Abstract:
:Deficits in inhibitory control and visual processing are common in youths with attention-deficit/hyperactivity disorder (ADHD), but little is known about endophenotypes for unaffected siblings of youths with ADHD. This study aimed to investigate the potential endophenotypes of brain activation and performance in inhibitory control and visual processing among ADHD probands, their unaffected siblings, and neurotypical youths. We assessed 27 ADHD probands, 27 unaffected siblings, and 27 age-, gender-, and IQ-matched neurotypical youths using the counting Stroop functional magnetic resonance imaging and two tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB): rapid visual information processing (RVP) for inhibitory control and spatial span (SSP) for visual processing. ADHD probands showed greater activation than their unaffected siblings and neurotypical youths in the right inferior frontal gyrus (IFG) and anterior cingulate cortex. Increased activation in the right IFG was positively correlated with the mean latency of the RVP in ADHD probands. Moreover, ADHD probands and their unaffected siblings showed less activation in the left superior parietal lobule (SPL) than neurotypical youths. Increased activation in the left SPL was positively correlated with the spatial length of the SSP in neurotypical youths. Our findings suggest that less activation in the left SPL might be considered as a candidate imaging endophenotype for visual processing in ADHD.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Fan LY,Shang CY,Tseng WI,Gau SS,Chou TLdoi
10.1002/hbm.24214subject
Has Abstractpub_date
2018-10-01 00:00:00pages
3827-3835issue
10eissn
1065-9471issn
1097-0193journal_volume
39pub_type
杂志文章abstract::Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by compariso...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23846
更新日期:2018-01-01 00:00:00
abstract:UNLABELLED:Major depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or repre...
journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24274
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abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...
journal_title:Human brain mapping
pub_type: 杂志文章
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abstract::Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) was performed on 54 children (age 10.1 ± 1.0 years) from the Cape Town Longitudinal Cohort, for whom detailed drinking histories obtain...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23218
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20811
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20468
更新日期:2008-12-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.20602
更新日期:2008-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23887
更新日期:2018-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22852
更新日期:2015-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23717
更新日期:2017-10-01 00:00:00
abstract::Gait disturbances, including freezing of gait, are frequent and disabling symptoms of Parkinson's disease. They often respond poorly to dopaminergic treatments. Although recent studies have shed some light on their neural correlates, their modulation by dopaminergic treatment remains quite unknown. Specifically, the i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22679
更新日期:2015-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21396
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:Brisk walking, a sensitive test to evaluate gait capacity in normal and pathological aging such as parkinsonism, is used as an alternative to classical fitness program for motor rehabilitation and may help to decrease the risk of cognitive deterioration observed with aging. In this study, we aimed to identif...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21255
更新日期:2012-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20605
更新日期:2009-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23467
更新日期:2017-03-01 00:00:00
abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24039
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emissi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20344
更新日期:2007-12-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10079
更新日期:2003-02-01 00:00:00
abstract::Anxiety arising during pain expectancy can modulate the subjective experience of pain. However, individuals differ in their sensitivity to pain expectancy. The amygdale and hippocampus were proposed to mediate the behavioral response to aversive stimuli. However, their differential role in mediating anxiety-related in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20867
更新日期:2010-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25090
更新日期:2020-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24533
更新日期:2019-06-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24604
更新日期:2019-08-01 00:00:00
abstract::Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0
更新日期:1996-01-01 00:00:00
abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20884
更新日期:2010-04-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23359
更新日期:2017-01-01 00:00:00
abstract::Recently, it has been suggested that backwardly masked, and thus subliminally presented, fearful eyes are processed by the amygdala. Here, we investigated in four functional magnetic resonance imaging experiments whether the amygdala responds to subliminally presented fearful eyes per se or whether an interaction of m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20960
更新日期:2010-10-01 00:00:00
abstract::Prenatal alcohol exposure (PAE) can cause central nervous system dysfunction and widespread structural anomalies as detected by magnetic resonance imaging (MRI). This study focused on diffusion tensor imaging (DTI) of white matter in a large sample of PAE participants that allowed us to examine correlations with behav...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23371
更新日期:2017-01-01 00:00:00