Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors.


UNLABELLED:The purpose of this study was an attempt to extrapolate favorable observations on the effects of magnesium on platelets and haemostasis from animal models to humans. Intravenous magnesium in the treatment of acute myocardial infarction has been tested in several large clinical trials and remains controversial. The mechanism for the cardioprotective properties of magnesium is unknown. Based on experimental studies, several different hypotheses have been advanced to explain the benefits of magnesium including it's effects on platelets and haemostasis. However, few studies have analysed such a relationship in humans. This project was designed to assess the effect of bolus magnesium infusion on ex vivo platelet aggregation and certain haemostatic parameters in healthy volunteers. One gram of magnesium was diluted in 50 ml of D5W and infused over a period of 15 min. The changes of platelet aggregability, plasma antithrombin-III, Protein C, total Protein S, fibronectin, endothelin-1, as well as the metabolites of thromboxane and prostacyclin were determined prior to and immediately after magnesium infusion. RESULTS:Serum magnesium concentration increased from 2.10 +/- 0.08 at baseline to 3.12 +/- 0.13 mg dl-1 (P = 0.0002) post-infusion. Magnesium infusion was associated with a significant elevation in ADP (+19.3%); ristocetin (+13.6%); and collagen-induced platelet aggregation (+14.2%); an increase in plasma antithrombin-III (+10.3%) and thromboxane (+49.4%) when compared to pre-infusion levels. Against this, total Protein S (-20.7%), Protein C (-11.2%) and ET-1 (-26.3%) plasma concentrations were markedly decreased. There were no significant differences in plasma fibronectin and prostacyclin levels. Contrary to expectations, magnesium infusion in human volunteers is associated with platelet activation and mostly small unfavourable changes in certain haemostatic factors. However, the observed changes were small and for the most part remained within the normal physiologic range.


Pharmacol Res


Pharmacological research


Serebruany VL,Herzog WR,Schlossberg ML,Gurbel PA




Has Abstract


1997-07-01 00:00:00














  • PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells.

    abstract::Radiotherapy plays a critical role in the treatment of non-small cell lung cancer (NSCLC). However, radioresistance is a major barrier against increasing the efficiency of radiotherapy for NSCLC. To understand the mechanisms underlying NSCLC radioresistance, we previously focused on the potential involvement of PIM1, ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kim W,Youn H,Kwon T,Kang J,Kim E,Son B,Yang HJ,Jung Y,Youn B

    更新日期:2013-04-01 00:00:00

  • Effects of curcumin on HDL functionality.

    abstract::Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subseque...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ganjali S,Blesso CN,Banach M,Pirro M,Majeed M,Sahebkar A

    更新日期:2017-05-01 00:00:00

  • Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats.

    abstract::Lipid peroxidation increased both in the liver homogenates and in the hepatic mitochondrial fraction of bile duct ligated (BDL)-rats. Although mitochondrial superoxide dismutase (SOD) activity did not change in the liver, glutathione (GSH) levels and glutathione peroxidase (GSH-Px) activity decreased in hepatic mitoch...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Alptekin N,Mehmetçik G,Uysal M,Aykaç-toker G

    更新日期:1997-09-01 00:00:00

  • Effect of vaporized ethanol on [1-14C]pyruvate kinetics in mice using a four-compartment closed model.

    abstract::The effect of the inhalation of vaporized ethanol on injected [1-14C]pyruvate kinetics was studied in mice. The [1-14C]pyruvate kinetics were modelled by means of a four-compartment closed model, i.e. injected site, blood, periphery and expired 14CO2. The results show that the inhalation of vaporized ethanol can stimu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Wu G

    更新日期:1998-01-01 00:00:00

  • Effects of clonidine on the experimental hypertension by abdominal aortic coarctation in rats.

    abstract::Cardiovascular baroreflex mechanisms and sympathetic tone could be involved in the arterial hypertension by coarctation of abdominal aorta artery (CoA). The present work analyzes the effect on the arterial pressure and heart rate (HR) of the clonidine, an alpha(2)-adrenergic central acting antihypertensive agent, afte...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gorzalczany SB,Opezzo JA,del Carmen Garcia M,Taira CA

