Microalgae-derived oxylipins decrease inflammatory mediators by regulating the subcellular location of NFκB and PPAR-γ.

abstract：:Kindling represents an accepted model of human epileptogenesis. Furthermore, it has been demonstrated that kindled rats show a diminished learning performance in an active avoidance task. In our study we administered different nootropic drugs to kindled rats to test their effects on learning a two-way active avoidance...

journal_title：Pharmacological research

authors： Becker A,Grecksch G

更新日期：1995-09-01 00:00:00

abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

journal_title：Pharmacological research

authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

更新日期：2007-12-01 00:00:00

abstract：:Ginseng is one of the most popular herbal remedies. Studies were performed in anaesthetized rats to examine the effect of ginseng on bile secretion. Male Sprague-Dawley rats were anaesthetized with intraperitoneal (i.p.) urethane (1.25 g kg(-1)) and equipped with biliary cannulas inserted into the bile duct through th...

journal_title：Pharmacological research

authors： Salam OM,Nada SA,Arbid MS

更新日期：2002-04-01 00:00:00

abstract：:Receptor concentrations for adrenaline, steroid hormones, PGF2alpha, LH and FSH were measured in the hypophysis and ovary of dairy cows with ovarian cysts and the results were compared with those of healthy animals. Significant modifications were found in all receptor concentrations, either between follicular and lute...

journal_title：Pharmacological research

authors： Odore R,Re G,Badino P,Donn A,Vigo D,Biolatti B,Girardi C

更新日期：1999-04-01 00:00:00

abstract：:Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the presence of a δ subunit in the receptor complex. δ-Containing receptors respond to low ambient concentrations of GABA, or respond to spillover of GABA from the synapse, and give rise to tonic inhibitory currents. In ce...

journal_title：Pharmacological research

authors： Ahring PK,Bang LH,Jensen ML,Strøbæk D,Hartiadi LY,Chebib M,Absalom N

更新日期：2016-09-01 00:00:00

abstract：:Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell ...

journal_title：Pharmacological research

authors： Westermeier F,Bustamante M,Pavez M,García L,Chiong M,Ocaranza MP,Lavandero S

更新日期：2015-11-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:Kidney injury is one of the main complications of obstructive jaundice (OJ) and its pathogenesis has not been clarified. As an independent risk factor for OJ associated with significant morbidity and mortality, it can be mainly divided into two types of morphological injury and functional injury. We called these dysfu...

journal_title：Pharmacological research

authors： Liu J,Qu J,Chen H,Ge P,Jiang Y,Xu C,Chen H,Shang D,Zhang G

更新日期：2021-01-01 00:00:00

abstract：:The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties ...

journal_title：Pharmacological research

authors： Perreault M,Maltais R,Kenmogne LC,Létourneau D,LeHoux JG,Gobeil S,Poirier D

更新日期：2018-02-01 00:00:00

abstract：:The most frequent cause of mortality and morbidity in industrialized countries is coronary artery disease (CAD), which in Europe alone is responsible for around two million deaths per year. In 2001 it accounted for about 260,000 hospital discharges in Italy. The costs of CAD treatment in Italy--which were borne by the...

journal_title：Pharmacological research

authors： De Portu S,Menditto E,Scalone L,Bustacchini S,Cricelli C,Mantovani LG

更新日期：2006-08-01 00:00:00

abstract：:The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an inc...

journal_title：Pharmacological research

authors： Pini A,Obara I,Battell E,Chazot PL,Rosa AC

更新日期：2016-09-01 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...

journal_title：Pharmacological research

authors： Gambardella A,Labate A,Cifelli P,Ruffolo G,Mumoli L,Aronica E,Palma E

更新日期：2016-11-01 00:00:00

abstract：:Diabetes is a chronic metabolic disease characterized by hyperglycemia and several associated biochemical abnormalities. Diabetes leads to multiorgan complications that collectively reduce life expectancy. Hematopoietic stem cells (HSCs) are nested within bone marrow (BM) niches whence they can be mobilized to the per...

journal_title：Pharmacological research

authors： Albiero M,Fadini GP

更新日期：2018-09-01 00:00:00

abstract：:Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

journal_title：Pharmacological research

authors： Furlanut M,Benetello P

更新日期：1990-01-01 00:00:00

abstract：:Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Foll...

journal_title：Pharmacological research

authors： Panini R,Vandelli MA,Forni F,Pradelli JM,Salvioli G

更新日期：1995-03-01 00:00:00

abstract：:In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sen...

journal_title：Pharmacological research

authors： Kounenis G,Koutsoviti-Papadopoulou M,Elezoglou V

更新日期：1995-06-01 00:00:00

abstract：:The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is n...

journal_title：Pharmacological research

authors： Fleming I

更新日期：2004-06-01 00:00:00

abstract：:Diarrhea is a common side effect experienced by cancer patients undergoing clinical chemotherapy, such as with 5-fluorouracil (5-FU). However, the precise mechanisms underlying 5-FU-induced diarrhea remain unclear. In the present study, we examined the role of neutrophil in 5-FU-induced diarrhea. Mice were given 5-FU ...

journal_title：Pharmacological research

authors： Sakai H,Sagara A,Matsumoto K,Jo A,Hirosaki A,Takase K,Sugiyama R,Sato K,Ikegami D,Horie S,Matoba M,Narita M

