:Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patients with 'medium baseline values' did not have any change in lipids, lipoproteins and fibrinolytic parameters while patients with 'high baseline values' had beneficial lipid and lipoprotein changes [decreases in total cholesterol (TC), triglycerides (TG), very low density lipoprotein-cholesterol (VLDLC) and increases in high density lipoprotein-cholesterol (HDLC), and HDLC/TC ratio] after cilnidipine treatment. Changes in lipids were negatively associated with fibrinolysis for the patients with 'medium baseline values' and positively associated in patients with 'high baseline values' after cilnidipine treatment. Reduction in blood pressure was related to fibrinolysis and reduced risk of coronary heart disease in the patients with 'high baseline values' after cilnidipine therapy. These results show that during cilnidipine treatment, the baseline lipid profile levels of the patients may influence the lipid altering actions as well as the interaction between lipids and fibrinolysis. 2000 Academic Press@p$hr Copyright 2000 Academic Press.


Pharmacol Res


Pharmacological research


Ahaneku JE,Sakata K,Urano T,Takada Y,Takada A





Has Abstract


2000-01-01 00:00:00














  • Mechanisms involved in the relaxant action of testosterone in the renal artery from male normoglycemic and diabetic rabbits.

    abstract::Kidney disease is a frequent complication in diabetes, and significant differences have been reported between male and female patients. Our working hypothesis was that diabetes might modify the vascular actions of testosterone in isolated rabbit renal arteries and the mechanisms involved in these actions. Testosterone...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Marrachelli VG,Miranda FJ,Centeno JM,Burguete MC,Castelló-Ruiz M,Jover-Mengual T,Pérez AM,Salom JB,Torregrosa G,Alborch E

    更新日期:2010-02-01 00:00:00

  • The influence of divalent cations on the analgesic effect of opioid and non-opioid drugs.

    abstract::It is generally accepted that divalent cations are involved in the nociceptive pathway. The effect of systemic co-administration of magnesium sulfate and calcium channel blockers (nifedipine, verapamil) on the analgesic effect of opioid (mixed mu/kappa: butorphanol) and non-opioid drugs (paracetamol) was investigated....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Assi AA

    更新日期:2001-06-01 00:00:00

  • Effect of anti-tumor necrosis factor-alpha therapies on body mass index in patients with psoriasis.

    abstract::Psoriasis is a lifelong, chronic and immune-mediated skin disease affecting approximately 1-3% of the Caucasian population. Pathogenesis of psoriasis is associated with an increased expression of tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a pro-inflammatory cytokine and important mediator of cachexia. Anti-...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Saraceno R,Schipani C,Mazzotta A,Esposito M,Di Renzo L,De Lorenzo A,Chimenti S

    更新日期:2008-04-01 00:00:00

  • Poly(ADP-ribosyl)ation and stroke.

    abstract::Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Chiarugi A

    更新日期:2005-07-01 00:00:00

  • Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.

    abstract::Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 recepto...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lethbridge NL,Chazot PL

    更新日期:2016-11-01 00:00:00

  • No-mimetic furoxans: arylsulphonylfuroxans and related compounds.

    abstract::A new class of methylfuroxans and methylfurazans arylthio, arylsulphinyl and arylsulphonyl substituted, characterized by vasodilating and antiaggregatory properties, is described. Vasodilating activity, tested on rabbit aortic rings percontracted with 1 microM noradrenaline, is enhanced by N-oxidation of the furazan r...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ferioli R,Fazzini A,Folco GC,Fruttero R,Calvino R,Gasco A,Bongrani S,Civelli M

    更新日期:1993-10-01 00:00:00

  • Evidence for a role of nitric oxide in the mediation of antiproliferative UVA effects in keratinocytes.

    abstract::Using cultured human keratinocytes, the present study investigates the role of nitric oxide (NO) in the mediation of the antiproliferative effects of ultraviolet light A (UVA). UVA treatment of cells (3-21 J cm (-2)) caused a time- and dose-dependent increase in nitrite formation in a micromolar range. This effect was...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Podhaisky HP,Klapperstück T,Riemschneider S,Wohlrab W

    更新日期:2002-03-01 00:00:00

  • Exogenous glutathione increases endurance to muscle effort in mice.

