DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924.

abstract：:Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

journal_title：Pharmacological research

authors： Mougenot N,Médiani O,Lechat P

更新日期：2005-04-01 00:00:00

abstract：:Local microcirculatory dysfunction within the pancreatic gland might be an important factor in the conversion of oedematous to necrotizing pancreatitis. Therapeutic agents, improving the pancreatic blood flow, might be valuable in acute pancreatitis treatment. An influence of nitric oxide, heparin and procaine treatme...

journal_title：Pharmacological research

authors： Dobosz M,Hac S,Mionskowska L,Dobrowolski S,Wajda Z

更新日期：1997-08-01 00:00:00

abstract：:The interaction of mianserin with ethanol in central nervous system (CNS) was investigated. Mianserin was administered at a single dose of 5 or 20 mgkg(-1) i.p. or as daily injections in a dose of 2.5 mgkg(-1) given for 14 days. The influence of mianserin on acute ethanol toxicity (LD(50)), on ED(50) of ethanol in rot...

journal_title：Pharmacological research

authors： Pietrzak B,Kubik-Bogucka E

更新日期：2002-07-01 00:00:00

abstract：:A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer p...

journal_title：Pharmacological research

authors： Kim DH,Khan H,Ullah H,Hassan STS,Šmejkal K,Efferth T,Mahomoodally MF,Xu S,Habtemariam S,Filosa R,Lagoa R,Rengasamy KR

更新日期：2019-09-01 00:00:00

abstract：:Several studies have demonstrated that any beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins), of which simvastatin (Merck Sharp & Dohme) is an example, on coronary events are linked to their hypocholesterolemic properties. The in vivo effects of simvastatin treatment ...

journal_title：Pharmacological research

authors： Pioruńska-Stolzmann M,Pioruńska-Mikołajczak A

更新日期：2001-04-01 00:00:00

abstract：:(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg-1, 30 min before the test, significantly decreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg-1) diminished the protective activity of diphenylhydantoin, phenobarbi...

journal_title：Pharmacological research

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Thymidylate synthase (TS) expression levels appear to be related to response to 5-fluorouracil-(5-FU)-based chemotherapy in colorectal cancer (CRC) patients. Three polymorphisms have been proposed as modulators of TS expression: a tandemly repeated sequence (2R/3R) in the 5' UTR, a SNP (G>C) w...

journal_title：Pharmacological research

authors： Vignoli M,Nobili S,Napoli C,Putignano AL,Morganti M,Papi L,Valanzano R,Cianchi F,Tonelli F,Mazzei T,Mini E,Genuardi M

更新日期：2011-09-01 00:00:00

abstract：:Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

journal_title：Pharmacological research

authors： Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

更新日期：2005-06-01 00:00:00

abstract：:The available studies have reported the benefits of statins on all-cause and cardiovascular mortality in chronic kidney disease (CKD) patients. However studies in end-stage renal disease patients on dialysis yielded conflicting results. Therefore, we performed a meta-analysis and provide the most reliable trial data t...

journal_title：Pharmacological research

authors： Barylski M,Nikfar S,Mikhailidis DP,Toth PP,Salari P,Ray KK,Pencina MJ,Rizzo M,Rysz J,Abdollahi M,Nicholls SJ,Banach M,Lipid and Blood Pressure Meta-Analysis Collaboration Group.

更新日期：2013-06-01 00:00:00

abstract：:Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow (P. notoginseng) is a highly valued Chinese materia medica having a hemostatic effect and mainly used for the treatment of trauma and ischemic cardiovascular diseases. Stringent growth requirements, weak resistance to insect pests and plant diseases, arsenic contami...

journal_title：Pharmacological research

authors： Yang BR,Yuen SC,Fan GY,Cong WH,Leung SW,Lee SM

更新日期：2018-08-01 00:00:00

abstract：:Flt3 is expressed by early myeloid and lymphoid progenitor cells and it regulates the proliferation and differentiation of hematopoietic cells. Flt3 is activated by the Flt3 ligand, the monomeric form of which is a polypeptide of about 200 amino acid residues. Both membrane-associated and soluble Flt3 ligands, which a...

journal_title：Pharmacological research

authors： Roskoski R Jr

更新日期：2020-05-01 00:00:00

abstract：:Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. In visceral obese subjects, signal transducer and activator of the transcription 3 (STAT3) in adipocy...

journal_title：Pharmacological research

authors： Su T,Huang C,Yang C,Jiang T,Su J,Chen M,Fatima S,Gong R,Hu X,Bian Z,Liu Z,Kwan HY

更新日期：2020-02-01 00:00:00

abstract：:Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...

journal_title：Pharmacological research

authors： Mansour MA,El-Kashef HA,Al-Shabanah OA

更新日期：1999-03-01 00:00:00

abstract：:Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated ...

journal_title：Pharmacological research

authors： Soriano A,Nesher G,Shoenfeld Y

更新日期：2015-02-01 00:00:00

abstract：:At the moment, little treatment options are available for Duchenne muscular dystrophy (DMD). The absence of the dystrophin protein leads to a complex cascade of pathogenic events in myofibres, including chronic inflammation and oxidative stress as well as altered metabolism. The attention towards dietary supplements i...

