Abstract：
:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a significant public health burden. Among skin disorders, allergic contact dermatitis (ACD) is the most prevalent occupational disease and the most common form of immunotoxicity in humans. ACD is a T-cell-mediated skin inflammation resulting from the priming and expansion of allergen-specific CD4+ and CD8+ T cells. The clinical condition is characterized by local skin rash, itchiness, redness, swelling, and lesions, being mainly diagnosed by the patch test. Upon ACD diagnosis, avoiding the exposure to the triggering allergen is the mainstay of treatment to prevent future flares. In cases where avoidance is not possible, the use of a standard of care interim treatments such as steroid creams or ointments, barrier creams, and moisturizers are strongly recommended to alleviate symptoms. In this review, we sought to provide the reader with an overview of the pathophysiology of ACD as well as the currently available pharmacological treatment options. Furthermore, a comprehensive outline of several preventive strategies is also provided.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Brites GS,Ferreira I,Sebastião AI,Silva A,Carrascal M,Neves BM,Cruz MTdoi
10.1016/j.phrs.2020.105282subject
Has Abstractpub_date
2020-12-01 00:00:00pages
105282eissn
1043-6618issn
1096-1186pii
S1043-6618(20)31590-5journal_volume
162pub_type
杂志文章abstract：:Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate pr...
journal_title：Pharmacological research
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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更新日期：2018-11-01 00:00:00