更新日期：2014-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

journal_title：Pharmacological research

authors： Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

更新日期：2020-12-08 00:00:00

abstract：:Oxidative stress is an important contributor to the risk of chronic diseases. Dietary guidelines recommend increased consumption of fruits and vegetables to combat the incidence of human diseases such as cancer, cardiovascular disease, osteoporosis and diabetes. Fruits and vegetables are good sources of antioxidant ph...

journal_title：Pharmacological research

authors： Rao AV,Rao LG

更新日期：2007-03-01 00:00:00

abstract：:Secretion of matrix metalloproteinases (MMPs) by macrophages and smooth muscle cells (SMC) may impair atherosclerotic cap integrity leading to atherosclerosis complications. Selective estrogen receptor modulators (SERMs) have favourable impact on plasma lipid levels, but their role in the prevention of atherosclerosis...

journal_title：Pharmacological research

authors： Bellosta S,Baetta R,Canavesi M,Comparato C,Granata A,Monetti M,Cairoli F,Eberini I,Puglisi L,Corsini A

更新日期：2007-08-01 00:00:00

abstract：:Evodiae fructus is a widely used herbal drug in traditional Chinese medicine. Evodia extract was found to inhibit hERG channels. The aim of the current study was to identify hERG inhibitors in Evodia extract and to investigate their potential proarrhythmic effects. Dehydroevodiamine (DHE) and hortiamine were identifie...

journal_title：Pharmacological research

authors： Baburin I,Varkevisser R,Schramm A,Saxena P,Beyl S,Szkokan P,Linder T,Stary-Weinzinger A,van der Heyden MAG,Houtman M,Takanari H,Jonsson M,Beekman JHD,Hamburger M,Vos MA,Hering S

更新日期：2018-05-01 00:00:00

abstract：:Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our...

journal_title：Pharmacological research

authors： Liu J,Yue S,Yang Z,Feng W,Meng X,Wang A,Peng C,Wang C,Yan D

更新日期：2018-08-01 00:00:00

abstract：:In previous studies we observed an enhanced anti-inflammatory activity of MPEG-SOD derivatives in acute inflammation in rat. To assess the activity in chronic inflammation we tested the compound with longer half-life (MPEG-SOD 18) in complete adjuvant arthritis in rat. According to the prophylactic schedule of treatme...

journal_title：Pharmacological research

authors： Conforti A,Caliceti P,Sartore L,Schiavon O,Veronese F,Velo GP

更新日期：1991-01-01 00:00:00

abstract：:In this investigation we have examined the effects of indomethacin, an inhibitor of the cyclooxygenase pathway of arachidonic acid, upon the kinetics of the release of tumour necrosis factor alpha (TNF) and of the expression of TNF gene by lipopolysaccharide (LPS)-stimulated human blood monocytes (BM). Following stimu...

journal_title：Pharmacological research

authors： Spatafora M,Chiappara G,D'Amico D,Volpes D,Melis M,Pace E,Merendino A

更新日期：1991-04-01 00:00:00

abstract：:To minimize irreversible brain injury after acute ischemic stroke (AIS), the time to treatment (i.e., treatment delay) should be minimized. However, thus far, all cytoprotective clinical trials have failed. Analysis of literature identified short treatment durations (≤72 h) as a common motif among completed cytoprotec...

journal_title：Pharmacological research

authors： Gaidhani N,Uteshev VV

更新日期：2018-10-01 00:00:00

abstract：:There is evidence that hydrazine, a metabolite of isoniazid, plays an important role in the mechanism of isoniazid-induced hepatotoxicity. Hydrazine has been reported to be metabolised by NADPH cytochrome P-450 reductase (reductase) to reactive and potentially toxic intermediates. The present study was designed, using...

journal_title：Pharmacological research

authors： Sarich TC,Adams SP,Wright JM

更新日期：1998-09-01 00:00:00

abstract：:The aim of the present pilot study was to characterise the renal elimination of betalains after consumption of red beet juice (RBJ). Six healthy, non-smoking female volunteers were given a single oral dose of either 500 mL of a commercial RBJ containing 362.7 mg of betalains and 500 mL of tap water, respectively, in a...

journal_title：Pharmacological research

authors： Frank T,Stintzing FC,Carle R,Bitsch I,Quaas D,Strass G,Bitsch R,Netzel M

更新日期：2005-10-01 00:00:00

abstract：:Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and medicinal plants. In the last decade, a plethora of studies on the pharmacological activities of lupeol have been conducted and have demonstrated that lupeol possesses an extensive range of pharmacological activities such as antic...

journal_title：Pharmacological research

authors： Liu K,Zhang X,Xie L,Deng M,Chen H,Song J,Long J,Li X,Luo J

更新日期：2020-12-11 00:00:00

abstract：:Our goal was to establish the requirement of β3 adrenoceptor (β3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and β3Adr knockout (KO) male mice fed with a standard diet or a high-fat diet (HFD/16 weeks) treated or not with GT (0.5 g/kg of body weig...

journal_title：Pharmacological research

authors： Sousa-Filho CPB,Faria HOF,Esposito JC,Melo A,Ribeiro MO,Otton R

更新日期：2020-09-01 00:00:00