Abstract:
:In incubated blood mononuclear cells from normal subjects bezafibrate inhibited the incorporation of 14C-acetate into squalene, methylsterols and cholesterol. Similarly, the drug produced a sharp decrease of the incorporation of labelled 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) into non-saponifiable lipids, while the incorporation of 14C-mevalonate was unaffected by the presence of bezafibrate in the incubation mixture. This strongly suggests that bezafibrate inhibits HMG-CoA reductase activity. In cultured cells from patients with heterozygous familial hypercholesterolaemia the presence of bezafibrate in the incubation medium resulted in an inhibition of the incorporation of labelled acetate into non-saponifiable lipids. Bezafibrate then inhibits cholesterol biosynthesis in cells from normal and hypercholesterolaemic patients and this effect is likely, to contribute to the hypocholesterolaemic activity of the drug.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Blasi F,Sommariva D,Cosentini R,Cavaiani B,Fasoli Adoi
10.1016/s1043-6618(89)80002-7subject
Has Abstractpub_date
1989-05-01 00:00:00pages
247-54issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(89)80002-7journal_volume
21pub_type
杂志文章abstract::The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...
journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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更新日期:1998-04-01 00:00:00
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journal_title:Pharmacological research
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更新日期:2007-06-01 00:00:00
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更新日期:2007-08-01 00:00:00
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更新日期:2017-04-01 00:00:00
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更新日期:2011-08-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/1043-6618(90)90739-z
更新日期:1990-01-01 00:00:00
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journal_title:Pharmacological research
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更新日期:2020-12-19 00:00:00
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journal_title:Pharmacological research
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doi:
更新日期:2003-07-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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更新日期:2012-09-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2004.07.002
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar damage and generally irreversible airflow limitation. Nuclear factor-κB (NF-κB) plays a critical role in COPD pathogenesis. Receptor-interacting protein 2 (Rip2), a 60 kDa adaptor protein, is a positive regulato...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2018.10.016
更新日期:2019-01-01 00:00:00