Reduce, Induce, Thrive: Bacterial Redox Sensing during Pathogenesis.

Abstract:

:The abundance of oxidants and reductants must be balanced for an organism to thrive. Bacteria have evolved methods to prevent redox imbalances and to mitigate their deleterious consequences through the expression of detoxification enzymes, antioxidants, and systems to repair or degrade damaged proteins and DNA. Regulating these processes in response to redox changes requires sophisticated surveillance strategies ranging from metal chelation to direct sensing of toxic reactive oxygen species. In the case of bacterial pathogens, stress that threatens to disrupt redox homeostasis can derive from endogenous sources (produced by the bacteria) or exogenous sources (produced by the host). This minireview summarizes the sources of redox stress encountered during infection, the mechanisms by which bacterial pathogens diminish the damaging effects of redox stress, and the clever ways some organisms have evolved to thrive in the face of redox challenges during infection.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Reniere ML

doi

10.1128/JB.00128-18

subject

Has Abstract

pub_date

2018-08-10 00:00:00

issue

17

eissn

0021-9193

issn

1098-5530

pii

JB.00128-18

journal_volume

200

pub_type

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