Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier.

abstract：:Dyslipidemia and hyperglycemia are associated with an increased risk of ischemic cardiovascular disease. Positive effects of a nutraceutical combination comprising red yeast rice, berberine, policosanol, astaxanthin, coenzyme Q10 and folic acid (NComb) on plasma lipid and glucose levels have been reported in some but ...

journal_title：Pharmacological research

authors： Pirro M,Mannarino MR,Bianconi V,Simental-Mendía LE,Bagaglia F,Mannarino E,Sahebkar A

更新日期：2016-08-01 00:00:00

abstract：:The cytokine thymic stromal lymphopoietin (TSLP) is involved in the development and the progression of allergic diseases. It is mainly released by epithelial cells at barriers such as skin and gut in response to danger signals. Overexpression of TSLP in keratinocytes (KC) can provoke the development of a type 2 inflam...

journal_title：Pharmacological research

authors： Schaper K,Rossbach K,Köther B,Stark H,Kietzmann M,Werfel T,Gutzmer R

更新日期：2016-11-01 00:00:00

abstract：:Central nervous system (CNS) drug development faces significant difficulties that translate into high rates of failure and lack of innovation. The pathophysiology of neurological and psychiatric disorders often results in the breakdown of blood-CNS barriers, disturbing the CNS microenvironment and worsening disease pr...

journal_title：Pharmacological research

authors： Bicker J,Alves G,Fonseca C,Falcão A,Fortuna A

更新日期：2020-12-01 00:00:00

abstract：:A favourable option to management symptoms during menopausal transition is menopausal hormone therapy (MHT) but relation among MHT and risk of melanoma is controversial. This study aims to identify, analyse and present the evidence surrounding post-menopausal exogenous hormone therapy and the risk for melanoma in wome...

journal_title：Pharmacological research

authors： Tang X,Zhang H,Cui Y,Wang L,Wang Z,Zhang Y,Huo J,Cai J,Rinaldi G,Bhagavathula AS,Xiaopeng Y

更新日期：2020-10-01 00:00:00

abstract：:Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptome analysis, we comp...

journal_title：Pharmacological research

authors： Chen Y,Brooks MJ,Gieser L,Swaroop A,Palczewski K

更新日期：2017-01-01 00:00:00

abstract：:In 1996, Dr. Costa was invited by Prof. Boris Astrachan, Chairman of the Department of Psychiatry at the University of Illinois at Chicago, to direct the research of the "Psychiatric Institute, Department of Psychiatry, School of Medicine, at the University of Illinois at Chicago." He was asked to develop a seminal re...

journal_title：Pharmacological research

authors： Guidotti A,Grayson DR

更新日期：2011-10-01 00:00:00

abstract：:The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin ...

journal_title：Pharmacological research

authors： Sautebin L,Carnuccio R,Ialenti A,Di Rosa M

更新日期：1992-01-01 00:00:00

abstract：:Quiescent hepatic stellate cell (HSC) activation and subsequent conversion into myofibroblasts is the central event in hepatic fibrosis pathogenesis. Epithelial-mesenchymal transition (EMT), another vital participant in liver fibrosis, has the potential to initiate HSC activation, which promotes abundant myofibroblast...

journal_title：Pharmacological research

authors： Zhao H,Wang Z,Tang F,Zhao Y,Feng D,Li Y,Hu Y,Wang C,Zhou J,Tian X,Yao J

更新日期：2018-02-01 00:00:00

abstract：:The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization (WHO), and its harm degree is defined as a global "pandemic". At present, the efforts of various countries focus on the rapid di...

journal_title：Pharmacological research

authors： Huang F,Li Y,Leung EL,Liu X,Liu K,Wang Q,Lan Y,Li X,Yu H,Cui L,Luo H,Luo L

更新日期：2020-08-01 00:00:00

abstract：:Beta-endorphin/beta-lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain p...

journal_title：Pharmacological research

authors： Salar G,Alessio L,Govoni S,Battaini F,Iob I,Goss I,Trabucchi M

更新日期：1991-02-01 00:00:00

abstract：:The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

journal_title：Pharmacological research

authors： Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

更新日期：1999-11-01 00:00:00

abstract：:Osteoporosis caused by aging and menopause had become an emerging threat to human health. The reduction of osteoblast differentiation has been considered to be an essential cause of osteoporosis. Osteoblast differentiation could be regulated by LncRNAs, and increasing evidences have proved that LncRNAs may be adopted ...

journal_title：Pharmacological research

authors： Yin C,Tian Y,Yu Y,Li D,Miao Z,Su P,Zhao Y,Wang X,Pei J,Zhang K,Qian A

更新日期：2021-01-01 00:00:00

abstract：:Mast cells take part of armamentarium immunologic for host defense against parasitic and bacterial infections. They are derived from bone marrow progenitors and can be activated by immunological and chemical stimuli in order to get its degranulation. The activation of mast cells generates a signalling cascade leaded t...

journal_title：Pharmacological research

authors： Maldonado MD,Mora-Santos M,Naji L,Carrascosa-Salmoral MP,Naranjo MC,Calvo JR

更新日期：2010-09-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

journal_title：Pharmacological research

authors： Shimomura Y,Kitaura Y

更新日期：2018-07-01 00:00:00

abstract：:Potential risks of cyclohexanol (CH) and cyclohexanediol (CHD) isomers, which are the metabolites derived from cilexetil ester side-chain of several prodrugs such as antibiotics (e.g. cefotiam hexetil) and an antihypertensive agent (candesartan cilexetil), were examined in beagles that were made congestive heart failu...

