Influence of profound hypothermia on the blood-brain barrier permeability during acute arterial hypertension.

abstract：:A bovine dopamine transporter (bDAT) cDNA was transfected into CV-1 cells, a cell line that lacks vesicular storage and release mechanisms. Using this cell line, the effects of neuroleptic drugs on DAT-mediated uptake and release of dopamine (DA) were examined. All of the neuroleptic drugs tested, inhibited DA uptakes...

journal_title：Pharmacological research

authors： Lee Sh,Oh Dy,Jung Sc,Kim Ym,Cho Hk,Koh Jk,Lee Ys

更新日期：1997-05-01 00:00:00

abstract：:The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

journal_title：Pharmacological research

authors： Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

更新日期：2018-03-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries. In the majority of cases, HEV causes a self-limiting hepatitis. GT3 and GT4 can be responsib...

journal_title：Pharmacological research

authors： De Winter BCM,Hesselink DA,Kamar N

更新日期：2018-04-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...

journal_title：Pharmacological research

authors： Koksel O,Yildirim C,Cinel L,Tamer L,Ozdulger A,Bastürk M,Degirmenci U,Kanik A,Cinel I

更新日期：2005-05-01 00:00:00

abstract：:To assess the potential role of vasoactive cardiac eicosanoids in the modulation of coronary flow, we measure thromboxane(TX)B2, 6-keto-prostaglandin(PG)F1 alpha, PGE2 and sulphido-peptide leukotrienes (LTC4, D4, E4) in the coronary effluent of isolated perfused rat heart in both baseline and post-ischaemic conditions...

journal_title：Pharmacological research

authors： Giannessi D,Lazzerini G,Sicari R,DeCaterina R

更新日期：1992-12-01 00:00:00

abstract：:The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succini...

journal_title：Pharmacological research

authors： Björkling F,Malaisse-Lagae F,Malaisse WJ

更新日期：1996-04-01 00:00:00

abstract：:Receptor concentrations for adrenaline, steroid hormones, PGF2alpha, LH and FSH were measured in the hypophysis and ovary of dairy cows with ovarian cysts and the results were compared with those of healthy animals. Significant modifications were found in all receptor concentrations, either between follicular and lute...

journal_title：Pharmacological research

authors： Odore R,Re G,Badino P,Donn A,Vigo D,Biolatti B,Girardi C

更新日期：1999-04-01 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...

journal_title：Pharmacological research

authors： Gambardella A,Labate A,Cifelli P,Ruffolo G,Mumoli L,Aronica E,Palma E

更新日期：2016-11-01 00:00:00

abstract：:Cancer immunotherapy has come of age with the advent of immune checkpoint inhibitors. In this article we review how agonists for receptors of the innate immune system, the Toll-like receptors and the RIG-I-like receptors, impact anticancer immune responses. Treatment with these agonists enhances the activity of antica...

journal_title：Pharmacological research

authors： Bourquin C,Pommier A,Hotz C

更新日期：2020-04-01 00:00:00

abstract：:Apoptosis of tissues may contribute to ischaemia-reperfusion injury. The aim of the present study was to determine whether administration of a colloid solution would prevent apoptosis after liver ischaemia-reperfusion. New Zealand rabbits, weighing 1.5-2 kg, were randomized to receive either 4% SG (20 ml kg (-1)h(-1) ...

journal_title：Pharmacological research

authors： Altunkan A,Aydin O,Ozer Z,Colak T,Bilgin E,Oral U

更新日期：2002-06-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer researchers have developed many agents to target TRAIL and some of these agents have entered clinical trials in oncology. Unfortunatel...

journal_title：Pharmacological research

authors： Dianat-Moghadam H,Heidarifard M,Mahari A,Shahgolzari M,Keshavarz M,Nouri M,Amoozgar Z

更新日期：2020-05-01 00:00:00

abstract：:The investigation was aimed at investigating whether the dopaminergic projection arriving at the nucleus septi lateralis (NSL) is involved in the facilitatory effect of vasopressin (AVP) on memory retrieval. The bilateral 6-OHDA lesions to the NSL were made in 20 male Wistar rats before testing the intracerebroventric...

journal_title：Pharmacological research

authors： Winnicka MM,Wiśniewski K

更新日期：1998-02-01 00:00:00

abstract：:Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate pr...

journal_title：Pharmacological research

authors： Oner-Iyidoğan Y,Oner P,Koçak H,Lama A,Gürdöl F,Bekpinar S,Unur N,Ozbek-Kir Z

更新日期：2005-10-01 00:00:00

abstract：:Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

journal_title：Pharmacological research

authors： Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

更新日期：2020-11-01 00:00:00

abstract：:There is evidence that hydrazine, a metabolite of isoniazid, plays an important role in the mechanism of isoniazid-induced hepatotoxicity. Hydrazine has been reported to be metabolised by NADPH cytochrome P-450 reductase (reductase) to reactive and potentially toxic intermediates. The present study was designed, using...

