Vigabatrin does not affect the intestinal absorption of phenytoin in rat duodeno-jejunal loops in situ.

abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

journal_title：Pharmacological research

authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

更新日期：2007-12-01 00:00:00

abstract：:The vascular endothelial growth factor receptor-1 (VEGFR-1) is a membrane receptor for VEGF-A, placenta growth factor (PlGF) and VEGF-B that plays a crucial role in melanoma invasiveness, vasculogenic mimicry and tumor-associated angiogenesis. Furthermore, activation of VEGFR-1 is involved in the mobilization of myelo...

journal_title：Pharmacological research

authors： Lacal PM,Atzori MG,Ruffini F,Scimeca M,Bonanno E,Cicconi R,Mattei M,Bernardini R,D'Atri S,Tentori L,Graziani G

更新日期：2020-09-01 00:00:00

abstract：:In hypothermic rats with acute hypertension induced by intravenous injection of adrenalin, regional changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indication. Evans blue albumin extravasation was determined as a macroscopic finding and a quantitative estimation with...

journal_title：Pharmacological research

authors： Oztaş B,Kaya M,Camurcu S

更新日期：1992-07-01 00:00:00

abstract：:Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the con...

journal_title：Pharmacological research

authors： de Leon J

更新日期：2009-02-01 00:00:00

abstract：:Advanced glycation end products (AGEs) and their receptor (RAGE) axis contributes to diabetic nephropathy. An oral hypoglycemic agent, metformin may have a potential effect on the inhibition of glycation reactions. Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis ...

journal_title：Pharmacological research

authors： Ishibashi Y,Matsui T,Takeuchi M,Yamagishi S

更新日期：2012-03-01 00:00:00

abstract：:CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

journal_title：Pharmacological research

authors： Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

更新日期：2014-03-01 00:00:00

abstract：:In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABA(A)receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [(3)H]MK-801 binding, and the GABA(A)receptor bindings we...

journal_title：Pharmacological research

authors： Kim HS,Hwang SL,Nah SY,Oh S

更新日期：2001-05-01 00:00:00

abstract：:Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and...

journal_title：Pharmacological research

authors： Ávila-Román J,Talero E,de Los Reyes C,García-Mauriño S,Motilva V

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to investigate the effects of manganese chloride on gentamicin-induced nephrotoxicity in rats. Thirty-six adult Wistar Albino rats were divided into six equal groups. They were injected with gentamicin sulfate (100 mg kg(-1) per day i.p.) and manganese chloride (2 or 20 mg kg(-1) per day i.p....

journal_title：Pharmacological research

authors： Ateşşahin A,Karahan I,Yilmaz S,Ceribaşi AO,Princci I

更新日期：2003-12-01 00:00:00

abstract：:The cytokine thymic stromal lymphopoietin (TSLP) is involved in the development and the progression of allergic diseases. It is mainly released by epithelial cells at barriers such as skin and gut in response to danger signals. Overexpression of TSLP in keratinocytes (KC) can provoke the development of a type 2 inflam...

journal_title：Pharmacological research

authors： Schaper K,Rossbach K,Köther B,Stark H,Kietzmann M,Werfel T,Gutzmer R

更新日期：2016-11-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa multiple ascending dose study (0.25, 0.75, 2.0, and 6.0 mg/kg/day) enrolled 48 boys with Duchenne muscular dystrophy (4 to <7 years), with ...

journal_title：Pharmacological research

authors： Conklin LS,Damsker JM,Hoffman EP,Jusko WJ,Mavroudis PD,Schwartz BD,Mengle-Gaw LJ,Smith EC,Mah JK,Guglieri M,Nevo Y,Kuntz N,McDonald CM,Tulinius M,Ryan MM,Webster R,Castro D,Finkel RS,Smith AL,Morgenroth LP,Arrieta

更新日期：2018-10-01 00:00:00

abstract：:Based on the role of ATG7 in the initiation of autophagy, autophagy can be divided into ATG7-dependent selective autophagy and ATG7-independent alternative autophagy. However, the detailed roles of two different types of autophagy in antitumor therapy have not been fully elucidated so far. Here, we for the first time ...

journal_title：Pharmacological research

authors： Zhang P,Ling L,Zheng Z,Zhang Y,Wang R,Wu M,Zhang N,Hu M,Yang X

更新日期：2021-01-01 00:00:00

abstract：:The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseas...

journal_title：Pharmacological research

authors： Hu B,Phan SH

更新日期：2016-06-01 00:00:00

abstract：:Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

journal_title：Pharmacological research

authors： Csaba G,Kovács P,Pállinger E

更新日期：2003-11-01 00:00:00

abstract：:The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied. The results show that EEP and WSD led to decreased levels of blood glucose (FBG), fructosamine (FRU), malonaldehyde (MDA), nitric oxi...

