Abstract：
:The review emphasizes the role of NGF, the most representative member of the neurotrophins family, in cardiac physiopathology with a particular focus on healing and sprouting processes occurring after tissue damage. Cardiac and circulating NGF levels dramatically increase following myocardial injury (MI). A very early rise of this neurotrophin is indeed observed soon after MI (hours). Such a rise may lead to sympathetic nerve sprouting which may underlie the later genesis of arrhythmias but may also favor the healing process. At later times (months after), when heart failure develops, the opposite is detected and NGF tissue levels are below the normal range, an event that may in turn participate to defective innervation and cardiac failure. Through a careful analysis of preclinical and clinical studies, this review proposes that time is the key variable when studying these opposite changes in NGF expression observed following MI and attempting to interpret and correlate them with cardiac physiopathology. The examination of the results leads to the speculation that NGF modulation may be a pharmacological target for interventions in specific stages of heart dysfunction following MI.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Govoni S,Pascale A,Amadio M,Calvillo L,D'Elia E,Cereda C,Fantucci P,Ceroni M,Vanoli Edoi
10.1016/j.phrs.2010.12.017subject
Has Abstractpub_date
2011-04-01 00:00:00pages
266-77issue
4eissn
1043-6618issn
1096-1186pii
S1043-6618(10)00254-9journal_volume
63pub_type
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