Abstract:
:Numerous molecular screening strategies have recently been developed to measure the chemical diversity of a population's biofluids with the ultimate aim to provide clinicians, medical scientists and epidemiologists with a clearer picture of the presence and severity of cardiovascular disease; prognosis; and response to treatment. Current cardiology practice integrates clinical history and examination with state-of-the-art imaging, invasive measures, and electrical interrogation. Biomarkers in common clinical use are relatively limited to troponin and brain natriuretic peptide, dependent on damage to heart muscle, or myocyte 'stretch' respectively. Although they have been recently applied to risk stratification in asymptomatic individuals at higher risk, the development of markers capable of detecting earlier phases of disease development would facilitate targeted strategies to prevent pathological complications in the general community. Metabolomics is the systematic study of small molecules in biological fluids. Profiling strategies aim to comprehensively measure and quantify such biomarkers in a fast, cost-effective and clinically informative manner. Techniques tend to be applied in an unbiased fashion, with advanced statistical methods allowing for identification of signature profiles in particular cohorts. In this manner, metabolomics has the potential to identify new pathophysiological pathways, and thus therapeutic targets, as well as assist in improved risk-stratification and personalized cardiovascular medicine. The latter has great potential in the primary and secondary cardiovascular disease prevention settings, integrating known and as yet unidentified host and environmental factors. The current review discusses applications of metabolomic techniques relevant to both the research and the clinical cardiologist.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Dona AC,Coffey S,Figtree Gdoi
10.1177/2047487316645469subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1578-89issue
15eissn
2047-4873issn
2047-4881pii
2047487316645469journal_volume
23pub_type
杂志文章,评审abstract::Patients with type 2 diabetes mellitus suffer from dysregulation of a plethora of cardiovascular and metabolic functions, including dysglycaemia, dyslipidaemia, arterial hypertension, obesity and a reduced cardiorespiratory fitness. Exercise training has the potential to improve many of these functions, such as insuli...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,实务指引
doi:10.1177/2047487318820420
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Evaluation of health-related quality of life (HRQL) is important in improving the quality of patient care. The aim of this study was to determine the psychometric properties of the HeartQoL in patients with ischemic heart disease (IHD), specifically angina, myocardial infarction (MI), or ischemic heart failu...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487312450545
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The role of extended thromboprophylaxis is established for surgical patients, but not yet for hospitalised medical patients. DESIGN:This systematic review and meta-analysis sought to explore the role of extended thromboprophylaxis for medically ill hospitalised patients. METHODS:Medline, EMBASE and Cochran...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319836572
更新日期:2019-03-16 00:00:00
abstract::Background Patient activity (PA) has been demonstrated to predict all-cause mortality. However, the association between PA and cardiac death is unclear. Aims The aims of this study were to determine whether PA can predict cardiac death and what is the cut-off of PA to discriminate cardiac death, as well as the mechani...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316688982
更新日期:2017-05-01 00:00:00
abstract:AIMS:Recent European guidelines recommend in patients with atherosclerotic cardiovascular disease to achieve a reduction of low-density lipoprotein-cholesterol of at least 50% if the baseline low-density lipoprotein-cholesterol level is between 1.8 and 3.5 mmol/L. Systematic reviews have associated a given statin/dose ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319874898
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to test the hypothesis that alcohol consumption, both observational (self-reported) and estimated by genetic instruments, is associated with a risk of atrial fibrillation and to determine whether people with high cardiovascular risk are more sensitive towards alcohol than people wit...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316641804
更新日期:2016-09-01 00:00:00
abstract:AIMS:To investigate whether levels of thyroid-stimulating hormone (TSH) within the normal range are associated with an increased risk of new vascular events and mortality in patients with clinical manifest vascular diseases and whether this relation is influenced by adiposity. METHODS AND RESULTS:Prospective cohort st...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711416045
更新日期:2012-08-01 00:00:00
abstract::Background Smartphone manufacturers offer mobile health monitoring technology to their customers, including apps using the built-in camera for heart rate assessment. This study aimed to test the diagnostic accuracy of such heart rate measuring apps in clinical practice. Methods The feasibility and accuracy of measurin...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/2047487317702044
更新日期:2017-08-01 00:00:00
abstract::The clinical benefits of rehabilitation in cardiovascular disease are well established. Among cardiovascular disease patients, however, patients with type 2 diabetes mellitus require a distinct approach. Specific challenges to clinicians and healthcare professionals in patients with type 2 diabetes include the prevale...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487319882820
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND AIM:We aimed to investigate cardiovascular risk factors and health behaviours prospectively in a large population of French amateur rugby players. METHODS:An anonymous questionnaire was displayed to rugby players aged over 12 years enrolled in the 2014-2015 French amateur rugby championship from the Bur...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319837066
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the validity and reliability of the HeartQoL instrument in a population of stable coronary patients. DESIGN:Analyses are based on the cross-sectional EUROASPIRE IV (EUROpean Action on Secondary and Primary prevention through Intervention to Reduce Events) survey. ME...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315604837
更新日期:2016-05-01 00:00:00
abstract::Background Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316679904
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315626547
更新日期:2016-08-01 00:00:00
abstract::Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity also translates into cardiovascular health benefits in older adults. Therefore, we aimed to c...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317737628
更新日期:2018-01-01 00:00:00
abstract::Background Cardiac rehabilitation (CR) improves the symptoms, exercise capacity and quality of life of chronic heart failure (CHF) patients. Its effects on new plasma biomarkers of prognostic importance are unknown. The present study aimed at analysing the effects of a structured CR programme on plasma cardiac biomark...
