Abstract：
:This study investigated the impact of benzodiazepine receptor agonist, midazolam and antagonist, flumazenil, on the rat frontal cortex slices oxygen consumption (QO(2)), in presence and absence of gamma-aminobutyric acid (GABA). QO(2) was polarographically determined, using the biological oxygen monitor. As it was previously shown, GABA on its own decreases QO(2) moderately. Midazolam decreased QO(2) at 1.0mg/kg, whereas flumazenil had no effect. In combination with per se ineffective GABA (10(-6)mol/l), flumazenil showed respiratory depressant action, presumably revealing partial agonistic activity at some of GABA(A) receptor subtypes. However, it completely antagonized effects of midazolam on QO(2), on its own and in presence of GABA. Our results show that in vivo well-established effects of midazolam on cerebral metabolic activity could be reproduced in in vitro settings. Moreover, flumazenil antagonized this action, indicating the role of GABA(A)-benzodiazepine receptor complex activation in QO(2) regulation.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Obradović DI,Savić MM,Andjelković DS,Ugresić ND,Bokonjić DRdoi
10.1016/s1043-6618(02)00289-xkeywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
127-31issue
2eissn
1043-6618issn
1096-1186pii
S104366180200289Xjournal_volume
47pub_type
杂志文章abstract：:The review emphasizes the role of NGF, the most representative member of the neurotrophins family, in cardiac physiopathology with a particular focus on healing and sprouting processes occurring after tissue damage. Cardiac and circulating NGF levels dramatically increase following myocardial injury (MI). A very early...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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abstract：:In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABA(A)receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [(3)H]MK-801 binding, and the GABA(A)receptor bindings we...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.2001.0809
更新日期：2001-05-01 00:00:00
abstract：:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2014.03.003
更新日期：2014-04-01 00:00:00
abstract：:N-acetyl penicillamine (NAP), a derivative of penicillamine and copper chelator has been employed as a potential protector of host stress organ injury during Plasmodium berghei infection in mice. Intramuscular injection of NAP (60 mg kg-1 body wt for 10 days) to P. berghei mice was able to restrict the hepato- and spl...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1997.0233
更新日期：1997-10-01 00:00:00
abstract：:The effect of fluvoxamine (FLV) a selective serotonin reuptake inhibitor agent was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. FLV (8-64 microM) caused a dose-dependent decrease in the rate of contractions (7-52%) and in the contractile force (11-57%). Ouabain alone (2 mic...
journal_title：Pharmacological research
pub_type： 杂志文章
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abstract：:Pre-eclampsia (PE) is a complication of pregnancy that is associated with mortality and morbidity in mothers and fetuses worldwide. Oxygen dysregulation in the placenta, abnormal remodeling of the spiral artery, defective placentation, oxidative stress at the fetal-maternal border, inflammation and angiogenic impairme...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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abstract：:The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...
journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-04-01 00:00:00
abstract：:Metastatic and primary bone cancers are usually accompanied by severe pain that is difficult to manage. In light of the adverse side effects of opioids, manipulation of the endocannabinoid system may provide an effective alternative for the treatment of cancer pain. The present study determined that a local, periphera...
journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2019.04.034
更新日期：2019-07-01 00:00:00
abstract：:In incubated blood mononuclear cells from normal subjects bezafibrate inhibited the incorporation of 14C-acetate into squalene, methylsterols and cholesterol. Similarly, the drug produced a sharp decrease of the incorporation of labelled 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) into non-saponifiable lipids, whi...
journal_title：Pharmacological research
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更新日期：1989-05-01 00:00:00
abstract：:The effect of different L-histidine concentrations on human mammary tumour cell (CG5) proliferation was studied to test the hypothesis of a role of histidine in modulating sex steroid-regulated cell proliferation. Cell growth was only possible in the 10(-5) M and 10(-2) M range, while its inhibition by medroxyprogeste...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0126
更新日期：1997-02-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (...
journal_title：Pharmacological research
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更新日期：2020-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2016.02.025
更新日期：2016-05-01 00:00:00
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更新日期：2016-11-01 00:00:00
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更新日期：2010-02-01 00:00:00
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doi：10.1016/s1043-6618(05)80106-9
更新日期：1991-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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journal_title：Pharmacological research
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更新日期：1997-11-01 00:00:00
abstract：OBJECTIVES:There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS...
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pub_type： 杂志文章,meta分析
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更新日期：2019-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/1043-6618(91)90060-b
更新日期：1991-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2011.04.006
更新日期：2011-09-01 00:00:00
abstract：:Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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abstract：:Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/1043-6618(94)80041-3
更新日期：1994-02-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,meta分析,评审
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abstract：:The potential drug-to-drug interaction between darunavir and raltegravir in the setting of HIV infection is a highly debated issue still unresolved. In the present study we have evaluated the pharmacokinetics of darunavir and ritonavir in 53 HIV-1 infected patients with or without concomitant raltegravir administratio...
journal_title：Pharmacological research
pub_type： 临床试验,杂志文章
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更新日期：2012-02-01 00:00:00
