Pharmacological studies of cardamom oil in animals.

abstract：:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic...

journal_title：Pharmacological research

authors： Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi D

更新日期：2014-04-01 00:00:00

abstract：:Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the con...

journal_title：Pharmacological research

authors： de Leon J

更新日期：2009-02-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:This study investigated the impact of benzodiazepine receptor agonist, midazolam and antagonist, flumazenil, on the rat frontal cortex slices oxygen consumption (QO(2)), in presence and absence of gamma-aminobutyric acid (GABA). QO(2) was polarographically determined, using the biological oxygen monitor. As it was pre...

journal_title：Pharmacological research

authors： Obradović DI,Savić MM,Andjelković DS,Ugresić ND,Bokonjić DR

更新日期：2003-02-01 00:00:00

abstract：AIM:To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation. METHODS:We enrolled 532 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of...

journal_title：Pharmacological research

authors： Derosa G,Maffioli P,Scelsi L,Bestetti A,Vanasia M,Cicero AFG,Spinardi L,Bentivenga C,Esposti DD,Caprio M,Borghi C,Pitt B,Cosentino E

更新日期：2019-03-01 00:00:00

abstract：:Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg(-1)day(-1)for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a ...

journal_title：Pharmacological research

authors： Ali BH,Al-Qarawi AA

更新日期：2000-07-01 00:00:00

abstract：:Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is evaluated on two melanoma cell lines with dissimilar molecular background, B16 and A375. The treatment of both cell lines...

journal_title：Pharmacological research

authors： Krajnović T,Kaluđerović GN,Wessjohann LA,Mijatović S,Maksimović-Ivanić D

更新日期：2016-03-01 00:00:00

abstract：:Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...

journal_title：Pharmacological research

authors： Fraser CM,Sills GJ,Forrest G,Thompson GG,Brodie MJ

更新日期：1999-09-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide that afflicts human health. With the in-depth study of the disease, its pathogenesis has gradually become clear. Although great breakthroughs have been made in the research of ALD, the research and development of drugs related to ALD has...

journal_title：Pharmacological research

authors： Hu S,Li SW,Yan Q,Hu XP,Li LY,Zhou H,Pan LX,Li J,Shen CP,Xu T

更新日期：2019-12-01 00:00:00

abstract：:Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

journal_title：Pharmacological research

authors： Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

更新日期：2000-07-01 00:00:00

abstract：:Boron analogues of phosphonoacetates proved to be potent hypolipidaemic agents in rodents, lowering both serum cholesterol and triglyceride levels. (C2H5O)3PBH2COOCH3 proved to be the most effective agent in mice, lowering serum cholesterol 46% and serum triglycerides 54% after 16 days. (C2H5O)3PBH2COOH and Na+H+(C2H5...

journal_title：Pharmacological research

authors： Hall IH,Wong OT,Sood A,Sood CK,Spielvogel BF,Shrewsbury RP,Morse KW

更新日期：1992-04-01 00:00:00

abstract：:Pulmonary fibrosis is a chronic condition characterized by progressive scarring of lung parenchyma. The aim of this study was to examine the effects of an ultramicronized preparation of palmitoylethanolamide (PEA-um(®)), an endogenous fatty acid amide, in mice subjected to idiopathic pulmonary fibrosis. Idiopathic pul...

journal_title：Pharmacological research

authors： Di Paola R,Impellizzeri D,Fusco R,Cordaro M,Siracusa R,Crupi R,Esposito E,Cuzzocrea S

更新日期：2016-09-01 00:00:00

abstract：:The suppression of the abnormal systemic immune response constitutes a primary strategy for treatment of rheumatoid arthritis (RA); toward this end, the identification of natural compounds with immunosuppressive activity represents a promising strategy for RA drug discovery. Cinnamtannin D1 (CTD-1), a polyphenolic com...

journal_title：Pharmacological research

authors： Shi C,Zhang H,Wang X,Jin B,Jia Q,Li Y,Yang Y

更新日期：2020-01-01 00:00:00

abstract：:Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects...

journal_title：Pharmacological research

authors： Garbarino VR,Santos TA,Nelson AR,Zhang WQ,Smolik CM,Javors MA,Daws LC,Gould GG

更新日期：2019-02-01 00:00:00

abstract：:We compared the protective abilities of Mangifera indica L. stem bark extract (Vimang) 50-250 mgkg(-1), mangiferin 50 mgkg(-1), vitamin C 100 mgkg(-1), vitamin E 100 mgkg(-1)and beta -carotene 50 mgkg(-1)against the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage in serum, liver, brain as well as i...

