Abstract：
:Major depressive disorder is a worrying mental health problem and obtaining remission from treatment resistant depression (TRD) remains an important clinical issue. Twenty patients (14 women, 6 men) considered as treatment resistant after the fourth step of a seven-step treatment algorithm to obtain remission in major depression received clomipramine 150 mg/day for 1 month (step 5). In case of failure, two subsequent augmentation strategies with lithium and lithium plus triiodothyronine (T3) were implemented. Median Montgomery-Asberg Depression Rating Scale (MADRS) score at initiation of clomipramine treatment was 29 (range 8-43). Treatment with clomipramine alone allowed five patients to achieve sustained remission (MADRS < or = 8), while three patients were responders (MADRS decrease > or = 50%) and three patients were partial responders (MADRS decrease > 25%). Lithium augmentation in 10 patients led to one additional remission, whereas no additional remission was observed in 6 patients with further T3 augmentation. Tricyclic antidepressants have demonstrated efficacy in TRD. The present study suggests that treatment with clomipramine might allow obtaining remission in some patients who do not fully respond despite multiple interventions.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Gervasoni N,Aubry JM,Gex-Fabry M,Bertschy G,Bondolfi Gdoi
10.1016/j.phrs.2008.11.005subject
Has Abstractpub_date
2009-03-01 00:00:00pages
202-6issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(08)00216-8journal_volume
59pub_type
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
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pub_type： 杂志文章,随机对照试验
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journal_title：Pharmacological research
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更新日期：1998-02-01 00:00:00
