Abstract：
:Stem cell mediated cardiac repair is an exciting and controversial area of cardiovascular research that holds the potential to produce novel, revolutionary therapies for the treatment of heart disease. Extensive investigation to define cell types contributing to cardiac formation, homeostasis and regeneration has produced several candidates, including adult cardiac c-Kit+ expressing stem and progenitor cells that have even been employed in a Phase I clinical trial demonstrating safety and feasibility of this therapeutic approach. However, the field of cardiac cell based therapy remains deeply divided due to strong disagreement among researchers and clinicians over which cell types, if any, are the best candidates for these applications. Research models that identify and define specific cardiac cells that effectively contribute to heart repair are urgently needed to resolve this debate. In this review, current c-Kit reporter models are discussed with respect to myocardial c-Kit cell biology and function, and future designs imagined to better represent endogenous myocardial c-Kit expression.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Gude NA,Sussman MAdoi
10.1016/j.phrs.2017.06.007subject
Has Abstractpub_date
2018-01-01 00:00:00pages
110-115eissn
1043-6618issn
1096-1186pii
S1043-6618(17)30356-0journal_volume
127pub_type
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