    更新日期:2003-07-01 00:00:00

  • Novel indole-based compounds that differentiate alkylindole-sensitive receptors from cannabinoid receptors and microtubules: Characterization of their activity on glioma cell migration.

    abstract::Indole-based compounds, such as the alkyl-indole (AI) compound WIN55212-2, activate the cannabinoid receptors, CB1 and CB2, two well-characterized G protein-coupled receptors (GPCR). Reports indicate that several indole-based cannabinoid agonists, including WIN55212-2, lack selectivity and interact with at least two a...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Fung S,Xu C,Hamel E,Wager-Miller JB,Woodruff G,Miller A,Sanford C,Mackie K,Stella N

    更新日期:2017-01-01 00:00:00

  • Therapeutic effects of I(f) blockade: evidence and perspective.

    abstract::Heart rate slowing has been accepted for decades as a primary therapeutic approach to prevention (and even to treatment) of angina pectoris. Pure heart rate slowing has not been achieved with previously available rate-slowing pharmacological agents (beta adrenergic blockers, certain calcium channel blockers), all of w...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Borer JS

    更新日期:2006-05-01 00:00:00

  • The distribution of catecholamines between plasma and platelets in cyclosporin A-induced hypertensive rats.

    abstract::One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Reis F,Tavares P,Teixeira F

    更新日期:2000-02-01 00:00:00

  • Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials.

    abstract::The effects of Nigella sativa (NS) on plasma lipid concentrations are controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to obtain a conclusive result in humans. PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (up to August 2015)...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sahebkar A,Beccuti G,Simental-Mendía LE,Nobili V,Bo S

    更新日期:2016-04-01 00:00:00

  • Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.

    abstract::DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

    更新日期:2010-02-01 00:00:00

  • Poly(ADP-ribosyl)ation and stroke.

    abstract::Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Chiarugi A

    更新日期:2005-07-01 00:00:00

  • Weight control and prevention of metabolic syndrome by green tea.

    abstract::Green tea (Camellia sinensis, Theaceace) is the second most popular beverage in the world and has been extensively studied for its putative disease preventive effects. Green tea is characterized by the presence of a high concentrations of polyphenolic compounds known as catechins, with (-)-epigallocatechin-3-gallate (...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sae-tan S,Grove KA,Lambert JD

    更新日期:2011-08-01 00:00:00

  • Pyridoxol L,2-pyrrolidon-5 carboxylate prevents active fibroplasia in CCl4-treated rats.

    abstract::In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

    更新日期:1992-01-01 00:00:00

  • The influence of midazolam and flumazenil on rat brain slices oxygen consumption.

    abstract::This study investigated the impact of benzodiazepine receptor agonist, midazolam and antagonist, flumazenil, on the rat frontal cortex slices oxygen consumption (QO(2)), in presence and absence of gamma-aminobutyric acid (GABA). QO(2) was polarographically determined, using the biological oxygen monitor. As it was pre...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Obradović DI,Savić MM,Andjelković DS,Ugresić ND,Bokonjić DR

    更新日期:2003-02-01 00:00:00

  • Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety.

    abstract::Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

    更新日期:2017-08-01 00:00:00

  • A review of gene- and cell-based therapies for familial hypercholesterolemia.

    abstract::Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Hajighasemi S,Mahdavi Gorabi A,Bianconi V,Pirro M,Banach M,Ahmadi Tafti H,Reiner Ž,Sahebkar A

    更新日期:2019-05-01 00:00:00

  • New perspectives in melatonin uses.

    abstract::This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potent...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Carpentieri A,Díaz de Barboza G,Areco V,Peralta López M,Tolosa de Talamoni N

    更新日期:2012-04-01 00:00:00

  • Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice.

    abstract::Our goal was to establish the requirement of β3 adrenoceptor (β3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and β3Adr knockout (KO) male mice fed with a standard diet or a high-fat diet (HFD/16 weeks) treated or not with GT (0.5 g/kg of body weig...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sousa-Filho CPB,Faria HOF,Esposito JC,Melo A,Ribeiro MO,Otton R

