Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics.

abstract：:The vascular endothelial growth factor receptor-1 (VEGFR-1) is a membrane receptor for VEGF-A, placenta growth factor (PlGF) and VEGF-B that plays a crucial role in melanoma invasiveness, vasculogenic mimicry and tumor-associated angiogenesis. Furthermore, activation of VEGFR-1 is involved in the mobilization of myelo...

journal_title：Pharmacological research

authors： Lacal PM,Atzori MG,Ruffini F,Scimeca M,Bonanno E,Cicconi R,Mattei M,Bernardini R,D'Atri S,Tentori L,Graziani G

更新日期：2020-09-01 00:00:00

abstract：:The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found i...

journal_title：Pharmacological research

authors： Peng R,Zhang M,Wang H,Lin J,Wang H,Wang F,Liu L,Zhao Q,Liu J

更新日期：2020-11-01 00:00:00

abstract：:Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increas...

journal_title：Pharmacological research

authors： Zheng L,Han X,Hu Y,Zhao X,Yin L,Xu L,Qi Y,Xu Y,Han X,Liu K,Peng J

更新日期：2019-01-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used as analgesics. Although the results of clinical studies indicate considerable disparity in the analgesic efficacy of NSAIDs, the pre-clinical models generally used for the study of nociception do not allow a clear distinction to be made between the ana...

journal_title：Pharmacological research

authors： Bianchi M,Panerai AE

更新日期：2002-02-01 00:00:00

abstract：:Stem cell mediated cardiac repair is an exciting and controversial area of cardiovascular research that holds the potential to produce novel, revolutionary therapies for the treatment of heart disease. Extensive investigation to define cell types contributing to cardiac formation, homeostasis and regeneration has prod...

journal_title：Pharmacological research

authors： Gude NA,Sussman MA

更新日期：2018-01-01 00:00:00

abstract：:Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety of cancer cell lines. The objective of this study was to determine the inhibitory effects of gossypol on cell proliferation. Five human carcinoma cell lines were evaluated including endometrial (RL95-2), ovarian (SKOV-3), me...

journal_title：Pharmacological research

authors： Le Blanc M,Russo J,Kudelka AP,Smith JA

更新日期：2002-12-01 00:00:00

abstract：:We compared the protective abilities of Mangifera indica L. stem bark extract (Vimang) 50-250 mgkg(-1), mangiferin 50 mgkg(-1), vitamin C 100 mgkg(-1), vitamin E 100 mgkg(-1)and beta -carotene 50 mgkg(-1)against the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage in serum, liver, brain as well as i...

journal_title：Pharmacological research

authors： Sánchez GM,Re L,Giuliani A,Núñez-Sellés AJ,Davison GP,León-Fernández OS

更新日期：2000-12-01 00:00:00

abstract：:The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied. The results show that EEP and WSD led to decreased levels of blood glucose (FBG), fructosamine (FRU), malonaldehyde (MDA), nitric oxi...

journal_title：Pharmacological research

authors： Fuliang HU,Hepburn HR,Xuan H,Chen M,Daya S,Radloff SE

更新日期：2005-02-01 00:00:00

abstract：:The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-...

journal_title：Pharmacological research

authors： Jeong HJ,Yi JM,Hong SH,Kong JY,Kim KS,Won JH,Cho KH,Shin TY,Kim HS,Kim HM

更新日期：2002-11-01 00:00:00

abstract：:Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspen...

journal_title：Pharmacological research

authors： Ramos-Romero S,Pérez-Cano FJ,Ramiro-Puig E,Franch A,Castell M

更新日期：2012-09-01 00:00:00

abstract：:This study investigated the impact of benzodiazepine receptor agonist, midazolam and antagonist, flumazenil, on the rat frontal cortex slices oxygen consumption (QO(2)), in presence and absence of gamma-aminobutyric acid (GABA). QO(2) was polarographically determined, using the biological oxygen monitor. As it was pre...

journal_title：Pharmacological research

authors： Obradović DI,Savić MM,Andjelković DS,Ugresić ND,Bokonjić DR

更新日期：2003-02-01 00:00:00

abstract：:Using cultured human keratinocytes, the present study investigates the role of nitric oxide (NO) in the mediation of the antiproliferative effects of ultraviolet light A (UVA). UVA treatment of cells (3-21 J cm (-2)) caused a time- and dose-dependent increase in nitrite formation in a micromolar range. This effect was...

journal_title：Pharmacological research

authors： Podhaisky HP,Klapperstück T,Riemschneider S,Wohlrab W

更新日期：2002-03-01 00:00:00

abstract：:Segetoside I is a plant-derived bisdesmosidic saponin from Vaccaria segetalis (Neck) with reported anticancer activities. This development has raised an interest in the therapeutic potential of segetoside I. Here, we report the in vitro and in vivo antitumor activities of segetoside I against some selected cancer cell...

journal_title：Pharmacological research

authors： Firempong CK,Zhang HY,Wang Y,Chen J,Cao X,Deng W,Zhou J,Wang Q,Tong SS,Yu J,Xu X

更新日期：2016-08-01 00:00:00

abstract：:In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study,we introduced the current ...

