Abstract：
:Long non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular homeostasis through the decay of damaged or unwanted proteins and dysfunctional cytoplasmic organelles. The impairment of the autophagy process has been described in numerous diseases. The autophagy possess can have either a protective or a detrimental role in cells depending on its activation status and other cellular conditions. LncRNAs have been shown to have an important function in the regulation of important biological processes such as autophagy. The relationship between lncRNAs and autophagy has been shown to be involved in the progression and possibly in the prevention of many diseases. In this review, recent findings on the regulatory roles of lncRNAs in the cell autophagy pathway, as well as their relevance to different diseases such as cardiovascular disease, cerebral ischemic stroke and cancer are highlighted.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Barangi S,Hayes AW,Reiter R,Karimi Gdoi
10.1016/j.phrs.2019.02.010subject
Has Abstractpub_date
2019-04-01 00:00:00pages
22-29eissn
1043-6618issn
1096-1186pii
S1043-6618(19)30177-Xjournal_volume
142pub_type
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pub_type： 杂志文章,评审
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更新日期：1997-09-01 00:00:00
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更新日期：2020-08-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2016-09-01 00:00:00
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更新日期：2011-07-01 00:00:00
abstract：:It has been reported that patients with Hodgkin's disease (HD) show altered porphyrin metabolism, and suggested that the cause is the neoplastic process itself. If this is true, disease progression should be associated with higher levels of porphyrin excretion. The aim of this study was to evaluate urinary coproporphy...
journal_title：Pharmacological research
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doi：10.1016/j.phrs.2004.09.005
更新日期：2005-03-01 00:00:00
