Abstract：
:Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected men and women observed for 12 years and left free to intake food or beverages containing caffeine was studied. Subjects were stratified into tertiles of caffeine intake both in the whole cohort and after genotyping for the -163C > A polymorphism of the CYP1A2 gene, regulating caffeine metabolism. Results In the whole cohort, the 12-year incidence of atrial fibrillation was significantly lower in the third (2.2%) than in the first (10.2%) or second (5.7%) tertile of caffeine intake ( P < 0.001). The same trend was observed in all genotypes; the apparently steeper reduction of atrial fibrillation in slow caffeine metabolisers found at univariate analysis was proved wrong by multivariate Cox analysis. Age, chronic pulmonary disease, history of heart failure and of coronary artery disease, and systolic blood pressure - but not the genotype or the caffeine × CYP1A2 interaction term - were significant confounders of the association between incident atrial fibrillation and being in the third tertile of caffeine intake (hazard ratio 0.249, 95% confidence intervals 0.161-0.458, P < 0.01). Conclusions A higher caffeine intake (>165 mmol/day or > 320 mg/day) is associated with a lower incidence of atrial fibrillation in the 12-year epidemiological prospective setting based on the general population.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Casiglia E,Tikhonoff V,Albertini F,Gasparotti F,Mazza A,Montagnana M,Danese E,Benati M,Spinella P,Palatini Pdoi
10.1177/2047487318772945subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1055-1062issue
10eissn
2047-4873issn
2047-4881journal_volume
25pub_type
杂志文章abstract：BACKGROUND:The complexity of treatment regimens, costs and pill burden decrease the medication adherence and contribute to shortfall in cardiovascular preventive drug coverage. The polypill, a fixed dose combination pill of established drugs, is expected to increase adherence and reduce the costs whilst preventing majo...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/2047487314550803
更新日期：2015-12-01 00:00:00
abstract：:Despite improvements in pharmacotherapy, morbidity and mortality rates in community-based populations with chronic heart failure still remain high. The increase in medical complexity among patients with heart failure may be reflected by an increase in concomitant non-cardiovascular comorbidities, which are recognized ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487320957793
更新日期：2020-12-01 00:00:00
abstract：AIMS:Exercise is recommended as prevention, management, and control of all stages of hypertension. There are still controversies about the optimal training dose, frequency, and intensity. We aimed to study the effect of aerobic interval training on blood pressure and myocardial function in hypertensive patients. METHO...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/1741826711400512
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487314560663
更新日期：2015-12-01 00:00:00
abstract：:Patients with coeliac disease and myocardial infarction have a more favourable atherosclerotic risk factor profile than controls with myocardial infarction (MI). Therefore, MI prognosis and treatment may differ according to coeliac status. This paper reports on the study of Swedish MI patients with and without coeliac...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313502446
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in h...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487314552797
更新日期：2015-09-01 00:00:00
abstract：:Background The ratio of estimated glomerular filtration rate (eGFR) to kidney size reflects the kidney's capacity for filtration per kidney volume or kidney length. High ratios of eGFR to kidney size, which might indicate glomerular hyperfiltration, could be related to kidney function decline, cardiovascular disease a...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317690950
更新日期：2017-06-01 00:00:00
abstract：:Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and app...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487316663873
更新日期：2016-12-01 00:00:00
abstract：:Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in appa...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/2047487317703826
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Extracellular vesicles are released upon cellular activation and mediate inter-cellular communication. Individual species of extracellular vesicles might have divergent roles in vascular homeostasis and may show different responses to therapies such as exercise training. AIMS:We examine endothelial effects ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320919894
更新日期：2020-05-07 00:00:00
abstract：AIMS:Self-monitoring and self-titration of antihypertensives (self-management) is a novel intervention which improves blood pressure control. However, little evidence exists regarding the cost-effectiveness of self-monitoring of blood pressure in general and self-management in particular. This study aimed to evaluate w...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/2047487313501886
更新日期：2014-12-01 00:00:00
abstract：:Background Statin treatment in association with physical exercise can substantially reduce mortality in dyslipidaemic individuals. However, the available data to compare the efficacy and safety of statins and exercise combination therapy with statin monotherapy are limited. Design Systematic review and meta-analysis. ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487317691874
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to test the hypothesis that alcohol consumption, both observational (self-reported) and estimated by genetic instruments, is associated with a risk of atrial fibrillation and to determine whether people with high cardiovascular risk are more sensitive towards alcohol than people wit...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/2047487316641804
更新日期：2016-09-01 00:00:00