    abstract::Many data suggest an involvement of toxic oxygen radicals in the termination of endurance to muscle fatigue. Being reduced glutathione (GSH), an efficient intracellular physiological antioxidant, experiments have been performed to discover whether exogenous GSH modifies endurance to exhaustive swimming in mice. GSH wa...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Novelli GP,Falsini S,Bracciotti G

    更新日期:1991-02-01 00:00:00

  • Pharmacokinetics of fructose-1,6-diphosphate after intraperitoneal and oral administration to adult rats.

    abstract::Exogenously administered fructose-1,6-diphosphate (FDP) has been studied for its ability to protect tissue during hypoxia or ischemia. Recently, a clear effect of FDP on the central nervous system has raised the question whether FDP can get into the brain. FDP levels were measured in blood, brain, liver, kidney, muscl...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xu K,Stringer JL

    更新日期:2008-03-01 00:00:00

  • Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice.

    abstract::Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are natu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lim DW,Park J,Jung J,Kim SH,Um MY,Yoon M,Kim YT,Han D,Lee C,Lee J

    更新日期:2020-11-01 00:00:00

  • Levosulpiride: a review of its clinical use in psychiatry.

    abstract::Levosulpiride is the (-)-enantiomer of sulpiride. It has shown greater central antidopaminergic activity, antiemetic and antidyspeptic effects and lower acute toxicity than both the racemic and dextro forms. Several clinical studies indicate that levosulpiride has therapeutic efficacy in depressive and somatoform diso...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mucci A,Nolfe G,Maj M

    更新日期:1995-02-01 00:00:00

  • A review of gene- and cell-based therapies for familial hypercholesterolemia.

    abstract::Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Hajighasemi S,Mahdavi Gorabi A,Bianconi V,Pirro M,Banach M,Ahmadi Tafti H,Reiner Ž,Sahebkar A

    更新日期:2019-05-01 00:00:00

  • Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries.

    abstract:OBJECTIVE:The vasorelaxant effect of 2-arachidonoylglycerol (2-AG) has been well characterised in animals. 2-AG is present in human vascular cells and is up-regulated in cardiovascular pathophysiology. However, the acute vascular actions of 2-AG have not been explored in humans. APPROACH:Mesenteric arteries were obtai...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Stanley CP,O'Sullivan SE

    更新日期:2014-03-01 00:00:00

  • Pharmacogenomic analyzis of the responsiveness of gastrointestinal tumor cell lines to drug therapy: A transportome approach.

    abstract::In this study, we have addressed the pharmacogenomic basis of the response of gastrointestinal tumors to six anticancer drugs using a panel of fifteen cell lines derived from pancreatic, stomach and biliary tract cancers. We determined the constitutive expression levels of 96 genes, whose encoded proteins contribute t...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Grañé-Boladeras N,Pérez-Torras S,Lozano JJ,Romero MR,Mazo A,Marín JJG,Pastor-Anglada M

    更新日期:2016-11-01 00:00:00

  • A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment.

    abstract::A traditional Chinese medicine (TCM) formula (SL) comprising Sophorae Flos and Lonicerae Japonicae Flos was used for treating melanoma in ancient China. We have previously shown that an ethanolic extract of SL (SLE) possesses anti-melanoma effects and suppresses STAT3 signaling in vitro and in vivo. STAT3 has been lin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Liu YX,Bai JX,Li T,Fu XQ,Guo H,Zhu PL,Chan YC,Chou JY,Yin CL,Li JK,Wang YP,Chen YJ,Yu ZL

    更新日期:2019-04-01 00:00:00

  • Novel arachidonate metabolites generated by cytochrome P450-dependent mono-oxygenases.

    abstract::Cytochrome P450-dependent arachidonic acid (AA) metabolism by medullary thick ascending limb of the loop of Henle (mTALH) cells, corneal epithelium and other transporting epithelia, such as those of the intestines, generate metabolites which affect Na(+)-K(+)-ATPase activity, vasomotion and, thereby, organ function. F...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Carroll MA,Quilley CP,McGiff JC

    更新日期:1991-05-01 00:00:00

  • L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing.

    abstract::Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cantoni O,Guidarelli A,Sestili P,Giacomoni PU,Cattabeni F

    更新日期:1994-02-01 00:00:00

  • Novel indole-based compounds that differentiate alkylindole-sensitive receptors from cannabinoid receptors and microtubules: Characterization of their activity on glioma cell migration.

