Abstract：
:Lipid peroxidation increased both in the liver homogenates and in the hepatic mitochondrial fraction of bile duct ligated (BDL)-rats. Although mitochondrial superoxide dismutase (SOD) activity did not change in the liver, glutathione (GSH) levels and glutathione peroxidase (GSH-Px) activity decreased in hepatic mitochondrial fraction of BDL-rats as compared to sham-operated rats. In addition, GSH-Px and glutathione transferase (GST) activities decreased but SOD activity remained unchanged in the post-mitochondrial fraction of the liver from BDL-rats. However, erythrocyte lipid peroxide and GSH levels did not change in BDL-rats. In conclusion, our results show that the disturbance of oxidant-antioxidant balance especially in mitochondria may be responsible for cholestatic liver injury in BDL-rats.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Alptekin N,Mehmetçik G,Uysal M,Aykaç-toker Gdoi
10.1006/phrs.1997.0225subject
Has Abstractpub_date
1997-09-01 00:00:00pages
243-7issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(97)90225-5journal_volume
36pub_type
杂志文章abstract：:In hypothermic rats with acute hypertension induced by intravenous injection of adrenalin, regional changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indication. Evans blue albumin extravasation was determined as a macroscopic finding and a quantitative estimation with...
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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