Abstract:
:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a significant public health burden. Among skin disorders, allergic contact dermatitis (ACD) is the most prevalent occupational disease and the most common form of immunotoxicity in humans. ACD is a T-cell-mediated skin inflammation resulting from the priming and expansion of allergen-specific CD4+ and CD8+ T cells. The clinical condition is characterized by local skin rash, itchiness, redness, swelling, and lesions, being mainly diagnosed by the patch test. Upon ACD diagnosis, avoiding the exposure to the triggering allergen is the mainstay of treatment to prevent future flares. In cases where avoidance is not possible, the use of a standard of care interim treatments such as steroid creams or ointments, barrier creams, and moisturizers are strongly recommended to alleviate symptoms. In this review, we sought to provide the reader with an overview of the pathophysiology of ACD as well as the currently available pharmacological treatment options. Furthermore, a comprehensive outline of several preventive strategies is also provided.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Brites GS,Ferreira I,Sebastião AI,Silva A,Carrascal M,Neves BM,Cruz MTdoi
10.1016/j.phrs.2020.105282subject
Has Abstractpub_date
2020-12-01 00:00:00pages
105282eissn
1043-6618issn
1096-1186pii
S1043-6618(20)31590-5journal_volume
162pub_type
杂志文章abstract::The uridin-diphosphoglucuronyl-transferase (UDP-GT) is a membrane-bound enzyme responsible for glucuronidation of endogenous and exogenous compounds. This work established the UDP-GT activity and its lipid membrane microenvironment in two experimental models: acute paracetamol intoxication, and cholestasis followed by...
journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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doi:10.1016/j.phrs.2009.01.014
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2006.09.007
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/1043-6618(95)80019-0
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2019.104403
更新日期:2019-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2013.07.006
更新日期:2013-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
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更新日期:2019-09-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,meta分析
doi:10.1016/j.phrs.2018.02.005
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1998.0416
更新日期:1999-03-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2020.105045
更新日期:2020-10-01 00:00:00
abstract::The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0398
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1999.0653
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abstract::The molecular complexity of human breast cancer (BC) renders the clinical management of the disease challenging. Long non-coding RNAs (lncRNAs) are promising biomarkers for BC patient stratification, early detection, and disease monitoring. Here, we identified the involvement of the long intergenic non-coding RNA 0108...
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journal_title:Pharmacological research
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pub_type: 杂志文章
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/s1043-6618(02)00321-3
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/1043-6618(95)80086-7
更新日期:1995-06-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2018.02.030
更新日期:2018-04-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1996.0099
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2016.06.021
更新日期:2016-09-01 00:00:00
abstract::Sphingosine 1-phosphate (S1P) is an extracellular lipid signaling molecule that acts as a selective, high-affinity ligand for a family of five G protein-coupled receptors. This signaling system was first identified twenty years ago, and has since been shown to regulate a diverse range of physiological processes and di...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00