journal_title:European journal of preventive cardiology
pub_type: 临床试验,杂志文章
doi:10.1177/2047487317705488
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:While there is evidence of poor health behaviours in anxious and depressed cardiac patients, it is possible that sociodemographic factors explain these associations. Few previous studies have adequately controlled for confounders. The present study investigated health behaviours in anxious and depressed ca...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487312449593
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:There is strong evidence to suggest that social deprivation is linked to health inequalities. In the UK, concerns have been raised regarding disparities in the outcomes of acute cardiac services within the National Health Service (NHS). This study explored whether differences exist in (a) elective hospital p...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314567000
更新日期:2016-02-01 00:00:00
abstract:AIMS:To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS:PLATO (n = 18,624) was a multicentre, double-blind, randomized trial in ACS, that showed a 16% reduction in cardiovascular death (CV-death), myocar...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314533215
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487314560663
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Urban middle-socioeconomic status (SES) subjects have high burden of cardiovascular risk factors in low-income countries. To determine secular trends in risk factors among this population and to correlate risks with educational status we performed epidemiological studies in India. METHODS:Five cross-section...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711424567
更新日期:2012-12-01 00:00:00
abstract::Background Preliminary evidence suggests that peak exercise oxygen pulse - peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden car...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318761679
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Population-based risk factor combinations and residual risks for coronary heart disease (CHD) patients on statins were assessed in order to bridge the gap between knowledge on relative effects from clinical trials and absolute risk from real-world practice. DESIGN:Population-based, retrospective 1-year cros...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826710392668
更新日期:2012-02-01 00:00:00
abstract:AIMS:Exposure to airborne particulate matter has been consistently associated with early death and increased morbidity, particularly raising the risk of cardiovascular disease. Obesity, one of the leading cardiovascular disease risk factors, increases susceptibility to the adverse effects of particulate matter exposure...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318815320
更新日期:2019-04-01 00:00:00
abstract::Exercise-induced ischemic preconditioning (IPC) can be assessed with the second exercise stress test during sequential testing. Exercise-induced IPC is defined as the time to 1 mm ST segment depression (STD), the rate-pressure product (RPP) at 1 mm STD, the maximal ST depression and the rate-pressure product at peak e...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487313502447
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Exercise oscillatory ventilation is an ominous outcome sign in heart failure due to reduced left ventricular ejection fraction; currently, the prevalence of exercise oscillatory ventilation is unknown in left ventricular assist device recipients. METHODS:We studied cardiopulmonary exercise testing in heart ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318801415
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The effects of increasing high-density lipoprotein cholesterol on cardiovascular outcomes remain uncertain. DESIGN:We conducted a meta-analysis to investigate the effects of high-density lipoprotein cholesterol modifiers (niacin, fibrates and cholesteryl ester transfer protein inhibitors) on cardiovascular ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487318816495
更新日期:2019-03-01 00:00:00
abstract::Aims To explore the predictive and explanatory factors on the incidence of cardiovascular disease and the impact of visit-to-visit variability (VVV) of risk factors on incident cardiovascular disease in people with type 2 diabetes with no history of prior cardiovascular disease. Methods We performed a historical cohor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317707293
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To determine the cost-effectiveness of apixaban versus warfarin in patients with atrial fibrillation (AF) with a moderate to severe risk of stroke, from an Australian government-perspective. METHODS:A decision-analytic Markov model was constructed to assess the cost-effectiveness of apixaban versus warfarin,...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313514019
更新日期:2015-03-01 00:00:00
abstract:AIMS:Due to improving cancer treatment results, non-cancer mortality is an important issue for cancer survivors. Cardiovascular diseases are the leading causes of death in Korea and globally. In addition to lowering the risk of cardiovascular disease, the use of statins has led to an overall reduction in cancer mortali...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320905722
更新日期:2020-02-23 00:00:00
abstract:BACKGROUND:The exercise electrocardiographic stress test (ExET) is the most widely used non-invasive diagnostic method to detect coronary artery disease. However, the sole ST depression criteria (ST-max) have poor specificity for coronary artery disease in patients with left ventricular hypertrophy. We hypothesised tha...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316655259
更新日期:2016-10-01 00:00:00