Abstract:
:Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario suggests the provocative hypothesis that pharmacological modulation of clock-related proteins may be suitable as an effective anticancer strategy. In this review, we focus on the functions of the druggable circadian nuclear receptors, REV-ERBα and REV-ERBβ, in cancer cell survival and describe the potential development of small molecule compounds that modulate REV-ERB activity as novel anticancer therapeutics. In addition, we debate the use of circadian rhythm-based synthetic lethal approaches to identify yet unexplored anticancer strategies.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi Bdoi
10.1016/j.phrs.2015.08.008subject
Has Abstractpub_date
2015-10-01 00:00:00pages
288-95eissn
1043-6618issn
1096-1186pii
S1043-6618(15)00176-0journal_volume
100pub_type
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