial ATP turnover was assessed by using specific inhibitors of glycolytic and mitoch...

journal_title：Pharmacological research

authors： Gallis JL,Serhan N,Gin H,Couzigou P,Beauvieux MC

更新日期：2012-03-01 00:00:00

abstract：:Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

journal_title：Pharmacological research

authors： Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

更新日期：2005-06-01 00:00:00

abstract：:Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our...

journal_title：Pharmacological research

authors： Liu J,Yue S,Yang Z,Feng W,Meng X,Wang A,Peng C,Wang C,Yan D

更新日期：2018-08-01 00:00:00

abstract：:The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseas...

journal_title：Pharmacological research

authors： Hu B,Phan SH

更新日期：2016-06-01 00:00:00

abstract：:Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infect...

journal_title：Pharmacological research

authors： McKee DL,Sternberg A,Stange U,Laufer S,Naujokat C

更新日期：2020-07-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic...

journal_title：Pharmacological research

authors： Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi D

更新日期：2014-04-01 00:00:00

abstract：:The antinociceptive effect of the D(2) antagonist prochlorperazine was examined in the mouse hot-plate and abdominal constriction tests. Prochlorperazine (1-2 mg kg(-1) s.c./i.p.) produced an increase of the pain threshold in the mouse hot-plate test. The antinociception produced by prochlorperazine was prevented by t...

journal_title：Pharmacological research

authors： Ghelardini C,Galeotti N,Uslenghi C,Grazioli I,Bartolini A

更新日期：2004-09-01 00:00:00

abstract：:This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent wi...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Nikolaidis E,Kounenis G

更新日期：2001-09-01 00:00:00

abstract：:DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

journal_title：Pharmacological research

authors： Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

更新日期：2010-02-01 00:00:00

abstract：:Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10...

journal_title：Pharmacological research

authors： Balakumar P,Varatharajan R,Nyo YH,Renushia R,Raaginey D,Oh AN,Akhtar SS,Rupeshkumar M,Sundram K,Dhanaraj SA

更新日期：2014-12-01 00:00:00

abstract：:The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of...

journal_title：Pharmacological research

authors： Alama A,Barbieri F,Cagnoli M,Schettini G

更新日期：1997-09-01 00:00:00

abstract：:Experiments were designed to evaluate the mechanisms of propofol and adenosine in rat atrial muscle. Atria were suspended in the isolated organ bath system for isometric tension recording and response to propofol and adenosine were tested in the absence and presence of glibenclamide, N(G)-nitro-arginine-methyl-ester (...

journal_title：Pharmacological research

authors： Cinel I,Gür S

更新日期：2000-08-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is an endogenously produced signaling molecule synthesized by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). Given that H2S exerts significant effects on bioenergetics and metabolism, the goal of the current study was to determine th...

journal_title：Pharmacological research

authors： Katsouda A,Szabo C,Papapetropoulos A

更新日期：2018-02-01 00:00:00

abstract：:The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-...

journal_title：Pharmacological research

authors： Jeong HJ,Yi JM,Hong SH,Kong JY,Kim KS,Won JH,Cho KH,Shin TY,Kim HS,Kim HM

更新日期：2002-11-01 00:00:00

abstract：:Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptome analysis, we comp...

journal_title：Pharmacological research

authors： Chen Y,Brooks MJ,Gieser L,Swaroop A,Palczewski K

更新日期：2017-01-01 00:00:00

abstract：:The synergistic protective effect of nicorandil (KATP channel opener) and amlodipine (calcium channel blocker) on mitochondrial respiration and mitochondrial lipid contents were examined on isoproterenol-induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for 2 days showed s...

journal_title：Pharmacological research

authors： Sathish V,Ebenezar KK,Devaki T

更新日期：2003-12-01 00:00:00

abstract：:To minimize irreversible brain injury after acute ischemic stroke (AIS), the time to treatment (i.e., treatment delay) should be minimized. However, thus far, all cytoprotective clinical trials have failed. Analysis of literature identified short treatment durations (≤72 h) as a common motif among completed cytoprotec...

journal_title：Pharmacological research

authors： Gaidhani N,Uteshev VV

更新日期：2018-10-01 00:00:00

abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

journal_title：Pharmacological research

authors： Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

更新日期：2000-01-01 00:00:00

abstract：:Cytophotometric measurement of the effect of praziquantel (500 mg/kg for 2 days) versus hycanthone (60 mg/kg for 3 days) on hepatocyte nuclear deoxyribonucleic acid (DNA) content was evaluated in Schistosoma mansoni infected mice. Drugs were given 8 weeks post-infection and repeated weekly for 4 weeks. DNA values of i...

journal_title：Pharmacological research

authors： Botros SS

更新日期：1990-03-01 00:00:00

abstract：:In recent clinical observation, the growth of endothelial tumors, such as hemangiomas of infancy, was repressed by the non-selective beta-adrenergic antagonist propranolol possibly through targeting of the vascular endothelial compartment. As human brain microvascular endothelial cells (HBMEC) play an essential role a...

journal_title：Pharmacological research

authors： Annabi B,Lachambre MP,Plouffe K,Moumdjian R,Béliveau R

更新日期：2009-11-01 00:00:00

abstract：:Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. However resistance to anti-BRAF therapy usually develops within a few months and conseque...

journal_title：Pharmacological research

authors： Oliveira ÉA,Lima DS,Cardozo LE,Souza GF,de Souza N,Alves-Fernandes DK,Faião-Flores F,Quincoces JAP,Barros SBM,Nakaya HI,Monteiro G,Maria-Engler SS

更新日期：2017-11-01 00:00:00

abstract：:Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...

journal_title：Pharmacological research

authors： Cantoni O,Guidarelli A,Sestili P,Giacomoni PU,Cattabeni F

更新日期：1994-02-01 00:00:00

abstract：:The endogenous gasotransmitter hydrogen sulphide (H2S) is an important regulator of the cardiovascular system, particularly of myocardial function. Moreover, H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury, and is considered an important mediator of "ischemic preconditioning...

journal_title：Pharmacological research

authors： Testai L,Marino A,Piano I,Brancaleone V,Tomita K,Di Cesare Mannelli L,Martelli A,Citi V,Breschi MC,Levi R,Gargini C,Bucci M,Cirino G,Ghelardini C,Calderone V

更新日期：2016-11-01 00:00:00

abstract：:Etifoxine (EFX) is a non-benzodiazepine psychoactive drug which exhibits anxiolytic effects through a dual mechanism, by directly binding to GABAA receptors (GABAARs) and to the mitochondrial 18-kDa translocator protein, resulting in the potentiation of the GABAergic function. The β subunit subtype plays a key role in...

journal_title：Pharmacological research

authors： Mattei C,Taly A,Soualah Z,Saulais O,Henrion D,Guérineau NC,Verleye M,Legros C

更新日期：2019-07-01 00:00:00

abstract：:Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

journal_title：Pharmacological research

authors： Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

更新日期：2020-09-01 00:00:00