journal_title：Pharmacological research

authors： Fuliang HU,Hepburn HR,Xuan H,Chen M,Daya S,Radloff SE

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:Nuclear factor (NF)-kappaB is a ubiquitous transcription factor that can be activated by multiple signals. To elucidate the role of NF-KB and the effects of NF-kappaB inhibitor on ureteric damages in obstructive uropathy, we conducted this study. METHODS:The expressions of NF-kappaBp50, NF-kappaBp65, interle...

journal_title：Pharmacological research

authors： Chuang YH,Chuang WL,Huang SP,Liu CK,Huang CH

更新日期：2009-10-01 00:00:00

abstract：:The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

journal_title：Pharmacological research

authors： Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

更新日期：1993-02-01 00:00:00

abstract：:Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the loss of barrier function and an elevated sensitivity to environmental insults. An increased release of the endogenous cannabinoid, anandamide in response to inhalation of allergen in asthmatic patients has been reported. ...

journal_title：Pharmacological research

authors： Shang VC,O'Sullivan SE,Kendall DA,Roberts RE

更新日期：2016-03-01 00:00:00

abstract：:Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...

journal_title：Pharmacological research

authors： Cantoni O,Guidarelli A,Sestili P,Giacomoni PU,Cattabeni F

更新日期：1994-02-01 00:00:00

abstract：:The perioperative period is supposed to be a vulnerable period for cancer progression. Results of clinical studies indicate that the use of regional anesthesia can influence and improve oncological outcome of cancer patients. Uncontrolled cell proliferation and resistance to apoptotic cell death are important characte...

journal_title：Pharmacological research

authors： Bundscherer A,Malsy M,Gebhardt K,Metterlein T,Plank C,Wiese CH,Gruber M,Graf BM

更新日期：2015-05-01 00:00:00

abstract：:Memory T cells can be generated and remain long-term in different tissues following infection or immunization. Tissue-resident memory T (TRM) cells are a unique group of memory T cells that form and persist mainly in peripheral non-lymphoid organs. Unlike effector or central memory T (TEM or TCM) cells, TRM cells do n...

journal_title：Pharmacological research

authors： Wang T,Shen Y,Luyten S,Yang Y,Jiang X

更新日期：2020-09-01 00:00:00

abstract：:Electrophysiological effects of bisaramil--a new antiarrhythmic drug under clinical trial--were investigated on isolated heart preparations, at a concentration range of 2.3-23 x 10(-6) M. Bisaramil dose dependently decreased the maximum rate of depolarization (Vmax), action potential amplitude (APA) and overshoot (OS)...

journal_title：Pharmacological research

authors： Paroczai M,Karpati E,Marko R,Kecskemeti V

更新日期：1992-01-01 00:00:00

abstract：:Sesquiterpene lactones (SL) are natural bioactive molecules indicated as potential scaffolds for anti-inflammatory and analgesic drug design. However, their anti-inflammatory applicability remains underestimated since the impact of SL on inflammatory nociception and tissue repair are overlooked. Thus, we used an integ...

journal_title：Pharmacological research

authors： Silva LP,Santos EC,Borges BA,Veloso MP,Chagas-Paula DA,Gonçalves RV,Novaes RD

更新日期：2020-11-16 00:00:00

abstract：:We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

journal_title：Pharmacological research

authors： Campos BG,Ferreira RR,Gomes JC

更新日期：2000-03-01 00:00:00

abstract：:Diarrhea is a common side effect experienced by cancer patients undergoing clinical chemotherapy, such as with 5-fluorouracil (5-FU). However, the precise mechanisms underlying 5-FU-induced diarrhea remain unclear. In the present study, we examined the role of neutrophil in 5-FU-induced diarrhea. Mice were given 5-FU ...

journal_title：Pharmacological research

authors： Sakai H,Sagara A,Matsumoto K,Jo A,Hirosaki A,Takase K,Sugiyama R,Sato K,Ikegami D,Horie S,Matoba M,Narita M

更新日期：2014-09-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

journal_title：Pharmacological research

authors： Shimomura Y,Kitaura Y

更新日期：2018-07-01 00:00:00

abstract：:In incubated blood mononuclear cells from normal subjects bezafibrate inhibited the incorporation of 14C-acetate into squalene, methylsterols and cholesterol. Similarly, the drug produced a sharp decrease of the incorporation of labelled 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) into non-saponifiable lipids, whi...

journal_title：Pharmacological research

authors： Blasi F,Sommariva D,Cosentini R,Cavaiani B,Fasoli A

更新日期：1989-05-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic...

journal_title：Pharmacological research

authors： Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi D

更新日期：2014-04-01 00:00:00

abstract：:Cosmetics are largely diffused substances topically applied to wash, to perfume or to improve the look, nevertheless the number of reported adverse reactions is very low, probably because of underreporting. This could be due to self-diagnosis and self-medication that is common in the presence of not severe reactions. ...

journal_title：Pharmacological research

authors： Di Giovanni C,Arcoraci V,Gambardella L,Sautebin L

更新日期：2006-01-01 00:00:00