Pharmacological studies of cardamom oil in animals.

abstract：:Cysteamine, a potent somatostatin depletor, was used in the present study to investigate the role of endogenous somatostatin in acute peripheral inflammation. The acute inflammation was induced by intraplantar injection of carrageenan (1%), histamine (5 micromol), or formalin (2.5%) in the rat hind paw. The induced in...

journal_title：Pharmacological research

authors： Salam OM

更新日期：2002-04-01 00:00:00

abstract：:Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

journal_title：Pharmacological research

authors： Mougenot N,Médiani O,Lechat P

更新日期：2005-04-01 00:00:00

abstract：:This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potent...

journal_title：Pharmacological research

authors： Carpentieri A,Díaz de Barboza G,Areco V,Peralta López M,Tolosa de Talamoni N

更新日期：2012-04-01 00:00:00

abstract：:The endocannabinoid signalling system includes: (1) at least two G-protein-coupled receptors, known as the cannabinoid CB(1) and CB(2) receptors and discovered following studies on the mechanism of action of Delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant Cannabis sativa; (2) the endo...

journal_title：Pharmacological research

authors： Di Marzo V

更新日期：2009-08-01 00:00:00

abstract：:The isolated heart is deservedly one of the most popular experimental models in cardiovascular research, both in terms of cost and the quality and quantity of data it provides. However, it is a deceptively simple model, capable of throwing many problems in the path of the inexperienced or unwary perfuser. The followin...

journal_title：Pharmacological research

authors： Sutherland FJ,Hearse DJ

更新日期：2000-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression by targeting specific mRNAs for degradation or translation repression. Changes in miRNAs expression profiles have been reported in several neurodegenerative disorders such as Alzheimer's disease (AD) and related tauopathies...

journal_title：Pharmacological research

authors： Bazrgar M,Khodabakhsh P,Mohagheghi F,Prudencio M,Ahmadiani A

更新日期：2020-05-01 00:00:00

abstract：:Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

journal_title：Pharmacological research

authors： Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

更新日期：1999-08-01 00:00:00

abstract：:Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK3-receptors on allergen-induced pulmonary inflammation, studies were performed on ovalbumin (OVA) sensitized and challen...

journal_title：Pharmacological research

authors： Kung TT,Crawley Y,Jones H,Luo B,Gilchrest H,Greenfeder S,Anthes JC,Lira S,Wiekowski M,Cook DN,Hey JA,Egan RW,Chapman RW

更新日期：2004-12-01 00:00:00

abstract：:A novel alkynylthiophene series of cannabinoid CB1 receptor antagonists has been described to exhibit distinct intrinsic activities with minimal substructure modifications. The three representatives, BPR0432, BPR0568 and BPR0569, functioning as a neutral antagonist, an inverse agonist and a partial agonist, respective...

journal_title：Pharmacological research

authors： Lin Y,Shia KS,Hsiao WC,Hsieh WP,Yeh TK,Tseng SL,Hsu CY,Chao YS,Hung MS

更新日期：2010-10-01 00:00:00

abstract：:Skeletal muscle fitness is vital for human health and disease and is determined by the capacity for burning fuel, mitochondrial ATP production, and contraction. High quality mitochondria in skeletal muscle are essential for maintaining energy homeostasis in response to a myriad of physiologic or pathophysiological str...

journal_title：Pharmacological research

authors： Xu Z,Fu T,Guo Q,Sun W,Gan Z

更新日期：2019-03-01 00:00:00

abstract：:There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

journal_title：Pharmacological research

authors： Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

更新日期：2016-09-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

journal_title：Pharmacological research

authors： Shimomura Y,Kitaura Y

更新日期：2018-07-01 00:00:00

abstract：:The study was undertaken using selected pharmacodynamic parameters to describe the effects of porcine galanin(1-29)-NH2; porcine galanin fragments; galantide; porcine galanin(1-14)-[alpha-aminobutyric acid8]scyliorhinin-I and the analogues of the latter peptides on rat isolated gastric fundus muscle. All tested peptid...

journal_title：Pharmacological research

authors： Korolkiewicz R,Sliwiński W,Rekowski P,Halama-Borowiec A,Mucha P,Szczurowicz A,Korolkiewicz KZ

更新日期：1997-01-01 00:00:00

abstract：:Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspen...

journal_title：Pharmacological research

authors： Ramos-Romero S,Pérez-Cano FJ,Ramiro-Puig E,Franch A,Castell M

更新日期：2012-09-01 00:00:00

abstract：:Many data suggest an involvement of toxic oxygen radicals in the termination of endurance to muscle fatigue. Being reduced glutathione (GSH), an efficient intracellular physiological antioxidant, experiments have been performed to discover whether exogenous GSH modifies endurance to exhaustive swimming in mice. GSH wa...

journal_title：Pharmacological research

authors： Novelli GP,Falsini S,Bracciotti G

更新日期：1991-02-01 00:00:00

abstract：:Our preliminary data suggested that 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene [Viale M, Ottone M, Chiavarina B, Mariggiò MA, Prevosto C, Dell'Erba C, et al. Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadi...

journal_title：Pharmacological research

authors： Dell'Erba C,Chiavarina B,Fenoglio C,Petrillo G,Cordazzo C,Boncompagni E,Spinelli D,Ognio E,Aiello C,Mariggiò MA,Viale M

