The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone.

abstract：:The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...

journal_title：Pharmacological research

authors： Turan NN,Demiryürek AT,Kanzik I

更新日期：2000-05-01 00:00:00

abstract：:In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining. Moreover, the relationship between Bcl-2, iNOS expression, and serum nitrate (NO(3)(-)) ...

journal_title：Pharmacological research

authors： Cinel I,Buyukafsar K,Cinel L,Polat A,Atici S,Tamer L,Oral U

更新日期：2002-08-01 00:00:00

abstract：:As a function of the structural modification of the steroid nucleus, the inhibitory interaction of 11 progesterone derivatives with human Na/K-ATPase (Na+/K(+)-transporting ATPase, EC 3.6.1.37), through C3-O-rhamnosylation, is either much decreased or weakly up to strongly increased, so that the rhamnosyl residue cont...

journal_title：Pharmacological research

authors： Weiland J,Schönfeld W,Menke KH,Repke KR

更新日期：1991-01-01 00:00:00

abstract：:We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) is a salt form of niclosamide and has ...

journal_title：Pharmacological research

authors： Li SL,Yan J,Zhang YQ,Zhen CL,Liu MY,Jin J,Gao JL,Xiao XL,Shen X,Tai Y,Hu N,Zhang XZ,Sun ZJ,Dong DL

更新日期：2017-01-01 00:00:00

abstract：:Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

journal_title：Pharmacological research

authors： Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

更新日期：1999-08-01 00:00:00

abstract：:A global transcriptional regulator, MgrA, was previously identified as a key determinant of virulence in Staphylococcus aureus. An 80% EtOH extract of Uncaria gambier was found to attenuate the virulence of S. aureus via its effects on MgrA. Using bioassay-guided fractionation, a polyphenolic polymer, uncariitannin, w...

journal_title：Pharmacological research

authors： Zhang H,Jiang JM,Han L,Lao YZ,Zheng D,Chen YY,Wan SJ,Zheng CW,Tan HS,Li ZG,Xu HX

更新日期：2019-09-01 00:00:00

abstract：:Apoptosis of tissues may contribute to ischaemia-reperfusion injury. The aim of the present study was to determine whether administration of a colloid solution would prevent apoptosis after liver ischaemia-reperfusion. New Zealand rabbits, weighing 1.5-2 kg, were randomized to receive either 4% SG (20 ml kg (-1)h(-1) ...

journal_title：Pharmacological research

authors： Altunkan A,Aydin O,Ozer Z,Colak T,Bilgin E,Oral U

更新日期：2002-06-01 00:00:00

abstract：:The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...

journal_title：Pharmacological research

authors： Koksel O,Yildirim C,Cinel L,Tamer L,Ozdulger A,Bastürk M,Degirmenci U,Kanik A,Cinel I

更新日期：2005-05-01 00:00:00

abstract：:Carbon-based nanomaterials have unique physicochemical properties relevant to the diagnosis and treatment of various diseases. There have been many reports indicating that carbon nanomaterials (CNMs) can interact and perturb biomolecules such as proteins and amyloid structures. This review is an attempt to reflect the...

journal_title：Pharmacological research

authors： Mohajeri M,Behnam B,Barreto GE,Sahebkar A

更新日期：2019-05-01 00:00:00

abstract：:The endogenous gasotransmitter hydrogen sulphide (H2S) is an important regulator of the cardiovascular system, particularly of myocardial function. Moreover, H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury, and is considered an important mediator of "ischemic preconditioning...

journal_title：Pharmacological research

authors： Testai L,Marino A,Piano I,Brancaleone V,Tomita K,Di Cesare Mannelli L,Martelli A,Citi V,Breschi MC,Levi R,Gargini C,Bucci M,Cirino G,Ghelardini C,Calderone V

更新日期：2016-11-01 00:00:00

abstract：:We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta...

journal_title：Pharmacological research

authors： Dinca M,Serban MC,Sahebkar A,Mikhailidis DP,Toth PP,Martin SS,Blaha MJ,Blüher M,Gurban C,Penson P,Michos ED,Hernandez AV,Jones SR,Banach M,for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

更新日期：2016-05-01 00:00:00

abstract：:The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin ...

journal_title：Pharmacological research

authors： Sautebin L,Carnuccio R,Ialenti A,Di Rosa M

更新日期：1992-01-01 00:00:00

abstract：:The perioperative period is supposed to be a vulnerable period for cancer progression. Results of clinical studies indicate that the use of regional anesthesia can influence and improve oncological outcome of cancer patients. Uncontrolled cell proliferation and resistance to apoptotic cell death are important characte...

journal_title：Pharmacological research

authors： Bundscherer A,Malsy M,Gebhardt K,Metterlein T,Plank C,Wiese CH,Gruber M,Graf BM

更新日期：2015-05-01 00:00:00

abstract：:Cardiac arrhythmia can be a serious complication during general anaesthesia of patients suffering from cardiac arrhythmias and using antiarrhythmic drugs. The aim of the present experiments was to establish the way in which lidocaine and verapamil influence haemodynamic parameters of rabbits after midazolam anaesthesi...

journal_title：Pharmacological research

authors： Wiktorowska A,Owczarek J,Orszulak-Michalak D

更新日期：1999-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized by gradual loss of cognitive functions. In the last decade, numerous research works were undertaken to investigate the pathogenesis of A...

