Abstract：
:Treatment of pediatric diabetes can be challenging. Strict glucose control can be accompanied by hypoglycemia and weight gain. Recently, there have been many developments in insulin preparations and delivery methods which make insulin levels more close to a physiologic pattern. Newly developed rapid/long acting analogues and delivery devices such as continuous subcutaneous insulin infusion (CSII, insulin pump) may reduce hypoglycemia and improve glycemic control. CSII combined with continuous glucose monitoring can achieve even better glycemic control. The closed-loop system is rapidly evolving and an artificial pancreas will be available in the near future. It is now recognized that several hormones other than insulin such as glucagon, amylin, and incretins contribute to glucose homeostasis. The role of co-adjuncts such as metformin, amylin analogues, and incretin based therapy is now emerging. Immunotherapy in a high risk population or patients in the early phase of type 1 diabetes may prevent further destruction of pancreatic β cells.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Kim J,Kim SM,Nguyen HC,Redondo MJdoi
10.1016/j.phrs.2011.08.011subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1-4issue
1eissn
1043-6618issn
1096-1186pii
S1043-6618(11)00254-4journal_volume
65pub_type
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