Abstract:
:Endocannabinoids are part of a bioactive lipid signaling system, not only in the central nervous system but also in various peripheral organs. Accumulating evidence implicates dysregulation of the endocannabinoid system (ECS) in the pathogenesis of various cardiovascular diseases, including hypertension, atherosclerosis, myocardial infarction, hemorrhagic or septic shock, heart failure and cardiovascular complications of liver cirrhosis. Even though the benefit of chronic cannabinoid 1 (CB1) receptor blockade with the currently available compounds may not outweigh the risks in chronic conditions such as obesity, modulation of the ECS may hold great therapeutic promise in various cardiovascular conditions/disorders. In this review we will discuss recent advances in understanding the role of CB1 receptors and endocannabinoids in the regulation of cardiac function in cirrhotic cardiomyopathy and in doxorubicin-induced heart failure.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Bátkai S,Pacher Pdoi
10.1016/j.phrs.2009.04.003subject
Has Abstractpub_date
2009-08-01 00:00:00pages
99-106issue
2eissn
1043-6618issn
1096-1186pii
S1043-6618(09)00112-1journal_volume
60pub_type
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