Abstract:
:This article summarizes the discovery and the development of endothelial biology with a special focus on the role of endothelium-dependent vasoconstriction. The physician-scientist Paul Michel Vanhoutte contributed many of the initial observations that helped to understand and form the main concepts of modern vascular biology involving endothelial regulation. His laboratory was the first to report endothelial cell-derived vasoconstriction in 1981, followed by the characterization of an endothelium-derived constricting factor published by Hickey et al. in 1985, which was later identified as the endothelin peptide by Yanagisawa et al. in 1988. The identification of the receptor subtypes of this endothelial vasocontrictor two years later, which were named ET(A) and ET(B) receptors according to suggestions put forward by Vanhoutte, ultimately resulted in the development of the only new class of drugs that is entirely based on endothelial cell research. More than a quarter century after Vanhoutte's initial description of endothelial vasoconstriction, this first drug class specifically targeting an endothelial vasoconstrictor, the endothelin receptor antagonists, has been firmly established in cardiovascular medicine for the treatment of pulmonary hypertension. This novel therapeutic principle had its beginnings in Vanhoutte's discovery made 30 years ago.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Barton Mdoi
10.1016/j.phrs.2011.02.013subject
Has Abstractpub_date
2011-06-01 00:00:00pages
455-62issue
6eissn
1043-6618issn
1096-1186pii
S1043-6618(11)00064-8journal_volume
63pub_type
杂志文章,评审abstract::Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1996.0067
更新日期:1996-07-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Pharmacological research
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2012.01.003
更新日期:2012-04-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2009.04.006
更新日期:2009-09-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2017.07.025
更新日期:2017-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2016.07.001
更新日期:2017-04-01 00:00:00
abstract::The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/s1043-6618(03)00179-8
更新日期:2003-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2019.104579
更新日期:2020-02-01 00:00:00
abstract::Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1996.0021
更新日期:1996-02-01 00:00:00
abstract::6-Mercaptopurine is a cytotoxic and immunosuppressant drug. The use of this drug is limited due to its poor bioavailability and short plasma half-life. In order to nullify these drawbacks, 6-mercaptopurine-chitosan nanoparticles (6-MP-CNPs) were prepared and evaluated to study the influence of preparation conditions o...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2015.07.025
更新日期:2015-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1999.0653
更新日期:2000-06-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2004.05.007
更新日期:2004-11-01 00:00:00
abstract::Male weanling Wistar rats were fed a 4% cholestyramine diet and used as a model to demonstrate that a reduction in serum low density lipoproteins stimulates de novo cholesterogenesis leading to DNA synthesis and cell proliferation. Feeding this diet resulted in a decrease in serum very low density lipoproteins and low...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/1043-6618(89)90195-3
更新日期:1989-09-01 00:00:00
abstract::The EEG and behavioural changes induced by the administration of polyamines (spermine and spermidine) were studied in rabbit. Spermine and spermidine were administered at different doses (200 and 400 micrograms) into the mesencephalic ventricle (i.c.v.) both as a bolus and in constant perfusion (60 min duration). We a...
journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2020.104729
更新日期:2020-05-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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abstract::Pulsatilla Decoction (Bai-Tou-Weng-Tang) has been used medically in China for thousands of years for the treatment of diseases caused by bacteria. In recent decades, Pulsatilla Decoction is becoming a well-known formula prescription used for the treatment of ulcerative colitis in traditional Chinese medicine. Pulsatil...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
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abstract::Based on the role of ATG7 in the initiation of autophagy, autophagy can be divided into ATG7-dependent selective autophagy and ATG7-independent alternative autophagy. However, the detailed roles of two different types of autophagy in antitumor therapy have not been fully elucidated so far. Here, we for the first time ...
journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
abstract::Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics. Therefore, serum osteocalcin (BGP) and total alkalin...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0486
更新日期:1999-08-01 00:00:00
abstract::Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulati...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00