Abstract：
OBJECTIVES:There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS:This meta-analysis was performed according to the PRISMA statement protocol. A systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran) was performed until June 30, 2018. This review included studies that evaluated the efficacy of etrolizumab or infliximab in ulcerative colitis and were placebo controlled randomized trials. Pooled data from each treatment were indirectly compared using Bucher's method. RESULTS:Seven trials were sufficiently homogeneous to be used for indirect comparison of the induction phase of the treatment. There were no significant differences in clinical remission and serious adverse events between etrolizumab and infliximab. Moreover, adverse events of etrolizumab were significantly less than those of infliximab. However, further trials are required to compare other parameters of efficacy such as the clinical response and mucosal healing of etrolizumab with infliximab in anti-TNF alpha naïve patients.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Motaghi E,Ghasemi-Pirbaluti M,Zabihi Mdoi
10.1016/j.phrs.2018.11.003subject
Has Abstractpub_date
2019-01-01 00:00:00pages
120-125eissn
1043-6618issn
1096-1186pii
S1043-6618(18)31146-0journal_volume
139pub_type
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journal_title：Pharmacological research
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abstract：:The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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abstract：:Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an onco-embryonic antigen presented on chronic lymphocytic leukemia (CLL), but not on normal adult tissues, which promotes CLL-cell survival. Here, ROR1 was identified as a new client of Heat Shock Protein 90 (HSP90) via a mass spectrometry-based screen for ROR...
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journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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abstract：:Echinomycin, in typical DNA minor groove binder, had comparable efficacy compared to 5-FU in the phase II trail of colon cancer treatment. To improve echinomycin's drawback (hydrophobicity, toxicity), we synthesized the YK-2000 series (echinomycin analogues). Among these, YK-2000 had the best in vitro cytotoxicity on ...
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journal_title：Pharmacological research
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doi：10.1016/j.phrs.2006.08.004
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abstract：:Exogenously administered fructose-1,6-diphosphate (FDP) has been studied for its ability to protect tissue during hypoxia or ischemia. Recently, a clear effect of FDP on the central nervous system has raised the question whether FDP can get into the brain. FDP levels were measured in blood, brain, liver, kidney, muscl...
journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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doi：10.1016/j.phrs.2003.10.004
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abstract：:We have shown previously that the antitumor drug, hydroxyurea (HU) is able to induce dose-dependent increases in plasma corticosterone levels in the rat. The drug was administered early in the morning, when the levels of circulating glucocorticoids are low in this species. Normally, in humans under physiological condi...
journal_title：Pharmacological research
pub_type： 临床试验,杂志文章
doi：10.1006/phrs.2000.0709
更新日期：2000-10-01 00:00:00