journal_title：Pharmacological research

authors： Sadhukhan P,Saha S,Dutta S,Mahalanobish S,Sil PC

更新日期：2018-03-01 00:00:00

abstract：:The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of...

journal_title：Pharmacological research

authors： Alama A,Barbieri F,Cagnoli M,Schettini G

更新日期：1997-09-01 00:00:00

abstract：:Based on the role of ATG7 in the initiation of autophagy, autophagy can be divided into ATG7-dependent selective autophagy and ATG7-independent alternative autophagy. However, the detailed roles of two different types of autophagy in antitumor therapy have not been fully elucidated so far. Here, we for the first time ...

journal_title：Pharmacological research

authors： Zhang P,Ling L,Zheng Z,Zhang Y,Wang R,Wu M,Zhang N,Hu M,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10...

journal_title：Pharmacological research

authors： Balakumar P,Varatharajan R,Nyo YH,Renushia R,Raaginey D,Oh AN,Akhtar SS,Rupeshkumar M,Sundram K,Dhanaraj SA

更新日期：2014-12-01 00:00:00

abstract：:Despite our insufficient understanding of the exact molecular mechanisms of general anesthetics and sedatives, every year millions of children are treated with these drugs in a seemingly safe manner. However, increasing evidence particularly from animal studies has suggested the possibility for deleterious effects in ...

journal_title：Pharmacological research

authors： Ward CG,Loepke AW

更新日期：2012-03-01 00:00:00

abstract：:Pharmacokinetic of methyldopa (50 mg kg(-1)i.p.) was studied in anesthetized sham operated and sinoaortic denervated (SAD) rats by using the microdialysis technique. Vascular shunt probe was inserted into the carotid artery and concentric probe was placed in the striatum. Levels of methyldopa were measured by HPLC-EC....

journal_title：Pharmacological research

authors： Opezzo JA,Höcht C,Taira CA,Bramuglia GF

更新日期：2000-04-01 00:00:00

abstract：:This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent wi...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Nikolaidis E,Kounenis G

更新日期：2001-09-01 00:00:00

abstract：:Lipid peroxidation increased both in the liver homogenates and in the hepatic mitochondrial fraction of bile duct ligated (BDL)-rats. Although mitochondrial superoxide dismutase (SOD) activity did not change in the liver, glutathione (GSH) levels and glutathione peroxidase (GSH-Px) activity decreased in hepatic mitoch...

journal_title：Pharmacological research

authors： Alptekin N,Mehmetçik G,Uysal M,Aykaç-toker G

更新日期：1997-09-01 00:00:00

abstract：:Bombycis corpus(BC) or Bombyx Batryticatus, a batryticated silkworm and white-stiff silkworm, is a drug consisting of the dried larva of silkworm, Mobyz mori L., dead and stiffened due to the infection of Beauveria (Bals.) Vuill. In the present study, we have examined the protective effect of the water extracts agains...

journal_title：Pharmacological research

authors： Kim HJ,Lee WH,Yoon CH,Jeong JC,Nam KS,Kim HM,Choo YK,Lee MC,Kim CH

更新日期：2001-01-01 00:00:00

abstract：:The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...

journal_title：Pharmacological research

authors： Matejka M,Vescina C,Carducci CN,Alayón A,Dios A,Scarlatto E,Mamianetti A

更新日期：1990-05-01 00:00:00

abstract：:The antinociceptive and motor effects of the hydrophilic alpha 2-adrenoceptor agonist ST-91 were studied after intrathecal administration to male Wistar rats in different heat-pain tests and different test settings. Intrathecal administration of ST-91 caused a dose-dependent increase in hind paw licking latency in the...

journal_title：Pharmacological research

authors： Horváth G,Dobos I,Liszli P,Klimscha W,Szikszay M,Benedek G

更新日期：1997-06-01 00:00:00

abstract：:In recent clinical observation, the growth of endothelial tumors, such as hemangiomas of infancy, was repressed by the non-selective beta-adrenergic antagonist propranolol possibly through targeting of the vascular endothelial compartment. As human brain microvascular endothelial cells (HBMEC) play an essential role a...

journal_title：Pharmacological research

authors： Annabi B,Lachambre MP,Plouffe K,Moumdjian R,Béliveau R

更新日期：2009-11-01 00:00:00

abstract：:In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

journal_title：Pharmacological research

authors： Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

更新日期：1992-01-01 00:00:00

abstract：:Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as t...

journal_title：Pharmacological research

authors： Zheng P,Wang Q,Teng J,Chen J

更新日期：2015-09-01 00:00:00

abstract：:It is generally accepted that divalent cations are involved in the nociceptive pathway. The effect of systemic co-administration of magnesium sulfate and calcium channel blockers (nifedipine, verapamil) on the analgesic effect of opioid (mixed mu/kappa: butorphanol) and non-opioid drugs (paracetamol) was investigated....

journal_title：Pharmacological research

authors： Assi AA

更新日期：2001-06-01 00:00:00

abstract：:Alzheimer's disease is the fourth largest cause of death for people over 65 years of age. Dementia of Alzheimer's type is the commonest form of dementia, the other two forms being vascular dementia and mixed dementia. At present, the therapy of Alzheimer's disease is aimed at improving both, cognitive and behavioural ...

journal_title：Pharmacological research

authors： Sonkusare SK,Kaul CL,Ramarao P

更新日期：2005-01-01 00:00:00