abstract：:Background Smartphone manufacturers offer mobile health monitoring technology to their customers, including apps using the built-in camera for heart rate assessment. This study aimed to test the diagnostic accuracy of such heart rate measuring apps in clinical practice. Methods The feasibility and accuracy of measurin...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/2047487317702044
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown. OBJECTIVE:The purpose of this study was to investigate the prevalence of abdominal obesity and its association with recurrent atherosclerotic cardiovascular disease in ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319898019
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:The test-retest reliability for multiple cardiopulmonary exercise test (CPX) variables has not been compared in a single study and the influence of different diseases on test-retest reliability has not been examined. We investigated different measures of test-retest reliability for multiple variables and com...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313518474
更新日期：2014-04-01 00:00:00
abstract：:Background Epidemiological studies on smoking and atrial fibrillation have been inconsistent, with some studies showing a positive association while others have found no association. It is also unclear whether there is a dose-response relationship between the number of cigarettes smoked or pack-years and the risk of a...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析
doi：10.1177/2047487318780435
更新日期：2018-09-01 00:00:00
abstract：:Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposi...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487319848105
更新日期：2020-05-01 00:00:00
abstract：:Background This study examined the association between cardiac structure and function and the deterioration in activities of daily living (ADLs) in an age-homogenous, community-dwelling population of patients born in 1920-1921 over a five-year follow-up period. Design Longitudinal cohort study. Methods Patients were r...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317744365
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/2047487312460520
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:While cardiorespiratory fitness is strongly related to survival, there are limited data regarding musculoskeletal fitness indicators. Our aim was to evaluate the association between the ability to sit and rise from the floor and all-cause mortality. DESIGN:Retrospective cohort. METHODS:2002 adults aged 51-...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487312471759
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:This study aimed to examine the mediating role of psychological distress in the relationship between the physical health component of health-related quality of life (HRQoL) of coronary heart disease patients and their socio-demographic and clinical characteristics. METHODS:This was a cross-sectional study c...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/2047487312451541
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:There is strong evidence to suggest that social deprivation is linked to health inequalities. In the UK, concerns have been raised regarding disparities in the outcomes of acute cardiac services within the National Health Service (NHS). This study explored whether differences exist in (a) elective hospital p...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487314567000
更新日期：2016-02-01 00:00:00
abstract：:Numerous molecular screening strategies have recently been developed to measure the chemical diversity of a population's biofluids with the ultimate aim to provide clinicians, medical scientists and epidemiologists with a clearer picture of the presence and severity of cardiovascular disease; prognosis; and response t...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487316645469
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:As with ischaemic heart disease, cardiac rehabilitation (CR) is recommended for patients undergoing heart valve surgery; recommendations are based on limited evidence. The organization of CR programmes and factors associated with uptake among patients undergoing heart valve surgery have not been studied. Thi...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487314536364
更新日期：2015-06-01 00:00:00
abstract：:Background Preliminary evidence suggests that peak exercise oxygen pulse - peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden car...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487318761679
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Trials of weight-loss drugs indicate some benefits on lipids, blood glucose, or blood pressure levels. Since obesity is associated with increased cardiovascular (CV) medication use and pharmaceutical costs, weight-loss drug use could beneficially impact CV medication use. OBJECTIVE:We examined the temporal ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711406058
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Urban middle-socioeconomic status (SES) subjects have high burden of cardiovascular risk factors in low-income countries. To determine secular trends in risk factors among this population and to correlate risks with educational status we performed epidemiological studies in India. METHODS:Five cross-section...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711424567
更新日期：2012-12-01 00:00:00
abstract：:The United States Food and Drug Administration (FDA) has introduced manufacturing standards for dietary supplements, including red yeast rice, to assure their identity, purity, strength, and composition. One supplement commonly used to self-treat high cholesterol, red yeast rice, may contain monacolin K, an ingredient...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317715714
更新日期：2017-09-01 00:00:00
abstract：:Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317743355
更新日期：2018-02-01 00:00:00