journal_title：Pharmacological research

authors： Sarich TC,Adams SP,Wright JM

更新日期：1998-09-01 00:00:00

abstract：:Osteopontin (OPN) is known as an active player in the progression of vascular remodeling diseases, however, the precise role in the proliferation of vascular smooth muscle cells (VSMC) is unclear. Thus, this study investigated the role of OPN in VSMC proliferation induced by 4-hydroxynonenal (HNE), and identified the ...

journal_title：Pharmacological research

authors： Lee SJ,Baek SE,Jang MA,Kim CD

更新日期：2016-06-01 00:00:00

abstract：:Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and...

journal_title：Pharmacological research

authors： Ávila-Román J,Talero E,de Los Reyes C,García-Mauriño S,Motilva V

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF THE RESEARCH:Overexpression of the human dimethylarginine dimethylaminohydrolase type 1 (hDDAH1) gene was reported to have beneficial cardiovascular effects in mice. To date, it is unclear whether these effects are related to enhanced metabolic clearance of asymmetric dimethylarginine (ADMA) and l-N(G)-mono-...

journal_title：Pharmacological research

authors： Schwedhelm E,von Leitner EC,Atzler D,Schmitz C,Jacobi J,Meinertz T,Münzel T,Baldus S,Cooke JP,Böger RH,Maas R,Sydow K

更新日期：2009-12-01 00:00:00

abstract：:The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...

journal_title：Pharmacological research

authors： Abo El Sooud K

更新日期：2003-10-01 00:00:00

abstract：:(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg-1, 30 min before the test, significantly decreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg-1) diminished the protective activity of diphenylhydantoin, phenobarbi...

journal_title：Pharmacological research

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1999-12-01 00:00:00

abstract：:Fish represent the oldest and most diverse classes of vertebrates, comprising around the 48% of the known member species in the subphylum Vertebrata. There are many scientific fields that use fish as models in research, including respiratory and cardiovascular research, cell culture, ecotoxicology, ageing, pharmacolog...

journal_title：Pharmacological research

authors： Bolis CL,Piccolella M,Dalla Valle AZ,Rankin JC

更新日期：2001-10-01 00:00:00

abstract：:Erdosteine was introduced in the market as a mucolytic agent for chronic pulmonary diseases more than 10 years ago. The drug contains two blocked sulphydryl groups one of which, after hepatic metabolization and opening of the thiolactone ring, becomes available both for the mucolytic and free radical scavenging and an...

journal_title：Pharmacological research

authors： Moretti M,Marchioni CF

更新日期：2007-04-01 00:00:00

abstract：:Moderate wine consumption has been shown to reduce cardiovascular (CV) risk, due to alcohol and polyphenolic compounds, such as resveratrol. We investigated the associations between total urinary resveratrol metabolites (TRMs) as biomarkers of wine and resveratrol consumption and CV risk factors in a large cross-secti...

journal_title：Pharmacological research

authors： Zamora-Ros R,Urpi-Sarda M,Lamuela-Raventós RM,Martínez-González MÁ,Salas-Salvadó J,Arós F,Fitó M,Lapetra J,Estruch R,Andres-Lacueva C,PREDIMED Study Investigators.

更新日期：2012-06-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are used widely for the treatment of acid-related disorders. Despite their excellent efficacy and tolerance, the pharmacodynamics and pharmacokinetics of PPIs are affected by each patient's CYP2C19 and gastric H+,K+-ATPase genotype. The aim of this review was to analyze the effect of gene...

journal_title：Pharmacological research

authors： Zhang HJ,Zhang XH,Liu J,Sun LN,Shen YW,Zhou C,Zhang HW,Xie LJ,Chen J,Liu Y,Wang YQ

更新日期：2020-02-01 00:00:00

abstract：:We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...

journal_title：Pharmacological research

authors： Villa V,Thellung S,Bajetto A,Gatta E,Robello M,Novelli F,Tasso B,Tonelli M,Florio T

更新日期：2016-11-01 00:00:00

abstract：:Breast cancer is a leading cause of morbidity and mortality in women. Both Epidemiological and experimental studies indicate a positive correlation between alcohol consumption and the risk of breast cancer. While alcohol exposure may promote the carcinogenesis or onset of breast cancer, it may as well enhance the prog...

journal_title：Pharmacological research

authors： Wang Y,Xu M,Ke ZJ,Luo J

更新日期：2017-01-01 00:00:00

abstract：:Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the presence of a δ subunit in the receptor complex. δ-Containing receptors respond to low ambient concentrations of GABA, or respond to spillover of GABA from the synapse, and give rise to tonic inhibitory currents. In ce...

journal_title：Pharmacological research

authors： Ahring PK,Bang LH,Jensen ML,Strøbæk D,Hartiadi LY,Chebib M,Absalom N

更新日期：2016-09-01 00:00:00

abstract：:Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over decades, only a few drugs were approved by Food and Drug Administration (FDA) and most ended in failure. The lessons learned have switched the strategy of drug discovery from designing highly selective ligands to a network pharm...

journal_title：Pharmacological research

authors： Huang L,Wang S,Ma F,Zhang Y,Peng Y,Xing C,Feng Y,Wang X,Peng Y

更新日期：2018-09-01 00:00:00

abstract：:One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessin...

journal_title：Pharmacological research

authors： Reis F,Tavares P,Teixeira F

更新日期：2000-02-01 00:00:00