Antimalarial efficacy of arteether against multiple drug resistant strain of Plasmodium yoelii nigeriensis.

Abstract:

:New quick-acting blood schizontocides are needed to contain the spread of multiple drug resistant strains of P. falciparum and for the treatment of the cerebral malaria cases. A multiple drug resistant strain of P. yoelii nigeriensis resistant to mefloquine (128 mg/kg x 6 days), quinine (300 mg/kg x 7 days) and chloroquine (64 mg/kg x 8 days) was found to be completely susceptible to arteether (a 30:70 mixture of alpha and beta enantiomers) and a dose of 5 mg/kg x 3 days by i.m. route was curative in Swiss mice. Artemisinin at 50 mg/kg x 7 days had only suppressive action against this strain.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Dutta GP,Bajpai R,Vishwakarma RA

doi

10.1016/1043-6618(89)90159-x

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

415-9

issue

4

eissn

1043-6618

issn

1096-1186

journal_volume

21

pub_type

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