journal_title：Pharmacological research

authors： Wu W,Tang Z,Chen J,Gao Y

更新日期：2019-10-01 00:00:00

abstract：:Male weanling Wistar rats were fed a 4% cholestyramine diet and used as a model to demonstrate that a reduction in serum low density lipoproteins stimulates de novo cholesterogenesis leading to DNA synthesis and cell proliferation. Feeding this diet resulted in a decrease in serum very low density lipoproteins and low...

journal_title：Pharmacological research

authors： Kazanecki ME,Melhem MF,Spichty KJ,Kelly RH,Rao KN

更新日期：1989-09-01 00:00:00

abstract：:Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the loss of barrier function and an elevated sensitivity to environmental insults. An increased release of the endogenous cannabinoid, anandamide in response to inhalation of allergen in asthmatic patients has been reported. ...

journal_title：Pharmacological research

authors： Shang VC,O'Sullivan SE,Kendall DA,Roberts RE

更新日期：2016-03-01 00:00:00

abstract：:Secretion of matrix metalloproteinases (MMPs) by macrophages and smooth muscle cells (SMC) may impair atherosclerotic cap integrity leading to atherosclerosis complications. Selective estrogen receptor modulators (SERMs) have favourable impact on plasma lipid levels, but their role in the prevention of atherosclerosis...

journal_title：Pharmacological research

authors： Bellosta S,Baetta R,Canavesi M,Comparato C,Granata A,Monetti M,Cairoli F,Eberini I,Puglisi L,Corsini A

更新日期：2007-08-01 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) have been shown to improve cardiovascular (CV) outcomes in the general population as well as in patients with cardiovascular disease (CVD). Statins' beneficial effects have been attributed to both cholesterol-lowering and cholesterol-independent "pleiotropic" properties. By their...

journal_title：Pharmacological research

authors： Kassimatis TI,Goldsmith DJ

更新日期：2014-10-01 00:00:00

abstract：:Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

journal_title：Pharmacological research

authors： Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

更新日期：2017-03-01 00:00:00

abstract：:Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Foll...

journal_title：Pharmacological research

authors： Panini R,Vandelli MA,Forni F,Pradelli JM,Salvioli G

更新日期：1995-03-01 00:00:00

abstract：:Nephrotoxicity associated with cyclosporine A (CsA) administration is characterized by marked renal vasoconstriction, interstitial fibrosis and arteriolar hypertrophy. The molecular mechanisms of CsA nephrotoxicity are not well characterized, but previous studies have demonstrated that angiotensin II (Ang II), the pri...

journal_title：Pharmacological research

authors： Padi SS,Chopra K

更新日期：2002-05-01 00:00:00

abstract：:We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...

journal_title：Pharmacological research

authors： Villa V,Thellung S,Bajetto A,Gatta E,Robello M,Novelli F,Tasso B,Tonelli M,Florio T

更新日期：2016-11-01 00:00:00

abstract：:The polyphenol resveratrol is considered to exert many beneficial actions, such as antioxidant, anti-inflammatory, insulin-sensitizer and anticancer effects. Its benefits in patients with type 2 diabetes mellitus (T2DM) are controversial. Our aims were to determine whether resveratrol supplementation at two different ...

journal_title：Pharmacological research

authors： Bo S,Ponzo V,Ciccone G,Evangelista A,Saba F,Goitre I,Procopio M,Pagano GF,Cassader M,Gambino R

更新日期：2016-09-01 00:00:00

abstract：:Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and medicinal plants. In the last decade, a plethora of studies on the pharmacological activities of lupeol have been conducted and have demonstrated that lupeol possesses an extensive range of pharmacological activities such as antic...

journal_title：Pharmacological research

authors： Liu K,Zhang X,Xie L,Deng M,Chen H,Song J,Long J,Li X,Luo J

更新日期：2020-12-11 00:00:00

abstract：:Gamma-vinyl GABA (vigabatrin; VGB), an irreversible inhibitor of GABA-transaminase, was evaluated for its effect on the contractile responses to PGE(2) or its precursor arachidonic acid (AA) in guinea pig ileum (GPI) and non-pregnant rat uterus. Rationale behind this study was the rise in gamma-aminobutyric acid (GABA...

journal_title：Pharmacological research

authors： Raza M,Al-Shabanah OA

更新日期：2003-06-01 00:00:00

abstract：:The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clon...

journal_title：Pharmacological research

authors： Miranda HF,Pinardi G

更新日期：2004-09-01 00:00:00

abstract：:The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

journal_title：Pharmacological research

authors： Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

更新日期：1991-10-01 00:00:00

abstract：:The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease. Indeed, apelin exerts a positive inotropic effect in humans whilst re...

journal_title：Pharmacological research

authors： Besserer-Offroy É,Bérubé P,Côté J,Murza A,Longpré JM,Dumaine R,Lesur O,Auger-Messier M,Leduc R,Marsault É,Sarret P

更新日期：2018-05-01 00:00:00

abstract：:Perfusion of all mammalian heart muscle except hamster with Ca(2+)-free Tyrode and thereafter reperfusion with normal Tyrode causes irreversible damage, the calcium paradox. Our study aims at deciphering the role of creatine kinase, high energy phosphates and Ca(2+)influx in the genesis of myocardial injury in the rat...

journal_title：Pharmacological research

authors： Ray M,Roy R,Chowdhury PD,Srivastava S,Dubey MP

更新日期：2000-03-01 00:00:00

abstract：:Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

journal_title：Pharmacological research

authors： Csaba G,Kovács P,Pállinger E

更新日期：2003-11-01 00:00:00