    更新日期:2020-09-01 00:00:00

  • Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition.

    abstract::Excess fructose consumption causes high prevalence of metabolic syndrome and inflammatory liver diseases. The aim of the current study was to investigate the therapeutic effects and underlying molecular mechanisms of curcumin and allopurinol in high fructose-induced hepatic inflammation. Male Sprague-Dawley rats were ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ding XQ,Wu WY,Jiao RQ,Gu TT,Xu Q,Pan Y,Kong LD

    更新日期:2018-11-01 00:00:00

  • Insulinotropic action of novel succinic acid esters.

    abstract::The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succini...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Björkling F,Malaisse-Lagae F,Malaisse WJ

    更新日期:1996-04-01 00:00:00

  • Newer agents for coronary thrombolysis. Perspectives from clinical studies.

    abstract::Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

    更新日期:1989-03-01 00:00:00

  • Muscarinic M(2) receptors are not primarily involved in the contraction of guinea-pig gallbladder smooth muscle.

    abstract::The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

    更新日期:1999-11-01 00:00:00

  • Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors.

    abstract::The mechanism for the pathological increase in cell death in various disease states e.g. HIV immunodefficiency or even ageing or Alzheimer's disease, occurs by complex and as yet undefined mechanism(s) related to immunological, virological or biochemical disturbances (i.e. energy depletion, oxidative stress, increased...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Virmani MA,Biselli R,Spadoni A,Rossi S,Corsico N,Calvani M,Fattorossi A,De Simone C,Arrigoni-Martelli E

    更新日期:1995-12-01 00:00:00

  • Modification of reserpine-induced emetic response in pigeons by alpha 2-adrenoceptors.

    abstract::In the present study, an attempt has been made to elucidate the role of alpha 2-adrenoceptors in reserpine-induced emesis in pigeons. Reserpine was found to induce dose-dependent emesis and a 500 micrograms kg-1 dose was found to be the 100% emetic dose. alpha 2-adrenoceptor agonists clonidine and alpha-methylnoradren...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Khandker SK,Mukerjee D,Gurtu S,Pant KK,Dhawan KN,Sinha JN

    更新日期:1994-05-01 00:00:00

  • Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.

    abstract::Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as t...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zheng P,Wang Q,Teng J,Chen J

    更新日期:2015-09-01 00:00:00

  • A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19).

    abstract::The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization (WHO), and its harm degree is defined as a global "pandemic". At present, the efforts of various countries focus on the rapid di...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Huang F,Li Y,Leung EL,Liu X,Liu K,Wang Q,Lan Y,Li X,Yu H,Cui L,Luo H,Luo L

    更新日期:2020-08-01 00:00:00

  • Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.

    abstract::Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 recepto...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lethbridge NL,Chazot PL

    更新日期:2016-11-01 00:00:00

  • Niclosamide ethanolamine inhibits artery constriction.

    abstract::We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) is a salt form of niclosamide and has ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Li SL,Yan J,Zhang YQ,Zhen CL,Liu MY,Jin J,Gao JL,Xiao XL,Shen X,Tai Y,Hu N,Zhang XZ,Sun ZJ,Dong DL

    更新日期:2017-01-01 00:00:00

  • Resveratrol plus ethanol counteract the ethanol-induced impairment of energy metabolism: ³¹P NMR study of ATP and sn-glycerol-3-phosphate on isolated and perfused rat liver.

    abstract::The effects of trans-resveratrol (RSV) combined with ethanol (EtOH) were evaluated by (31)P NMR on total ATP and sn-glycerol-3-phosphate (sn-G3P) contents measured in real time in isolated and perfused whole liver of the rat. Mitochondrial ATP turnover was assessed by using specific inhibitors of glycolytic and mitoch...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gallis JL,Serhan N,Gin H,Couzigou P,Beauvieux MC

    更新日期:2012-03-01 00:00:00

  • Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.

    abstract::Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

    更新日期:2005-06-01 00:00:00