更新日期：2005-09-01 00:00:00

abstract：:Targeting on the IKKβ to discover anti-inflammatory drugs has been launched for ten years, due to its predominant role in canonical NF-κB signaling. In the current study, we identified a novel IKKβ inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis. We found that ELL ...

journal_title：Pharmacological research

authors： Chen Q,Liu J,Zhuang Y,Bai LP,Yuan Q,Zheng S,Liao K,Khan MA,Wu Q,Luo C,Liu L,Wang H,Li T

更新日期：2019-11-01 00:00:00

abstract：:In the isolated myometrium obtained from pregnant women, diphenylhydantoin inhibited both spontaneous and K(+)-evoked contractions within the same range of potency. Nicardipine was less effective in inhibiting spontaneous than K(+)-induced contractions, whereas trifluoperazine was only effective against spontaneous co...

journal_title：Pharmacological research

authors： Medeiros YS,Calixto JB

更新日期：1990-09-01 00:00:00

abstract：:TMEM16A plays critical roles in physiological process and may serve as drug targets for diverse diseases. Recently, TMEM16A has started to be regarded as potential primary lung adenocarcinoma targets. Here, we identified that arctigenin, a natural compound, is a novel TMEM16A inhibitor, and it can suppress lung adenoc...

journal_title：Pharmacological research

authors： Guo S,Chen Y,Shi S,Wang X,Zhang H,Zhan Y,An H

更新日期：2020-05-01 00:00:00

abstract：:Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present study investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial infarction given specifically at reperfusion and the signalling pathway involved. Thiobutabarb...

journal_title：Pharmacological research

authors： Karwi QG,Whiteman M,Wood ME,Torregrossa R,Baxter GF

更新日期：2016-09-01 00:00:00

abstract：:Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptome analysis, we comp...

journal_title：Pharmacological research

authors： Chen Y,Brooks MJ,Gieser L,Swaroop A,Palczewski K

更新日期：2017-01-01 00:00:00

abstract：:In the present study, hyperglycaemia was induced by intraperitoneal injection of streptozotocin (65 mg/kg). Treatment with glibenclamide (GB) in a dose of 0.45 or 0.9 mg/kg significantly decreased plasma glucose level in a dose-related manner. Administration of nadolol (ND) in a dose of 5 or 10 mg/kg did not affect pl...

journal_title：Pharmacological research

authors： Abdel Aziz AH,Moustafa AM,Abd Ellah MF,el-Mazar MA

更新日期：1996-07-01 00:00:00

abstract：:In the present study the effect of ketamine on the contractions caused by propoxur and phoxim on the isolated guinea pig ileum was investigated. Ketamine was found able to inhibit in a concentration-dependent manner the contractile responses of the ileum to propoxur and phoxim, while it did not significantly modify th...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Kounenis G,Elezoglou V

更新日期：1994-08-01 00:00:00

abstract：:The survey was carried out, between September 1995 and May 1996, in order to describe the prescriptive behaviour among Sicilian general practitioners (GPs) in choosing an empirical antibiotic regimen for LRTIs in adult patients and begin an educational process which involves the same GPs in decisions regarding their p...

journal_title：Pharmacological research

authors： Mazzaglia G,Arcoraci V,Greco S,Cucinotta G,Cazzola M,Caputi AP

更新日期：1999-07-01 00:00:00

abstract：:Excess fructose consumption causes high prevalence of metabolic syndrome and inflammatory liver diseases. The aim of the current study was to investigate the therapeutic effects and underlying molecular mechanisms of curcumin and allopurinol in high fructose-induced hepatic inflammation. Male Sprague-Dawley rats were ...

journal_title：Pharmacological research

authors： Ding XQ,Wu WY,Jiao RQ,Gu TT,Xu Q,Pan Y,Kong LD

更新日期：2018-11-01 00:00:00

abstract：:Plasma lipid and lipoprotein levels were evaluated in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin. Mean plasma total cholesterol (TC), low-density lipoprotein-cholesterol (LDLC), triglyceride (TG), very low density lipoprotein-cholesterol (VLDLC) and the L...

journal_title：Pharmacological research

authors： Ahaneku JE,Taylor GO,Agbedana EO,Walker O,Salako LA

更新日期：1994-10-01 00:00:00

abstract：:Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

journal_title：Pharmacological research

authors： Ginawi OT

更新日期：2003-09-01 00:00:00

abstract：:The altered vascular responses to various vasopressors and relaxants have been well reported in various animal models of hypertension, insulin resistance and diabetes. Though the role of oxidative stress (increased superoxide levels) associated with these altered vascular responses in hyperglycemic/diabetic state is w...

journal_title：Pharmacological research

authors： Viswanad B,Srinivasan K,Kaul CL,Ramarao P

更新日期：2006-03-01 00:00:00

abstract：:The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...

journal_title：Pharmacological research

authors： Abo El Sooud K

更新日期：2003-10-01 00:00:00

abstract：:Moderate wine consumption has been shown to reduce cardiovascular (CV) risk, due to alcohol and polyphenolic compounds, such as resveratrol. We investigated the associations between total urinary resveratrol metabolites (TRMs) as biomarkers of wine and resveratrol consumption and CV risk factors in a large cross-secti...

journal_title：Pharmacological research

authors： Zamora-Ros R,Urpi-Sarda M,Lamuela-Raventós RM,Martínez-González MÁ,Salas-Salvadó J,Arós F,Fitó M,Lapetra J,Estruch R,Andres-Lacueva C,PREDIMED Study Investigators.

更新日期：2012-06-01 00:00:00