    abstract::Indole-based compounds, such as the alkyl-indole (AI) compound WIN55212-2, activate the cannabinoid receptors, CB1 and CB2, two well-characterized G protein-coupled receptors (GPCR). Reports indicate that several indole-based cannabinoid agonists, including WIN55212-2, lack selectivity and interact with at least two a...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Fung S,Xu C,Hamel E,Wager-Miller JB,Woodruff G,Miller A,Sanford C,Mackie K,Stella N

    更新日期:2017-01-01 00:00:00

  • Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes.

    abstract::The aim of this study was to investigate effect of antiemetics on G6PD and antioxidant enzymes. Antiemetics are currently being used to reduce or prevent nausea and vomiting in patients. This is the first study to show effect of antiemetics on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ozmen I,Küfrevioglu OI

    更新日期:2004-11-01 00:00:00

  • Neurochemical studies with the anticonvulsant felbamate in mouse brain.

    abstract::Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Fraser CM,Sills GJ,Forrest G,Thompson GG,Brodie MJ

    更新日期:1999-09-01 00:00:00

  • Evidence against the existence of GABA-B receptor sites in rat cerebrovascular tree.

    abstract::By the use of combined radioreceptor binding and autoradiographic techniques we attempted to analyse the biochemical characteristics and the anatomical localization of GABA-B receptors in sections of rat circle of Willis and pialarachnoid arteries. 3H-GABA in the presence of 40 microM isoguvacine and 2.5 mM CaCl2 was ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Napoleone P,Ferrante F,Amenta F

    更新日期:1990-05-01 00:00:00

  • Anti-diabetic effects of Gymnema yunnanense extract.

    abstract::In this study, we evaluated anti-hyperglycemic effect and body weight reduction activity of Gymnema yunnanense extract in obese ob/ob and diabetic db/db mice. Animals received daily intraperitoneal injections of the extract 100 mg/kg for 12 days. On Day 5, the extract-treated ob/ob mice had significantly lower fasting...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xie JT,Wang A,Mehendale S,Wu J,Aung HH,Dey L,Qiu S,Yuan CS

    更新日期:2003-04-01 00:00:00

  • Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs.

    abstract::The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clon...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Miranda HF,Pinardi G

    更新日期:2004-09-01 00:00:00

  • A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients.

    abstract:BACKGROUND:Overexpression of heat shock proteins (Hsps) is associated to myocardial protection and it has been suggested that they could be a marker of cardiac preservation in conditions such as extracorporeal circulation. Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Giannessi D,Caselli C,Vitale RL,Crucean A,Murzi B,Del Ry S,Vanini V,Biagini A

    更新日期:2003-11-01 00:00:00

  • Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis.

    abstract::Pulsatilla Decoction (Bai-Tou-Weng-Tang) has been used medically in China for thousands of years for the treatment of diseases caused by bacteria. In recent decades, Pulsatilla Decoction is becoming a well-known formula prescription used for the treatment of ulcerative colitis in traditional Chinese medicine. Pulsatil...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Li YH,Zou M,Han Q,Deng LR,Weinshilboum RM

    更新日期:2020-10-01 00:00:00

  • Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases.

    abstract::Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Huber G,Schuster F,Raasch W

    更新日期:2017-11-01 00:00:00

  • Testicular toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q10 and L-carnitine in mice.

    abstract::The protective effect of L-carnitine or coenzyme Q10 (CoQ10) against high magnetic field (20 mT) induced testicular toxicity in mice were evaluated. Animals were injected with L-carnitine (200 mg kg(-1), i.p.) or CoQ10 (200 mg kg(-1), p.o.) 1h before exposure to fractionated doses (30 min per day, three times per week...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ramadan LA,Abd-Allah AR,Aly HA,Saad-el-Din AA

    更新日期:2002-10-01 00:00:00

  • The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone.

    abstract::The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

    更新日期:1993-02-01 00:00:00

  • Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus.

    abstract::Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

    更新日期:2017-03-01 00:00:00

  • Conjugated linoleic acid: implications for human health.

    abstract::Conjugated linoleic acid (CLA) is being sold as a panacea that has the capability of reducing or eliminating cancer, preventing heart disease, improving immune function, and altering body composition to treat obesity or build lean body mass. Unfortunately, there has been very little published human research on CLA. Th...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Whigham LD,Cook ME,Atkinson RL

    更新日期:2000-12-01 00:00:00