journal_title：Pharmacological research

authors： Okunishi H,Shimoura K,Wang DQ,Kakizoe E

更新日期：2002-10-01 00:00:00

abstract：:The intestinal barrier function depends on an adequate response to pathogens by the epithelium. Toll-like receptor 3 (TLR-3) recognizes double-stranded RNA, a virus-associated molecular pattern. Activation of TLR-3 with Poly(I:C), a synthetic agonist, modulates tissue repair and permeability in other epithelia; howeve...

journal_title：Pharmacological research

authors： Moyano-Porcile V,Olavarría-Ramírez L,González-Arancibia C,Bravo JA,Julio-Pieper M

更新日期：2015-11-01 00:00:00

abstract：:The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

journal_title：Pharmacological research

authors： Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

更新日期：2018-03-01 00:00:00

abstract：:The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyruvic acid, succinic acid and glutamic acid. The meglitinide a...

journal_title：Pharmacological research

authors： Bakkali Nadi A,Zhang TM,Malaisse WJ

更新日期：1996-03-01 00:00:00

abstract：:Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase involved in several cellular processes. In recent years, SHP2 has been the focus of significant attention in human diseases, particular in cancer. Several studies have shown that SHP2 plays an important role in regulating immune cel...

journal_title：Pharmacological research

authors： Liu Q,Qu J,Zhao M,Xu Q,Sun Y

更新日期：2020-02-01 00:00:00

abstract：:The isolated heart is deservedly one of the most popular experimental models in cardiovascular research, both in terms of cost and the quality and quantity of data it provides. However, it is a deceptively simple model, capable of throwing many problems in the path of the inexperienced or unwary perfuser. The followin...

journal_title：Pharmacological research

authors： Sutherland FJ,Hearse DJ

更新日期：2000-06-01 00:00:00

abstract：:Psoriasis is a lifelong, chronic and immune-mediated skin disease affecting approximately 1-3% of the Caucasian population. Pathogenesis of psoriasis is associated with an increased expression of tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a pro-inflammatory cytokine and important mediator of cachexia. Anti-...

journal_title：Pharmacological research

authors： Saraceno R,Schipani C,Mazzotta A,Esposito M,Di Renzo L,De Lorenzo A,Chimenti S

更新日期：2008-04-01 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between early treatment with Qingfei Paidu decoction (QFPDD) and favorable clinical outcomes. In this retrospecti...

journal_title：Pharmacological research

authors： Shi N,Liu B,Liang N,Ma Y,Ge Y,Yi H,Wo H,Gu H,Kuang Y,Tang S,Zhao Y,Tong L,Liu S,Zhao C,Chen R,Bai W,Fan Y,Shi Z,Li L,Liu J,Gu H,Zhi Y,Wang Z,Li Y,Li H,Wang J,Jiao L,Tian Y,Xiong Y,Huo R,Zhang X

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Overexpression of heat shock proteins (Hsps) is associated to myocardial protection and it has been suggested that they could be a marker of cardiac preservation in conditions such as extracorporeal circulation. Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the...

journal_title：Pharmacological research

authors： Giannessi D,Caselli C,Vitale RL,Crucean A,Murzi B,Del Ry S,Vanini V,Biagini A

更新日期：2003-11-01 00:00:00

abstract：:Perfusion of all mammalian heart muscle except hamster with Ca(2+)-free Tyrode and thereafter reperfusion with normal Tyrode causes irreversible damage, the calcium paradox. Our study aims at deciphering the role of creatine kinase, high energy phosphates and Ca(2+)influx in the genesis of myocardial injury in the rat...

journal_title：Pharmacological research

authors： Ray M,Roy R,Chowdhury PD,Srivastava S,Dubey MP

更新日期：2000-03-01 00:00:00

abstract：:Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are natu...

journal_title：Pharmacological research

authors： Lim DW,Park J,Jung J,Kim SH,Um MY,Yoon M,Kim YT,Han D,Lee C,Lee J

更新日期：2020-11-01 00:00:00

abstract：:Nanotechnology applications in medicine, termed as nanomedicine, have introduced a number of nanoparticles of variable chemistry and architecture for cancer imaging and treatment. Nanotechnology involves engineering multifunctional devices with dimensions at the nanoscale, similar dimensions as those of large biologic...

journal_title：Pharmacological research

authors： Wang M,Thanou M

更新日期：2010-08-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:Reproductive dysfunction in the female diabetic rat is associated with impaired hypothalamic-hypophyseal system, anovulation, insufficiency of ovarian steroidogenesis and spontaneous failure of pregnancy. Formation of decidua, the highly modified endometrium of pregnancy and pseudopregnancy could only be achieved when...

journal_title：Pharmacological research

authors： Zakaria R,Ismail Z,Chatterjee A

更新日期：2000-08-01 00:00:00

abstract：:Many data suggest an involvement of toxic oxygen radicals in the termination of endurance to muscle fatigue. Being reduced glutathione (GSH), an efficient intracellular physiological antioxidant, experiments have been performed to discover whether exogenous GSH modifies endurance to exhaustive swimming in mice. GSH wa...

journal_title：Pharmacological research

authors： Novelli GP,Falsini S,Bracciotti G

更新日期：1991-02-01 00:00:00

abstract：:6-Mercaptopurine is a cytotoxic and immunosuppressant drug. The use of this drug is limited due to its poor bioavailability and short plasma half-life. In order to nullify these drawbacks, 6-mercaptopurine-chitosan nanoparticles (6-MP-CNPs) were prepared and evaluated to study the influence of preparation conditions o...

journal_title：Pharmacological research

authors： Kumar GP,Sanganal JS,Phani AR,Manohara C,Tripathi SM,Raghavendra HL,Janardhana PB,Amaresha S,Swamy KB,Prasad RG

更新日期：2015-10-01 00:00:00