Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy--a meta-analysis of 11 randomized controlled trials involving 21,295 participants.

abstract：:This paper discusses the discovery of ligands for orphan receptors and the identification of the natural endogenous ligands for those receptors in physiology. The central thesis is that orphan seven transmembrane receptors (7TMRs) are allosteric conduits of chemical information exchange from extracellular ligands to i...

journal_title：Pharmacological research

authors： Kenakin TP

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present pilot study was to characterise the renal elimination of betalains after consumption of red beet juice (RBJ). Six healthy, non-smoking female volunteers were given a single oral dose of either 500 mL of a commercial RBJ containing 362.7 mg of betalains and 500 mL of tap water, respectively, in a...

journal_title：Pharmacological research

authors： Frank T,Stintzing FC,Carle R,Bitsch I,Quaas D,Strass G,Bitsch R,Netzel M

更新日期：2005-10-01 00:00:00

abstract：:Diabetes mellitus is associated with both microvascular and macrovascular complications, which can result in visceral aneurysms as for example splenic artery aneurysms: in their management, an endovascular treatment, less invasive than surgery, is generally preferred. Endovascular treatment of splenic artery aneurysms...

journal_title：Pharmacological research

authors： Venturini M,Marra P,Colarieti A,Agostini G,Lanza C,Augello L,Gusmini S,Salvioni M,Melissano G,Fiorina P,Chiesa R,De Cobelli F,Del Maschio A

更新日期：2018-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short single-stranded RNAs that have pivotal roles in disease pathophysiology through transcriptional and translational modulation of important genes. It has been implicated in the development of many diseases, such as stroke, cardiovascular conditions, cancers and inflammatory airway diseases. ...

journal_title：Pharmacological research

authors： Tan BWQ,Sim WL,Cheong JK,Kuan WS,Tran T,Lim HF

更新日期：2020-10-01 00:00:00

abstract：:In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted a...

journal_title：Pharmacological research

authors： Pistollato F,Forbes-Hernández TY,Calderón Iglesias R,Ruiz R,Elexpuru Zabaleta M,Cianciosi D,Giampieri F,Battino M

更新日期：2020-02-01 00:00:00

abstract：:In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining. Moreover, the relationship between Bcl-2, iNOS expression, and serum nitrate (NO(3)(-)) ...

journal_title：Pharmacological research

authors： Cinel I,Buyukafsar K,Cinel L,Polat A,Atici S,Tamer L,Oral U

更新日期：2002-08-01 00:00:00

abstract：:Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia (CML). In the present study, we conducted a systematic review and meta-analysis of published studies to estimate the impac...

journal_title：Pharmacological research

authors： Cargnin S,Ravegnini G,Soverini S,Angelini S,Terrazzino S

更新日期：2018-05-01 00:00:00

abstract：:In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABA(A)receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [(3)H]MK-801 binding, and the GABA(A)receptor bindings we...

journal_title：Pharmacological research

authors： Kim HS,Hwang SL,Nah SY,Oh S

更新日期：2001-05-01 00:00:00

abstract：:It has demonstrated that carteolol can increase the endothelium-dependent vasodilation induced by alpha-2 adrenergic agonist. In order to evaluate the effect of carteolol, and to clarify the mechanism, we examined the effects of 10 microM carteolol on the vasodilation induced by increasing doses (10(-7)-10(-4) M) of c...

journal_title：Pharmacological research

authors： Ito M,Fukuda N,Izumi Y,Watanabe Y,Watanabe M,Soma M,Kanmatsuse K

更新日期：1995-05-01 00:00:00

abstract：:Myriocin, a potent inhibitor of serine palmitoyltransferase (SPT), has been shown to reduce plasma sphingolipids, cholesterol and triglycerides in hyperlipidemic apolipoprotein E knockout (apoE KO) mice. We hypothesized that the inhibition of sphingolipid biosynthesis modulates the composition of atherosclerotic plaqu...

journal_title：Pharmacological research

authors： Park TS,Rosebury W,Kindt EK,Kowala MC,Panek RL

更新日期：2008-07-01 00:00:00

abstract：:Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are natu...

journal_title：Pharmacological research

authors： Lim DW,Park J,Jung J,Kim SH,Um MY,Yoon M,Kim YT,Han D,Lee C,Lee J

更新日期：2020-11-01 00:00:00

abstract：:Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

journal_title：Pharmacological research

authors： Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

更新日期：2020-11-01 00:00:00

abstract：:Nanotechnology applications in medicine, termed as nanomedicine, have introduced a number of nanoparticles of variable chemistry and architecture for cancer imaging and treatment. Nanotechnology involves engineering multifunctional devices with dimensions at the nanoscale, similar dimensions as those of large biologic...

journal_title：Pharmacological research

authors： Wang M,Thanou M

更新日期：2010-08-01 00:00:00

abstract：:Heart rate recovery at 1min (HRR1) is a strong predictor of all-cause mortality. The effects of statins on the autonomic nervous system may account for their beneficial effects in survival. Our aim was to determine if statin therapy improves heart rate recovery in hypercholesterolemic patients with type 2 diabetes mel...