journal_title：Pharmacological research

authors： Boccanegra B,Verhaart IEC,Cappellari O,Vroom E,De Luca A

更新日期：2020-08-01 00:00:00

abstract：:Derivatization of phenothiazine (PTZ, 1) has been a commonly used method to develop drugs with various pharmacological properties. In the present study, a series of PTZ derivatives 1-11 were investigated on the inhibition of the cloned α7 subunit of the human nicotinic acetylcholine receptor (α7-nAChR) expressed in Xe...

journal_title：Pharmacological research

authors： Sadek B,Ashoor A,Al Mansouri A,Lorke DE,Nurulain SM,Petroianu G,Wainwright M,Oz M

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...

journal_title：Pharmacological research

authors： Korolkiewicz RP,Tashima K,Fujita A,Kato S,Takeuchi K

更新日期：2000-02-01 00:00:00

abstract：:Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

journal_title：Pharmacological research

authors： Furlanut M,Benetello P

更新日期：1990-01-01 00:00:00

abstract：:The antiepileptic drug vigabatrin (GVG) is known to decrease significantly the serum concentration of concurrently administered phenytoin (PHT) in epileptic patients. To assess a possible mechanism for this interaction, the effect of GVG on the intestinal absorption of PHT was investigated by means of circulation expe...

journal_title：Pharmacological research

authors： Tonini M,Gatti G,Manzo L,Olibet G,Coccini T,Perucca E

更新日期：1992-09-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

journal_title：Pharmacological research

authors： Zhu Y,Zhu C,Yang H,Deng J,Fan D

更新日期：2020-05-01 00:00:00

abstract：:In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335...

journal_title：Pharmacological research

authors： Singh R,Nath A,Gupta PP,Shulka M,Khare SK,Kundu B

更新日期：1998-05-01 00:00:00

abstract：:It is well known that type 2 diabetes mellitus is frequently associated with vascular dysfunction and an elevated systemic blood pressure, yet the underlying mechanisms are not completely understood. We previously reported that in mesenteric arteries from established type 2 diabetic Otsuka Long-Evans Tokushima fatty (...

journal_title：Pharmacological research

authors： Matsumoto T,Ishida K,Nakayama N,Taguchi K,Kobayashi T,Kamata K

更新日期：2010-09-01 00:00:00

abstract：:Cosmetics are largely diffused substances topically applied to wash, to perfume or to improve the look, nevertheless the number of reported adverse reactions is very low, probably because of underreporting. This could be due to self-diagnosis and self-medication that is common in the presence of not severe reactions. ...

journal_title：Pharmacological research

authors： Di Giovanni C,Arcoraci V,Gambardella L,Sautebin L

更新日期：2006-01-01 00:00:00

abstract：:Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggest that statins have additional properties such as endothelial protection via action o...

journal_title：Pharmacological research

authors： Malfitano AM,Marasco G,Proto MC,Laezza C,Gazzerro P,Bifulco M

更新日期：2014-10-01 00:00:00

abstract：:Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects...

journal_title：Pharmacological research

authors： Garbarino VR,Santos TA,Nelson AR,Zhang WQ,Smolik CM,Javors MA,Daws LC,Gould GG

更新日期：2019-02-01 00:00:00

abstract：:The transparent bodies of see-through medaka fish has led to their use as models for in vivo cell and tissue imaging. However, these fish may also prove useful as models for pathological processes. Accumulating reports show that pathology in fish is similar to that in mammals, including humans. In this study, patholog...

journal_title：Pharmacological research

authors： Kawasaki T,Saito K,Deguchi T,Fujimori K,Tadokoro M,Yuba S,Ohgushi H,Kawarabayasi Y

更新日期：2008-11-01 00:00:00

abstract：:In the present study, hyperglycaemia was induced by intraperitoneal injection of streptozotocin (65 mg/kg). Treatment with glibenclamide (GB) in a dose of 0.45 or 0.9 mg/kg significantly decreased plasma glucose level in a dose-related manner. Administration of nadolol (ND) in a dose of 5 or 10 mg/kg did not affect pl...

journal_title：Pharmacological research

authors： Abdel Aziz AH,Moustafa AM,Abd Ellah MF,el-Mazar MA

更新日期：1996-07-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer in women, and the second most frequent cause of cancer-related deaths in women worldwide. It is a heterogeneous disease composed of multiple subtypes with distinct morphologies and clinical implications. Quantitative systems pharmacology (QSP) is an emerging discipline brid...

journal_title：Pharmacological research

authors： Fleisher B,Brown AN,Ait-Oudhia S

更新日期：2017-10-01 00:00:00

abstract：:Alzheimer's disease is the fourth largest cause of death for people over 65 years of age. Dementia of Alzheimer's type is the commonest form of dementia, the other two forms being vascular dementia and mixed dementia. At present, the therapy of Alzheimer's disease is aimed at improving both, cognitive and behavioural ...

journal_title：Pharmacological research

authors： Sonkusare SK,Kaul CL,Ramarao P

更新日期：2005-01-01 00:00:00

abstract：:When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influen...

journal_title：Pharmacological research

authors： Ferland DJ,Watts SW

更新日期：2015-09-01 00:00:00