journal_title：Pharmacological research

authors： Sánchez GM,Re L,Giuliani A,Núñez-Sellés AJ,Davison GP,León-Fernández OS

更新日期：2000-12-01 00:00:00

abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...

journal_title：Pharmacological research

authors： Misirkic M,Janjetovic K,Vucicevic L,Tovilovic G,Ristic B,Vilimanovich U,Harhaji-Trajkovic L,Sumarac-Dumanovic M,Micic D,Bumbasirevic V,Trajkovic V

更新日期：2012-01-01 00:00:00

abstract：:Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase involved in several cellular processes. In recent years, SHP2 has been the focus of significant attention in human diseases, particular in cancer. Several studies have shown that SHP2 plays an important role in regulating immune cel...

journal_title：Pharmacological research

authors： Liu Q,Qu J,Zhao M,Xu Q,Sun Y

更新日期：2020-02-01 00:00:00

abstract：:The effects of the P(2)-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl- 2('),4(')- disulphonic acid (PPADS), the nitric oxide (NO) synthase inhibitor N(G)-nitro- l -arginine (l -NOARG), the K(+)-channel blocker apamin, the pituitary adenylate cyclase activating peptide (PACAP) antagonist PACAP(6-38) and the s...

journal_title：Pharmacological research

authors： Rózsai B,Lázár Z,Benkó R,Barthó L

更新日期：2001-01-01 00:00:00

abstract：:Availability of highly active antiretroviral therapy has dramatically increased survival rates and substantially modified the course of HIV infection, which has now become a chronic disease both in adults and in children. Treatment strategies in paediatric patients have to face with specific challenges associated with...

journal_title：Pharmacological research

authors： Viganò A,Manfredini V,Penagini F,Giacomet V,Zuccotti GV

更新日期：2011-07-01 00:00:00

abstract：:The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

journal_title：Pharmacological research

authors： Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

更新日期：1993-02-01 00:00:00

abstract：:There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

journal_title：Pharmacological research

authors： Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

更新日期：2016-09-01 00:00:00

abstract：:This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent wi...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Nikolaidis E,Kounenis G

更新日期：2001-09-01 00:00:00

abstract：:Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptome analysis, we comp...

journal_title：Pharmacological research

authors： Chen Y,Brooks MJ,Gieser L,Swaroop A,Palczewski K

更新日期：2017-01-01 00:00:00

abstract：:The hepatoprotective effects of acetylbergenin were examined against D -galactosamine (GalN)-induced liver damage in rats, compared with that of bergenin reported previously. Acetylbergenin was synthesized from acetylation of bergenin, isolated from Mallotus japonicus, to increase lipophilic and physiological activiti...

journal_title：Pharmacological research

authors： Lim HK,Kim HS,Choi HS,Oh S,Jang CG,Choi J,Kim SH,Chang MJ

更新日期：2000-11-01 00:00:00

abstract：:Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like...

journal_title：Pharmacological research

authors： Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L

更新日期：2012-01-01 00:00:00

abstract：:The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an inc...

journal_title：Pharmacological research

authors： Pini A,Obara I,Battell E,Chazot PL,Rosa AC

更新日期：2016-09-01 00:00:00

abstract：:Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of p...

journal_title：Pharmacological research

authors： Nadeem A,Al-Harbi NO,Al-Harbi MM,El-Sherbeeny AM,Ahmad SF,Siddiqui N,Ansari MA,Zoheir KM,Attia SM,Al-Hosaini KA,Al-Sharary SD

更新日期：2015-09-01 00:00:00

abstract：:Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulati...

journal_title：Pharmacological research

authors： Cho E,Park M

更新日期：2016-09-01 00:00:00

abstract：:Vascular responses to hypoxia are heterogeneous and involve the release of vasodilators substances such as nitric oxide (NO) and prostacyclin (PGI(2)). In vitro studies have shown that Vitamin K(1) modulates the release of arachidonic acid (AA) in vascular cells, and thus inhibits the capacity of blood vessels to synt...

journal_title：Pharmacological research

authors： Tirapelli CR,Mingatto FE,De Godoy MA,Ferreira R,De Oliviera AM

更新日期：2002-12-01 00:00:00

abstract：:Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate pr...

journal_title：Pharmacological research

authors： Oner-Iyidoğan Y,Oner P,Koçak H,Lama A,Gürdöl F,Bekpinar S,Unur N,Ozbek-Kir Z

更新日期：2005-10-01 00:00:00