journal_title：Pharmacological research

authors： Tekin G,Tekin A,Canatar T,Sipahi I,Unsal A,Katircibaşi T,Koçum T,Erol T,Yiğit F,Demircan S,Ermiş N,Sezgin AT,Müderrisoğlu H

更新日期：2006-12-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is an extracellular lipid signaling molecule that acts as a selective, high-affinity ligand for a family of five G protein-coupled receptors. This signaling system was first identified twenty years ago, and has since been shown to regulate a diverse range of physiological processes and di...

journal_title：Pharmacological research

authors： Chew WS,Wang W,Herr DR

更新日期：2016-11-01 00:00:00

abstract：:Advanced glycation end products (AGEs) and their receptor (RAGE) axis contributes to diabetic nephropathy. An oral hypoglycemic agent, metformin may have a potential effect on the inhibition of glycation reactions. Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis ...

journal_title：Pharmacological research

authors： Ishibashi Y,Matsui T,Takeuchi M,Yamagishi S

更新日期：2012-03-01 00:00:00

abstract：:Monoclonal antibodies (mAb) have revolutionised the way in which we treat disease. From cancer to autoimmunity, antibody therapy has been responsible for some of the most impressive clinical responses observed in the last 2 decades. A key component of this success has been their generally low levels of toxicity, and u...

journal_title：Pharmacological research

authors： Vaughan AT,Cragg MS,Beers SA

更新日期：2015-09-01 00:00:00

abstract：:The effect of chloroquine and other antimalarial drugs on glutamate dehydrogenase activity was studied in liver and renal mitochondria as well as in kidney-cortex tubules of rabbit. In permeabilized mitochondria, with free access of substrates and drugs to glutamate dehydrogenase, 100 microns chloroquine decreased bot...

journal_title：Pharmacological research

authors： Jarzyna R,Lenarcik E,Bryła J

更新日期：1997-01-01 00:00:00

abstract：:The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...

journal_title：Pharmacological research

authors： Turan NN,Demiryürek AT,Kanzik I

更新日期：2000-05-01 00:00:00

abstract：:Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...

journal_title：Pharmacological research

authors： Bourre L,Thibaut S,Briffaud A,Lajat Y,Patrice T

更新日期：2002-02-01 00:00:00

abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...

journal_title：Pharmacological research

authors： Faillie JL

更新日期：2017-04-01 00:00:00

abstract：:ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax) are under intensive preclinical and clinical investigation as treatments for hematologic and other malignancies. These small molecules mimic pro-death B-cell lymphoma-2 (Bcl-2) Homology 3 (BH3) domain-only proteins. They also bear a structural resemblance to certa...

journal_title：Pharmacological research

authors： Lever JR,Fergason-Cantrell EA

更新日期：2019-04-01 00:00:00

abstract：:The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus is reviewed. The involvement of these receptors in the hippocampus is suggested by data that ATP is released from hippocampal slices [1] and that it also induces fast synaptic currents in cultured hippocampal neuro...

journal_title：Pharmacological research

authors： Inoue K

更新日期：1998-11-01 00:00:00

abstract：:Psoriasis is a lifelong, chronic and immune-mediated skin disease affecting approximately 1-3% of the Caucasian population. Pathogenesis of psoriasis is associated with an increased expression of tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a pro-inflammatory cytokine and important mediator of cachexia. Anti-...

journal_title：Pharmacological research

authors： Saraceno R,Schipani C,Mazzotta A,Esposito M,Di Renzo L,De Lorenzo A,Chimenti S

更新日期：2008-04-01 00:00:00

abstract：:The concept of compartment evolved in the contexts of radioactivity, physiology, pharmacology and tracer kinetics. Recently compartmental models have been compared with 'physiological models', even though in most cases the same, or stricter hypotheses, are necessary for the validity of these latter models. This paper ...

journal_title：Pharmacological research

authors： Rescigno A

更新日期：2001-10-01 00:00:00

abstract：:We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta...

journal_title：Pharmacological research

authors： Dinca M,Serban MC,Sahebkar A,Mikhailidis DP,Toth PP,Martin SS,Blaha MJ,Blüher M,Gurban C,Penson P,Michos ED,Hernandez AV,Jones SR,Banach M,for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

更新日期：2016-05-01 00:00:00

abstract：:Because many Ca2+ channel blocking agents are known to cause adverse systemic effects, in this study we tested the haemodynamic side effects of nimodipine with and without a mild hypoxic-ischaemic (HI) insult in a newborn piglet model. Fifteen min after completing a brief period of asphyxia we gave i.v. nimodipine as ...

journal_title：Pharmacological research

authors： Raju TN,John E,Shankararao R,Fornell L,Vasa R,Abu-Harb M

更新日期：1996-01-01 00:00:00

abstract：:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a s...

journal_title：Pharmacological research

authors： Brites GS,Ferreira I,Sebastião AI,Silva A,Carrascal M,Neves BM,Cruz MT

更新日期：2020-12-01 00:00:00

abstract：:We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...

journal_title：Pharmacological research

authors： Villa V,Thellung S,Bajetto A,Gatta E,Robello M,Novelli F,Tasso B,Tonelli M,Florio T

更新日期：2016-11-01 00:00:00

abstract：:In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

journal_title：Pharmacological research

authors： Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

更新日期：1992-01-01 00:00:00